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The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 5, pp. 2046 - 2058
... (TILs) from patients with melanoma, and these TIGIT-expressing CD8(+) T cells often coexpress the inhibitory receptor PD-1. Moreover, CD8... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2017, Volume 114, Issue 19, pp. 4993 - 4998
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 359, Issue 6371, pp. 97 - 103
Journal Article
Medicine, ISSN 0025-7974, 01/2017, Volume 96, Issue 1, p. e5753
...) and the anorectal region. The aim of this study was to evaluate clinics, prognosis, and treatment options of patients with mucosal melanoma, in particular with regard to different primary sites... 
Prognosis | Targeted therapy | Immunotherapy | CTLA-4 | PD-1 inhibitor | Radiotherapy | Mucosal melanoma | targeted therapy | NODE BIOPSY | PHASE-II | MALIGNANT-MELANOMA | prognosis | CANCER | METASTATIC MELANOMA | MEDICINE, GENERAL & INTERNAL | immunotherapy | radiotherapy | mucosal melanoma | MUTATIONS | SKIN | EPIDEMIOLOGY | IPILIMUMAB | KIT EXPRESSION | Age Factors | Humans | Ipilimumab | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Young Adult | Rectal Neoplasms - genetics | Melanoma - genetics | Aged, 80 and over | Anus Neoplasms - therapy | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Rectal Neoplasms - pathology | Retrospective Studies | Radiotherapy, Adjuvant | Intestinal Mucosa | Head and Neck Neoplasms - therapy | Neoplasm Recurrence, Local | Survival Rate | Anus Neoplasms - pathology | Lymphatic Metastasis | Mouth Mucosa | Rectal Neoplasms - therapy | Melanoma - secondary | Head and Neck Neoplasms - pathology | Disease-Free Survival | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Anus Neoplasms - genetics | Head and Neck Neoplasms - genetics | Indoles - therapeutic use | Aged | Melanoma - therapy | Neoplasm Staging | Care and treatment | Usage | Gene mutations | Melanoma | Research
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 359, Issue 6371, pp. 104 - 108
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 547, Issue 7662, pp. 217 - 221
...-existing neoantigen-specific T-cell populations and induce a broader repertoire of new T-cell specificities in cancer patients, tipping the intra-tumoural balance... 
IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CD4(+) T-CELLS | ANTIGENS | CANCER-IMMUNOTHERAPY | SEQUENCING DATA | EXPRESSION | PEPTIDE | PREDICTION | MOLECULES | EPITOPES | Amino Acid Sequence | Antigens, Neoplasm - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Neoplasm Recurrence, Local - prevention & control | Antigens, Neoplasm - immunology | Humans | Cancer Vaccines - adverse effects | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Cancer Vaccines - chemistry | Antigens, Neoplasm - chemistry | Machine Learning | CD4-Positive T-Lymphocytes - immunology | Neoplasm Recurrence, Local - immunology | Cancer Vaccines - immunology | Histocompatibility Antigens Class II - immunology | Melanoma - genetics | Melanoma - immunology | Antibodies, Monoclonal, Humanized - pharmacology | Patient Safety | High-Throughput Nucleotide Sequencing | Mutation | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Precision Medicine - methods | Care and treatment | Methods | Melanoma | Cancer | Peptides | PD-1 protein | CD8 antigen | Vaccination | Lymphocytes T | Vaccines | Tissues | Immunity | Thymus | Lymphocytes | Immunotherapy | Antigens | Feasibility studies | T cell receptors | Gene expression | Patients | Immunological tolerance | CD4 antigen | Studies | Immune checkpoint | Immunogenicity | Cell death | Histocompatibility antigen HLA | Tumors | Apoptosis
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 6, pp. 2350 - 2360
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 26, pp. 2455 - 2465
... (at escalating doses ranging from 0.3 to 10 mg per kilogram of body weight) to patients with selected advanced cancers... 
MEDICINE, GENERAL & INTERNAL | IMMUNOTHERAPY | GUIDELINES | B7 FAMILY | B7-H1 | CTLA-4 | LIGAND | BLOCKADE | CLINICAL ACTIVITY | PHASE-I | PD-1 | Neoplasms - metabolism | Humans | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Adult | Female | Carcinoma, Renal Cell - drug therapy | Ovarian Neoplasms - drug therapy | Programmed Cell Death 1 Receptor - metabolism | Stomach Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Antibodies, Monoclonal - administration & dosage | Melanoma - drug therapy | Nivolumab | Carcinoma, Non-Small-Cell Lung - drug therapy | Programmed Cell Death 1 Receptor - immunology | Intravenous administration | Kidneys | Immune response | Disease | PD-1 protein | Tumor cells | Colorectal carcinoma | Body weight | Melanoma | Lymphocytes T | Breast cancer | Stomach cancer | Patients | Ovarian cancer | Lungs | Pancreatic cancer | PD-L1 protein | Antitumor activity | Ligands | Autoimmune diseases | Gastric cancer | Clear cell-type renal cell carcinoma | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
Journal Article