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1. Full Text Focus Theme Issue: "Vitiligo and other pigmentary disorders"
by Picardo, M and Taieb, A
EXPERIMENTAL DERMATOLOGY, ISSN 0906-6705, 06/2019, Volume 28, Issue 6, pp. 639 - 641
MELANOGENESIS | DERMATOLOGY
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2. Full Text The Organogermanium Compound THGP Suppresses Melanin Synthesis via Complex Formation with L-DOPA on Mushroom Tyrosinase and in B16 4A5 Melanoma Cells
by Azumi, Junya and Takeda, Tomoya and Shimada, Yasuhiro and Aso, Hisashi and Nakamura, Takashi
International Journal of Molecular Sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 19, p. 4785
The organogermanium compound 3-(trihydroxygermyl)propanoic acid (THGP) has various biological activities. We previously reported that THGP forms a complex with... 
melanogenesis | organogermanium | THGP
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3. Full Text Resveratrol as a k cat type inhibitor for tyrosinase: Potentiated melanogenesis inhibitor
by Satooka, Hiroki and Kubo, Isao
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 01/2012, Volume 20, Issue 2, pp. 1090 - 1099
Resveratrol exhibited the inhibitory activity against mushroom tyrosinase (EC1.14.18.1) through a k inhibition. Resveratrol itself did not inhibit tyrosinase... 
Resveratrol | Inhibitor | Melanogenesis | Tyrosinase
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4. Full Text Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo
by Ki Wung Chunga and Hyeong Oh Jeonga and Eun Kyeong Leea and Su Jeong Kima and Pusoon Chunb and Hae Young Chunga and Hyung Ryong Moona and aCollege of Pharmacy and Inje University and bCollege of Pharmacy and Pusan National University
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 1, pp. 73 - 79
Abnormal pigmentation owing to excessive melanin synthesis can result in serious problems such as freckles, age-spots, and melanoma. Tyrosinase inhibitors have... 
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5. Full Text Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase
by Jeong Ah Hwang and Nok Hyun Park and Yong Joo Na and Hae Kwang Lee and John Hwan Lee and Yong Jin Kim and Chang Seok Lee and Amorepacific R&D Corporation Center
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 4, pp. 535 - 539
Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark... 
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6. Full Text (Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene) thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors
by Kyeong Ha Kanga and Bonggi Leea and Sujin Sona and b and Hwi Young Yuna and Kyoung Mi Moona and Hyoung Oh Jeonga and Dae Hyun Kima and Eun Kyeong Leea and Yeon Ja Choia and Do Hyun Kima and Pusoon Chunc and Hyung Ryong Moona and Hae Young Chunga and aCollege of Pharmacy and cCollege of Pharmacy and Inje University and bMolecular Inflammation Research Centor for Ageing Intervention (MRCA and Pusan National University
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 8, pp. 1227 - 1233
Inhibiting tyrosinase is an important goal to prevent melanin accumulation in skin and thereby to inhibit pigmentation disorders. Therefore, tyrosinase... 
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7. Full Text Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
by Kim, YJ and Uyama, H
CELLULAR AND MOLECULAR LIFE SCIENCES, ISSN 1420-682X, 08/2005, Volume 62, Issue 15, pp. 1707 - 1723
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders,... 
SLOW-BINDING INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | melanogenesis | food browning | KOJIC ACID | tyrosinase | MAMMALIAN MELANOGENESIS | CELL BIOLOGY | hyperpigmentation | MELANIN BIOSYNTHESIS PATHWAY | inhibitor | AGARICUS-BISPORUS TYROSINASE | MUSHROOM TYROSINASE | POLYPHENOL OXIDASE | COPPER ACTIVE-SITE | DOPAMINE BETA-MONOOXYGENASE | NEUROSPORA-CRASSA
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8. Full Text Gynostemma pentaphyllum saponins induce melanogenesis and activate of cAMP/PKA and Wnt/β-catenin signaling pathways
by Tsang, Ting-Fung and Chan, Brandon and Tai, William Chi-Shing and Huang, Guoxin and Wang, Jingrong and Li, Xiaoang and Jiang, Zhi Hong and Hsiao, W L Wendy
Phytomedicine : international journal of phytotherapy and phytopharmacology, ISSN 0944-7113, 07/2019, p. 153008
Melanogenesis is a physiological process of melanin production in response to UV exposure, which is modulated through multi-signaling pathways including... 
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9. Full Text Od tyrozyny do melaniny: Ścieżki sygnalizacyjne i czynniki regulujace melanogenezȩ
by Rzepka, Zuzanna and Buszman, Ewa and Beberok, Artur and Wrześniok, Dorota
Postepy Higieny i Medycyny Doswiadczalnej, ISSN 0032-5449, 2016, Volume 70, pp. 695 - 708
Melanocyte | Melanogenesis | Melanosome | Melanin
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10. Full Text Exploitation of Long-Lived (IL)-I-3 Excited States for Metal-Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model
by Lincoln, R and Kohler, L and Monro, S and Yin, HM and Stephenson, M and Zong, RF and Chouai, A and Dorsey, C and Hennigar, R and Thummel, RP and McFarland, SA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 11/2013, Volume 135, Issue 45, pp. 17161 - 17175
Members of a family of Ru(II)-appended pyrenylethynylene dyads were synthesized, characterized according to their photophysical and photobiological properties,... 
