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1. Full Text Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T‐cell subsets in multiple sclerosis patients
by Sacramento, Priscila M and Monteiro, Clarice and Dias, Aleida S. O and Kasahara, Taissa M and Ferreira, Thaís B and Hygino, Joana and Wing, Ana Cristina and Andrade, Regis M and Rueda, Fernanda and Sales, Marisa C and Vasconcelos, Claudia Cristina and Bento, Cleonice A. M
European Journal of Immunology, ISSN 0014-2980, 08/2018, Volume 48, Issue 8, pp. 1376 - 1388
Excessive levels of proinflammatory cytokines in the CNS are associated with reduced serotonin (5‐HT) synthesis, a neurotransmitter with diverse immune... 
Treg subsets | Multiple sclerosis | Th1/Th17 axis | Serotonin | FOXP3 EXPRESSION | MELATONIN | RECEPTOR | MODEL | IMMUNOLOGY | Th17 axis | HUMAN MONOCYTES | TREG FUNCTION | INTERFERON-GAMMA | DISEASE | IMMUNE ACTIVATION | Th1 | TH17 | Evaluation | Cytokines | Analysis | Phenols | T cells | Cell proliferation | Brain | Immunoregulation | Pathogenesis | CD8 antigen | Helper cells | Central nervous system | Lymphocytes T | Inflammation | Patients | CD4 antigen | Demyelination | Lymphocytes | Foxp3 protein | Interferon | Lesions
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2. Full Text Identification of genes for melatonin synthetic enzymes in ‘Red Fuji’ apple (Malus domestica Borkh.cv.Red) and their expression and melatonin production during fruit development
by Lei, Qiong and Wang, Lin and Tan, Dun‐Xian and Zhao, Yu and Zheng, Xiao‐Dong and Chen, Hao and Li, Qing‐tian and Zuo, Bi‐xiao and Kong, Jin
Journal of Pineal Research, ISSN 0742-3098, 11/2013, Volume 55, Issue 4, pp. 443 - 451
Melatonin is present in many edible fruits; however, the presence of melatonin in apple has not previously been reported. In this study, the genes for... 
fruit development | apple | key genes | melatonin biosynthesis | N-ACETYLSEROTONIN METHYLTRANSFERASE | PHYSIOLOGY | CUCUMBER SEEDLINGS | INVOLVEMENT | CULTIVAR | NEUROSCIENCES | EDIBLE PLANTS | BIOSYNTHESIS | ENDOCRINOLOGY & METABOLISM | SENESCENCE | TRYPTAMINE | EXOGENOUS MELATONIN | RICE | Plant Proteins - genetics | Malus - metabolism | Gene Expression Regulation, Plant | Malus - enzymology | Melatonin - biosynthesis | Fruit - enzymology | Plant Proteins - metabolism | Fruit - metabolism | Enzymes | Apple | Melatonin | Analysis | Genes | Genetic research | Physiological aspects | Tryptophan | Aralkylamine N-acetyltransferase | Index Medicus
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3. Full Text STAT1‐NFκB crosstalk triggered by interferon gamma regulates noradrenaline‐induced pineal hormonal production
by Barbosa Lima, Leila Eliza and Muxel, Sandra Marcia and Kinker, Gabriela S and Carvalho‐Sousa, Cláudia Emanuele and Silveira Cruz‐Machado, Sanseray and Markus, Regina P and Fernandes, Pedro Augusto Carlos Magno
Journal of Pineal Research, ISSN 0742-3098, 10/2019, Volume 67, Issue 3, pp. e12599 - n/a
Melatonin production by pineal glands is modulated by several immune signals. The nuclear translocation of nuclear factor kappa‐B (NFκB) homodimers, lacking... 
immune‐pineal axis | melatonin | inflammation | IFN‐γ | pineal gland | IMMUNE-RESPONSE | PHYSIOLOGY | HUMAN COLOSTRUM | MELATONIN SYNTHESIS | BINDING PROTEIN | NEUROSCIENCES | IFN-gamma | PROTEIN-KINASE PKR | immune-pineal axis | ENDOCRINOLOGY & METABOLISM | TNF-ALPHA | NF-KAPPA-B | GLAND | ACETYLTRANSFERASE
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4. Full Text Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
by Slominski, Andrzej T and Slominski, Radomir M and Hardeland, Ruediger and Zmijewski, Michal A and Reiter, Russel J and Paus, Ralf
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2018, Volume 138, Issue 3, pp. 490 - 499
Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland.... 
OXIDATIVE DAMAGE | PINEAL HORMONE MELATONIN | TRYPTOPHAN-HYDROXYLASE | UV-INDUCED ERYTHEMA | TOPICAL TREATMENT | BINDING-SITE | SEROTONINERGIC SYSTEM | EXOGENOUS MELATONIN | MELANOMA GROWTH | HUMAN EPIDERMIS | DERMATOLOGY
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5. Full Text Melatonin inhibits Prevotella intermedia lipopolysaccharide‐induced production of nitric oxide and interleukin‐6 in murine macrophages by suppressing NF‐κB and STAT1 activity
by Choi, Eun‐Young and Jin, Ji‐Young and Lee, Ju‐Youn and Choi, Jeom‐Il and Choi, In Soon and Kim, Sung‐Jo
Journal of Pineal Research, ISSN 0742-3098, 03/2011, Volume 50, Issue 2, pp. 197 - 206
:  Although a range of biological and pharmacological activities of melatonin have been reported, little is known about its potential anti‐inflammatory... 
nitric oxide | Prevotella intermedia | lipopolysaccharide | melatonin | interleukin‐6 | periodontal disease | interleukin-6 | ACTIVATION | CYTOKINES | PHYSIOLOGY | GINGIVAL CREVICULAR FLUID | PROLIFERATION | NEUROSCIENCES | FACTOR-ALPHA | ACTINOBACILLUS-ACTINOMYCETEMCOMITANS | SYNTHASE EXPRESSION | IMMUNE-SYSTEM | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | DESTRUCTIVE PERIODONTAL-DISEASE | Cell Line | Interleukin-6 - genetics | NF-kappa B - metabolism | STAT1 Transcription Factor - genetics | Blotting, Western | Prevotella intermedia - chemistry | Macrophages - metabolism | STAT1 Transcription Factor - metabolism | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Lipopolysaccharides - pharmacology | Polymerase Chain Reaction | Macrophages - drug effects | Mice | Nitric Oxide - metabolism | Interleukin-6 - metabolism | Melatonin - pharmacology | Nitric Oxide Synthase Type II - metabolism
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6. Full Text Melatonin limited ethylene production, softening and reduced physiology disorder in pear (Pyrus communis L.) fruit during senescence
by Zhai, Rui and Liu, Fengxia and Liu, Jianlong and Liu, Lulu and Zhao, Yingxiao and Fang, Chen and Wang, Zhigang and Wang, Huibin and Li, Xieyu and Ma, Fengwang and Xu, Lingfei
Postharvest Biology and Technology, ISSN 0925-5214, 05/2018, