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humans (245) 245
animals (208) 208
trypanosomiasis, african - drug therapy (194) 194
science & technology (186) 186
life sciences & biomedicine (182) 182
melarsoprol - therapeutic use (158) 158
melarsoprol (146) 146
biological and medical sciences (115) 115
medical sciences (114) 114
trypanocidal agents - therapeutic use (106) 106
trypanosomiasis (104) 104
female (101) 101
male (98) 98
parasitic diseases (95) 95
tropical medicine (93) 93
infectious diseases (83) 83
melarsoprol - pharmacology (74) 74
trypanosoma brucei gambiense (69) 69
mice (68) 68
adult (67) 67
trypanocidal agents - pharmacology (62) 62
parasitology (60) 60
protozoal diseases (59) 59
human protozoal diseases (58) 58
pharmacology. drug treatments (58) 58
antiparasitic agents (56) 56
drug resistance (56) 56
melarsoprol - administration & dosage (50) 50
melarsoprol - adverse effects (48) 48
trypanosomiasis, african - parasitology (47) 47
middle aged (46) 46
african trypanosomiasis (45) 45
antibiotics. antiinfectious agents. antiparasitic agents (45) 45
eflornithine - therapeutic use (44) 44
human african trypanosomiasis (44) 44
adolescent (43) 43
public, environmental & occupational health (43) 43
pentamidine - therapeutic use (39) 39
suramin - therapeutic use (39) 39
sleeping sickness (37) 37
trypanosomiasis, african - epidemiology (36) 36
arsenicals - therapeutic use (35) 35
trypanocidal agents - administration & dosage (35) 35
trypanosoma brucei brucei - drug effects (35) 35
recurrence (34) 34
trypanosomiasis, african - diagnosis (34) 34
child (33) 33
drug therapy, combination (32) 32
pentamidine (32) 32
trypanosoma brucei rhodesiense (30) 30
eflornithine (29) 29
suramin (28) 28
abridged index medicus (26) 26
pharmacology & pharmacy (26) 26
pentamidine - pharmacology (25) 25
trypanosoma brucei (25) 25
trypanosoma brucei gambiense - drug effects (25) 25
chemotherapy (24) 24
drug therapy (24) 24
treatment outcome (24) 24
trypanocidal agents - adverse effects (23) 23
child, preschool (22) 22
trypanosoma brucei brucei (22) 22
old medline (21) 21
trypanosoma brucei rhodesiense - drug effects (21) 21
trypanosomiasis, african (21) 21
aged (20) 20
arsenicals - pharmacology (20) 20
microbiology (20) 20
parasites (20) 20
suramin - pharmacology (20) 20
drug administration schedule (19) 19
treatment failure (19) 19
trypanosomiasis, african - prevention & control (19) 19
general aspects (18) 18
research article (18) 18
trypanocidal agents - pharmacokinetics (18) 18
follow-up studies (17) 17
time factors (17) 17
trypanosoma brucei brucei - metabolism (17) 17
trypanosomiasis, african - complications (17) 17
general & internal medicine (16) 16
medicine, general & internal (16) 16
nifurtimox - therapeutic use (16) 16
trypanocidal agents (16) 16
trypanosomiasis, african - cerebrospinal fluid (16) 16
analysis (15) 15
biochemistry & molecular biology (15) 15
immunology (15) 15
melarsoprol - pharmacokinetics (15) 15
nifurtimox (15) 15
research (15) 15
trypanosomiasis - drug therapy (15) 15
arsenic (14) 14
arsenicals - adverse effects (14) 14
infant (14) 14
trypanosomiasis, african - mortality (14) 14
diminazene - pharmacology (13) 13
drugs (13) 13
eflornithine - administration & dosage (13) 13
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1. Full Text Equivalence Trial of Melarsoprol and Nifurtimox Monotherapy and Combination Therapy for the Treatment of Second-Stage Trypanosoma brucei gambiense Sleeping Sickness
by Sylvie Bisser and François-Xavier N'Siesi and Veerle Lejon and Pierre-Marie Preux and Simon Van Nieuwenhove and Constantin Miaka Mia Bilenge and Philippe Büscher
The Journal of infectious diseases, ISSN 0022-1899, 2/2007, Volume 195, Issue 3, pp. 322 - 329
Relapse | Health care administration | Encephalopathies | Cerebrospinal fluid | Parasites | Dosage | Patient assessment | Trypanosomiasis | African trypanosomiasis | Blood | Trypanosome | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Recurrence | Trypanosomiasis, African - drug therapy | Injections, Intravenous | Drug Administration Schedule | Administration, Oral | Humans | Melarsoprol - administration & dosage | Male | Melarsoprol - therapeutic use | Treatment Outcome | Trypanosoma brucei gambiense | Brain Diseases - chemically induced | Melarsoprol - adverse effects | Animals | Adult | Female | Trypanocidal Agents - therapeutic use | Drug Therapy, Combination | Nifurtimox - therapeutic use | Sleep disorders | Care and treatment | Patient outcomes | Causes of | Research | Trypanosoma brucei | Drug therapy | Index Medicus | Abridged Index Medicus | Parasitology | Nifurtimox | Melarsoprol | Trypanosomiasis, African | Life Sciences | Microbiology and Parasitology | Trypanocidal Agents | Brain Diseases | Santé publique et épidémiologie