TRIPLET ENERGY-TRANSFER | PYRENYLETHYNYLENE SUBUNITS | LUMINESCENCE | PHOTOSENSITIZED GENERATION | RUTHENIUM COMPLEXES | PHOTOPHYSICS | SINGLET OXYGEN | MELANOGENESIS | DYADS | CHEMISTRY, MULTIDISCIPLINARY | LIFETIME
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11. Full Text Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng
by Dae-Young Leea and Sang Chul Jeongb and Yong Tae Jeongb and Mi-Kyoung Leec and Kyeong-Hwa Seod and Jae-Won Leea and Geum-Soog Kima and Seung-Eun Leea and Nam-In Baekd and Jin Hee Kime and College of Oriental Medicine and dDepartment of Oriental Medicinal Materials and Processing and bHK BIO and Daegu Haany University and cCancer Preventive Material Development Research Center and National Institute of Horticultural and Herbal Science and RDA and Business Incubator and Kyung Hee University and eCollege of Herbal Bio-industry and aDepartment of Herbal Crop Research
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 10, pp. 1663 - 1667
This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated... 
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12. Full Text Hair Follicle Pigmentation
by Slominski, Andrzej and Wortsman, Jacobo and Plonka, Przemyslaw M and Schallreuter, Karin U and Paus, Ralf and Tobin, Desmond J
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2005, Volume 124, Issue 1, pp. 13 - 21
Hair shaft melanin components (eu- or/and pheomelanin) are a long-lived record of precise interactions in the hair follicle pigmentary unit, e.g., between... 
follicular melanocytes | melanogenesis | hair pigmentation | melanin | Hair pigmentation | Follicular melanocytes | Melanogenesis | Melanin | OUTER ROOT SHEATH | MELANOCYTE PRECURSORS | DERMATOLOGY | MELANOSOME BIOGENESIS | L-DOPA | STEM-CELL FACTOR | PROTEINS | L-TYROSINE | CYCLE | Hair Follicle - physiology | Hair Follicle - cytology | Animals | Melanocytes - physiology | Humans | Hair Color - physiology | BMP, bone morphogenic proteins | EPR, electron paramagnetic resonance | OCA, oculocutaneous albinism | l-dopa | l-3,4-dihydroxyphenylalanine | PAH, phenylalanine hydroxylase | MSH, melanocyte stimulating hormone | TRP, tyrosinase-related protein | SCF, stem cell factor | DHI, dihydroxyindole | MRP, melanogenesis-related proteins | PAR2, protease-activated receptor 2 | CTSL, cysteine protease cathepsin L | ROS, reactive oxygen species | MIF, macrophage migration inhibitory factor | DHICA, dihydroxy-indole carboxylic acid | FM, follicular melanogenesis | CRH, corticotropin releasing hormone | DP, dermal papilla | TGN, trans-Golgi network | MITF, microphtalmia-associated transcription factor | DCT, dopa-chrome tautomerase | ASP, agouti protein | COMT, catechol-O-methyltransferase | DHICA-CF, DHICA conversion factor | MC1, melanocortin receptor 1 | ER, endoplasmic reticulum | ET, endothelin
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13. Full Text Baicalein inhibits melanogenesis through activation of the ERK signaling pathway
by Li, Xiaohong and Guo, Lei and Sun, Yan and Zhou, Jing and Gu, Yanli and Li, Yuzhen
International Journal of Molecular Medicine, ISSN 1107-3756, 06/2010, Volume 25, Issue 6, pp. 923 - 927
Baicalein | ERK signaling | Melanogenesis
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14. Full Text The role and mechanism of Asian medicinal plants in treating skin pigmentary disorders
by Li, Yumeng and Huang, Jinhua and Lu, Jianyun and Ding, Yufang and Jiang, Ling and Hu, Shuanghai and Chen, Jing and Zeng, Qinghai
Journal of Ethnopharmacology, ISSN 0378-8741, 12/2019, Volume 245, p. 112173
Chloasma, senile plaques, vitiligo and other pigmentary disorders seriously affect patients’ appearance and life quality. Medicinal plant is the product of... 
Melanogenesis | Tyrosinase | Pigmentary disorders | Medicinal plant
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15. Full Text Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway
by Lv, Jinpeng and Fu, Ying and Gao, Rongyin and Li, Jiawen and Kang, Maofan and Song, Guoqiang and Yun, Changjun
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 11/2019, Volume 116, p. 105620
Diazepam is a medicament of the benzodiazepine family and it typically produces a sedative effect. Researchers have revealed that diazepam can induce... 
