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ACS Nano, ISSN 1936-0851, 04/2014, Volume 8, Issue 4, pp. 3636 - 3645
Journal Article
Cancer Research, ISSN 0008-5472, 01/2009, Volume 69, Issue 1, pp. 369 - 378
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2010, Volume 120, Issue 11, pp. 3953 - 3968
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2011, Volume 187, Issue 4, pp. 1970 - 1976
Macrophage secretion of vascular endothelial growth factor (VEGF) in response to the hypoxic tumor microenvironment contributes to tumor growth, angiogenesis,... 
CELLS | MELANOMA | HIF-2-ALPHA | VEGF | HIF-1-ALPHA | IMMUNOLOGY | EXPRESSION | CANCER | PROGRESSION | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Lung Neoplasms - metabolism | Neoplasm Proteins - immunology | Lung Neoplasms - pathology | Vascular Endothelial Growth Factor A - metabolism | Neoplasm Proteins - metabolism | Vascular Endothelial Growth Factor A - genetics | Oxygen - metabolism | Neovascularization, Pathologic - pathology | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Lung Neoplasms - secondary | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Melanoma - genetics | Vascular Endothelial Growth Factor Receptor-1 - immunology | Neovascularization, Pathologic - immunology | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Macrophages - immunology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - immunology | Lung Neoplasms - genetics | Melanoma - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Macrophages - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation, Neoplastic - immunology | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Oxygen - immunology | Melanoma - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Lung Neoplasms - immunology | Macrophages - metabolism | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Melanoma - immunology | Oxygen Consumption - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Transcription Factors - immunology | Neovascularization, Pathologic - genetics | Oxygen Consumption - immunology | Mice | Neovascularization, Pathologic - metabolism
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1492 - 16
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2014, Volume 135, Issue 5, pp. 1060 - 1071
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different transporters deliver each... 
LAT1 | melanoma | ASCT2 | mTORC1 | amino acid transport | APOPTOSIS | SIGNALING PATHWAYS | AMINO-ACID-TRANSPORT | KINASE | CANCER | IN-VITRO | ONCOLOGY | TRANSFER-RNA SYNTHETASE | RESISTANCE | EXPRESSION | RNA, Small Interfering - genetics | Minor Histocompatibility Antigens | Humans | Glutamine - metabolism | Multiprotein Complexes - genetics | CDC2 Protein Kinase - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Biological Transport | RNA Interference | Amino Acid Transport System ASC - genetics | Tumor Cells, Cultured | Spheroids, Cellular | Melanoma - metabolism | Skin Neoplasms - pathology | Leucine - metabolism | Amino Acids, Cyclic - pharmacology | Signal Transduction | Cell Survival | Serine - analogs & derivatives | Carrier Proteins - biosynthesis | Carrier Proteins - antagonists & inhibitors | Amino Acid Transport System ASC - antagonists & inhibitors | Melanoma - pathology | Skin Neoplasms - metabolism | Carrier Proteins - genetics | Large Neutral Amino Acid-Transporter 1 - biosynthesis | Benzyl Compounds - pharmacology | Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins B-raf - genetics | Serine - pharmacology | Cell Proliferation - drug effects | Ubiquitin-Conjugating Enzymes - biosynthesis | Amino Acid Transport System ASC - biosynthesis | Physiological aspects | Melanoma | Glutamine | Amino acids | Cell growth | Cell cycle
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2008, Volume 1131, Issue 1, pp. 225 - 234
The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and... 
lymphangiogenesis | lymphatic vessel | cancer | angiogenesis | lymph node | Angiogenesis | Lymph node | Lymphangiogenesis | Lymphatic vessel | Cancer | ENDOTHELIAL-GROWTH-FACTOR | FACTOR-C EXPRESSION | MULTIDISCIPLINARY SCIENCES | VEGF-C | MELANOMA METASTASIS | CELL LUNG-CANCER | BREAST-CANCER | NODE METASTASIS | RECEPTOR TYROSINE KINASES | PROMOTES TUMOR-METASTASIS | IN-VIVO | Lymph Nodes - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor Receptor-2 - immunology | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Lymph Nodes - blood supply | Lymphatic Metastasis - pathology | Neovascularization, Pathologic - prevention & control | Vascular Endothelial Growth Factor D - genetics | Signal Transduction | Lymphangiogenesis - physiology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Vascular Endothelial Growth Factor D - metabolism | Animals | Lymphatic Metastasis - prevention & control | Models, Biological | Vascular Endothelial Growth Factor C - metabolism | Lymphatic Vessels - pathology | Vascular Endothelial Growth Factor Receptor-3 - genetics | Endothelial growth factors | Metastasis
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 139, Issue 3, pp. 1030 - 1040
Background & Aims Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular... 
Gastroenterology and Hepatology | Cancer Therapy | Ectonucleoside Triphosphate Diphosphohydrolase-1 | Liver | Regulatory T Cell (Treg) | NATURAL-KILLER-CELLS | NK-CELLS | RECEPTOR | CYTOTOXIC ACTIVITY | CD39-NULL MICE | ADENOSINE-MEDIATED INHIBITION | CYTOKINE PRODUCTION | IMMUNE SUPPRESSION | IN-VIVO | CD39 | GASTROENTEROLOGY & HEPATOLOGY | Colonic Neoplasms - genetics | Tumor Escape | Colonic Neoplasms - drug therapy | Melanoma, Experimental - drug therapy | Male | Tungsten Compounds - pharmacology | Antigens, CD - genetics | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Melanoma, Experimental - immunology | Time Factors | Colonic Neoplasms - immunology | Forkhead Transcription Factors - metabolism | Melanoma, Experimental - secondary | Bone Marrow Transplantation | Killer Cells, Natural - immunology | Antineoplastic Agents - pharmacology | Liver Neoplasms - secondary | Apyrase - antagonists & inhibitors | Liver Neoplasms - genetics | Mice, Inbred C57BL | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Liver Neoplasms - drug therapy | Colonic Neoplasms - secondary | Liver Neoplasms - immunology | Radiation Chimera | Lymphocytes, Tumor-Infiltrating - drug effects | Tumor Burden | Forkhead Transcription Factors - genetics | Apyrase - deficiency | Mice, Knockout | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Apyrase - genetics | Cell Line, Tumor | Mice | Cytotoxicity, Immunologic | Lymphocytes, Tumor-Infiltrating - immunology | ENTPD1 | Regulatory T cells (Treg) | Cancer therapy
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article