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2. Full Text Determination of the trypanocidal drug melarsoprol and its conversion products in biological fluids with HPLC–ICPMS/ESMS
by Raber, Georg and Raber, Thomas and Raml, Reingard and Murko, Manuela and Magnes, Christoph and Francesconi, Kevin A
Talanta (Oxford), ISSN 0039-9140, 11/2013, Volume 116, pp. 876 - 881
HPLC–ICPMS/ESMS | Melarsoprol | Sleeping sickness | Arsenic | HPLC-ICPMS/ESMS | Melarsoprol Sleeping sickness | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Trypanocidal Agents - blood | Limit of Detection | Melarsoprol - pharmacology | Serum - metabolism | Drug Stability | Humans | Cells, Cultured | Blood Cells - metabolism | Trypanocidal Agents - chemistry | Blood Proteins - chemistry | Chromatography, High Pressure Liquid | Spectrophotometry, Atomic | Blood Cells - cytology | Spectrometry, Mass, Electrospray Ionization | Trypanocidal Agents - pharmacology | Biotransformation | Arsenicals - chemistry | Melarsoprol - chemistry | Protein Binding | Arsenic - blood | Arsenicals - blood | Blood Cells - drug effects | Melarsoprol - blood | Serum - chemistry | Proteins | Arson | Metabolites | Rain and rainfall | Protein binding | Index Medicus
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3. Full Text Comparison of nanosuspensions and hydroxypropyl-β-cyclodextrin complex of melarsoprol: Pharmacokinetics and tissue distribution in mice
by Ben Zirar, Siham and Astier, Alain and Muchow, Marc and Gibaud, Stéphane
European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, 2008, Volume 70, Issue 2, pp. 649 - 656
Melarsoprol | Cyclodextrin | Nanosuspensions | Arsenic | Leukemia | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | 2-Hydroxypropyl-beta-cyclodextrin | Melarsoprol - pharmacology | Humans | Lethal Dose 50 | Trypanocidal Agents - pharmacokinetics | Chemistry, Pharmaceutical | Nanoparticles | Tissue Distribution | Animals | beta-Cyclodextrins - chemistry | Melarsoprol - pharmacokinetics | U937 Cells | K562 Cells | Melarsoprol - chemistry | Female | Antineoplastic Agents - pharmacology | Mice | Suspensions | Index Medicus | Antineoplastic Agents | Life Sciences | beta-Cyclodextrins | Trypanocidal Agents | Pharmaceutical sciences
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4. Full Text Human African trypanosomiasis
by Brun, Reto, Prof and Blum, Johannes, MD and Chappuis, Francois, MD and Burri, Christian, PhD
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 375, Issue 9709, pp. 148 - 159
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Infectious diseases | Parasitic diseases | Protozoal diseases | Biological and medical sciences | Human protozoal diseases | Medical sciences | Trypanosomiasis | Africa - epidemiology | Insect Vectors | Tsetse Flies - parasitology | Humans | Pentamidine - therapeutic use | Trypanosoma brucei gambiense - pathogenicity | Trypanosoma brucei gambiense - immunology | Melarsoprol - therapeutic use | Insect Bites and Stings - prevention & control | Eflornithine - therapeutic use | Communicable Disease Control - methods | Incidence | Variant Surface Glycoproteins, Trypanosoma - immunology | Trypanosomiasis, African - transmission | Animals | Trypanosomiasis, African - diagnosis | Suramin - therapeutic use | Trypanosomiasis, African - epidemiology | Biomedical Research | Trypanocidal Agents - therapeutic use | Endemic Diseases - prevention & control | Trypanosomiasis, African - therapy | Drugs | Insects | Medical diagnosis | Rural areas | Health services | Tropical diseases | Index Medicus | Abridged Index Medicus
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5. Full Text The phenomenon of treatment failures in Human African Trypanosomiasis
by Brun, Reto and Schumacher, Reto and Schmid, Cecile and Kunz, Christina and Burri, Christian
Tropical medicine & international health, ISSN 1360-2276, 11/2001, Volume 6, Issue 11, pp. 906 - 914