PBR | Melanogenesis | Melanosome transport | cAMP/PKA | Diazepam
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16. Full Text upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo
by Niu, Chao and Aisa, Haji A
Molecules, ISSN 1420-3049, 08/2017, Volume 22, Issue 8, p. 1303
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called... 
Vitiligo | Analogues | Natural products | Synthesized derivatives | Tyrosinase activity | Melanogenesis | Plant extracts | synthesized derivatives | plant extracts | BIOCHEMISTRY & MOLECULAR BIOLOGY | melanogenesis | vitiligo | ENHANCES MELANOGENESIS | CHEMISTRY, MULTIDISCIPLINARY | analogues | B16 MELANOMA-CELLS | BIOACTIVE FLAVONOIDS | natural products | tyrosinase activity | IN-VITRO | CHALCONE DERIVATIVES | KINASE-A ACTIVATION | BIOLOGICAL EVALUATION | POLYGONI-MULTIFLORI | EXTRACT STIMULATES MELANOGENESIS | LEAF EXTRACT | Plant Extracts - chemistry | Animals | Enzyme Activators - therapeutic use | Enzyme Activators - chemistry | Humans | Vitiligo - drug therapy | Plant Extracts - therapeutic use | Vitiligo - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Proteins | Eye | Hair | Stimulators | Melanocytes | Skin | Pigmentation | Tyrosinase | Melanin
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17. Full Text From bench to counter: Discovery and validation of a paeonia extract as tyrosinase inhibiting cosmeceutical
by Rainer, Bettina and Revoltella, Silvia and Mayr, Fabian and Moesslacher, Julia and Scalfari, Valentina and Kohl, Roland and Waltenberger, Birgit and Pagitz, Konrad and Siewert, Bianka and Schwaiger, Stefan and Stuppner, Hermann
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, p. 111738
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18. Full Text 2-(3, 4-dihydroxybenzylidene)malononitrile as a novel antimelanogenic compound
by Lee, Bonggi and Moon, Kyoung Mi and Lim, Jong Seung and Park, Yeojin and Kim, Do Hyun and Son, Sujin and Jeong, Hyoung Oh and Kim, Dae Hyun and Lee, Eun Kyeong and Chung, Ki Wung and An, Hye Jin and Chun, Pusoon and Seo, Arnold Y and Yang, Ju-Hye and Lee, Bong-Seon and Ma, Jin Yeul and Cho, Won-Kyung and Moon, Hyung Ryong and Chung, Hae Young
Oncotarget, 2017, Volume 8, Issue 53, pp. 91481 - 91493
Skin | Melanogenesis | Tyrosinase inhibitor | Photoaging | Pigmentation
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19. Full Text The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light-induced oxidative stress
by Nahhas, Amanda F and Abdel-Malek, Zalfa A and Kohli, Indermeet and Braunberger, Taylor L and Lim, Henry W and Hamzavi, Iltefat H
Photodermatology Photoimmunology and Photomedicine, ISSN 0905-4383, 2018
Oxidative stress is an integral element that influences a variety of biochemical reactions throughout the body and is known to play a notable role in... 
ultraviolet radiation | melanogenesis | hyperpigmentation | visible light | antioxidants
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20. Full Text Spectroscopic characterization of natural melanin from a Streptomyces cyaneofuscatus strain and comparison with melanin enzymatically synthesized by tyrosinase and laccase
by Khatib, Maher Al and Harir, Mohamed and Costa, Jessica and Baratto, Maria Camilla and Schiavo, Irene and Trabalzini, Lorenza and Pollini, Simona and Rossolini, Gian Maria and Basosi, Riccardo and Pogni, Rebecca
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 8, p. 1916
An actinobacteria strain was isolated from Algerian Sahara soil and assigned to Streptomyces cyaneofuscatus Pridham et al. 1958 species. This strain was... 
Melanin spectral characterization | Melanogenesis enzymes | Radical species | Multifrequency electron paramagnetic resonance (EPR) | S. cyaneofuscatus Pridham et al. 1958 melanin | melanin spectral characterization | HAIR | EPR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPIN-RESONANCE SPECTROSCOPY | RATIO | radical species | MELANOGENESIS | multifrequency electron paramagnetic resonance (EPR) | CHEMISTRY, MULTIDISCIPLINARY | 1958 melanin | melanogenesis enzymes | FREE-RADICALS | S. cyaneofuscatus Pridham et al | BIOSYNTHESIS | EUMELANIN | BACTERIAL TYROSINASES | PHEOMELANINS | Streptomyces - metabolism | Electron Spin Resonance Spectroscopy | Spectroscopy, Fourier Transform Infrared | Melanins - metabolism | Laccase - metabolism | Monophenol Monooxygenase - metabolism | Dihydroxyphenylalanine | Spectroscopy | Enzymes | Fourier transforms | Fourier transformation | Free radicals | Organic chemistry | Pigments | Oxidation | Electron paramagnetic resonance | Dopa | Tyrosinase | Melanin | Laccase
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