treatment | drug resistance | relapse | Trypanosoma brucei gambiense | Trypanosoma brucei rhodesiense | melarsoprol | Melarsoprol | Relapse | Treatment | Drug resistance | Biological and medical sciences | Antiparasitic agents | Tropical medicine | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Recurrence | Trypanocidal Agents - blood | Trypanosomiasis, African - drug therapy | Parasitic Sensitivity Tests | Humans | Melarsoprol - therapeutic use | Dose-Response Relationship, Drug | Trypanosoma brucei gambiense - drug effects | Treatment Failure | Trypanosomiasis, African - epidemiology | Trypanocidal Agents - cerebrospinal fluid | Trypanocidal Agents - therapeutic use | Trypanosoma brucei gambiense - isolation & purification | Africa, Eastern - epidemiology | Drug Resistance | Melarsoprol - cerebrospinal fluid | Trypanosoma brucei rhodesiense - isolation & purification | Trypanocidal Agents - pharmacokinetics | Trypanosomiasis, African - parasitology | Animals | Melarsoprol - pharmacokinetics | Muridae | Mice | Trypanosoma brucei rhodesiense - drug effects | Melarsoprol - blood | Index Medicus
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6. Full Text Melarsoprol–cyclodextrins inclusion complexes
by Gibaud, Stéphane and Zirar, Siham Ben and Mutzenhardt, Pierre and Fries, Isabelle and Astier, Alain
International journal of pharmaceutics, ISSN 0378-5173, 2005, Volume 306, Issue 1, pp. 107 - 121
Melarsoprol | Complexation | Cytotoxicity | Hydroxypropyl-β-cyclodextrin | Nuclear magnetic resonance | Methylated-β-cyclodextrin | Hydroxypropyl-β- cyclodextrin | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Cell Survival - drug effects | Magnetic Resonance Spectroscopy | Melarsoprol - pharmacology | Drug Stability | Humans | Solubility | Antineoplastic Agents - chemistry | Cyclodextrins - chemistry | Cell Line, Tumor | Drug Compounding | Melarsoprol - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Kinetics | Cyclodextrins - pharmacology | Hydrolysis | Antiparasitic agents | Cyclodextrins | Analysis | Leukemia | Index Medicus | Cell Survival | Antineoplastic Agents | Life Sciences | Pharmaceutical sciences
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7. Full Text Treatment of human African trypanosomiasis—present situation and needs for research and development
by Legros, Dominique and Ollivier, Gaëlle and Gastellu-Etchegorry, Marc and Paquet, Christophe and Burri, Christian and Jannin, Jean and Büscher, Philippe
The Lancet infectious diseases, ISSN 1473-3099, 2002, Volume 2, Issue 7, pp. 437 - 440
Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - adverse effects | Nifurtimox - administration & dosage | Humans | Trypanosoma brucei rhodesiense | Africa South of the Sahara | Melarsoprol - administration & dosage | Eflornithine - adverse effects | Melarsoprol - therapeutic use | Eflornithine - therapeutic use | Trypanosoma brucei gambiense | Melarsoprol - adverse effects | Animals | Nifurtimox - adverse effects | Thiadiazoles - therapeutic use | Benzamidines - therapeutic use | Trypanocidal Agents - therapeutic use | Drug Therapy, Combination | Eflornithine - administration & dosage | Nifurtimox - therapeutic use | Trypanocidal Agents - administration & dosage | Index Medicus
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8. Full Text Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters
by Schumann Burkard, Gabriela and Jutzi, Pascal and Roditi, Isabel
Molecular and biochemical parasitology, ISSN 0166-6851, 2011, Volume 175, Issue 1, pp. 91 - 94
Melarsoprol | Amino acid | Trypanosoma brucei | Drug resistance | Transporter | Eflornithine | Biochemistry & Molecular Biology | Parasitology | Life Sciences & Biomedicine | Science & Technology | Melarsoprol - pharmacology | Trypanosoma brucei brucei - metabolism | Gene Silencing | Eflornithine - pharmacology | Trypanosoma brucei brucei - genetics | Protozoan Proteins - genetics | Antiprotozoal Agents - pharmacology | Gene Knockdown Techniques - methods | Trypanosoma brucei brucei - drug effects | Protozoan Proteins - metabolism | Transfection - methods | Membrane Transport Proteins - genetics | Membrane Transport Proteins - metabolism | Blood - parasitology | Antiparasitic agents | Amino acids | RNA | Genomics | Index Medicus | Adenosine
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9. Full Text High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo
by Robays, Jo and Nyamowala, Gaspard and Sese, Claude and Kande, Victor Betu Ku Mesu and Lutumba, Pascal and Van Der Veken, Wim and Boelaert, Marleen
Emerging infectious diseases, ISSN 1080-6040, 2008, Volume 14, Issue 6, pp. 966 - 967
Medicine, Experimental | Medical research | Care and treatment | Trypanosomiasis | Statistics | Index Medicus | treatment | Human African trypanosomiasis | dispatch | relapse | Congo | melarsoprol
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10. Full Text High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo
by Robays, Jo and Nyamowala, Gaspard and Sese, Claude and Kande, Victor Betu Ku Mesu and Lutumba, Pascal and Van der Veken, Wim and Boelaert, Marleen
Emerging infectious diseases, ISSN 1080-6040, 06/2008, Volume 14, Issue 6, pp. 966 - 967
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Recurrence | Trypanosomiasis, African - drug therapy | Humans | Middle Aged | Child, Preschool | Melarsoprol - administration & dosage | Trypanosomiasis, African - prevention & control | Infant | Male | Melarsoprol - therapeutic use | Trypanosomiasis, African - parasitology | Democratic Republic of the Congo - epidemiology | Animals | Treatment Failure | Adolescent | Adult | Female | Trypanocidal Agents - therapeutic use | Child | Trypanocidal Agents - administration & dosage | treatment | Dispatch | Human African trypanosomiasis | relapse | melarsoprol
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11. Full Text Eflornithine Is Safer than Melarsoprol for the Treatment of Second-Stage Trypanosoma brucei gambiense Human African Trypanosomiasis
by François Chappuis and Nitya Udayraj and Kai Stietenroth and Ann Meussen and Patrick A. Bovier
Clinical infectious diseases, ISSN 1058-4838, 9/2005, Volume 41, Issue 5, pp. 748 - 751
Brief Reports | Infectious diseases | Intravenous injections | Mortality | Diarrhea | Encephalopathies | Adverse effects | Dosage | African trypanosomiasis | Lymph nodes | Diseases | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Trypanosomiasis, African - drug therapy | Trypanocidal Agents - adverse effects | Humans | Eflornithine - adverse effects | Male | Melarsoprol - therapeutic use | Eflornithine - therapeutic use | Sudan - epidemiology | Melarsoprol - adverse effects | Trypanosomiasis, African - mortality | Adolescent | Adult | Female | Trypanocidal Agents - therapeutic use | Child | Dosage and administration | Drug therapy | Trypanosoma brucei | Eflornithine | Drugs | Health risk assessment | Comparative analysis | Medical treatment | Index Medicus
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12. Full Text Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
by Graf, Fabrice E and Ludin, Philipp and Arquint, Christian and Schmidt, Remo S and Schaub, Nadia and Kunz Renggli, Christina and Munday, Jane C and Krezdorn, Jessica and Baker, Nicola and Horn, David and Balmer, Oliver and Caccone, Adalgisa and de Koning, Harry P and Mäser, Pascal
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 09/2016, Volume 73, Issue 17, pp. 3387 - 3400
African trypanosomes | Melarsoprol | RNA-binding protein | Pentamidine | Purine permease | Aquaporin | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Parasitic Sensitivity Tests | Genome, Protozoan | Humans | Male | Nucleoside Transport Proteins - metabolism | Protozoan Proteins - genetics | Aquaporins - genetics | Protozoan Proteins - metabolism | Trypanosomiasis, African - diagnosis | Trypanosoma brucei rhodesiense - genetics | DNA, Protozoan - chemistry | Pentamidine - pharmacology | Amino Acid Sequence | DNA, Protozoan - isolation & purification | Melarsoprol - pharmacology | Nucleoside Transport Proteins - genetics | Aquaporins - metabolism | Trypanosoma brucei rhodesiense - isolation & purification | Drug Resistance - genetics | Trypanosomiasis, African - parasitology | Phenotype | Sequence Alignment | Comparative Genomic Hybridization | Trypanocidal Agents - pharmacology | DNA, Protozoan - metabolism | Heterozygote | Polymorphism, Single Nucleotide | Trypanosoma brucei rhodesiense - drug effects | RNA-Binding Proteins - metabolism | Evolutionary biology | RNA | Gene mutations | Aquaporins | Genomics | Genetic research | Drug resistance | Comparative analysis | Protein binding | Comparative studies | Parasitic protozoa | Pharmacology | Parasitic diseases | Index Medicus | Original
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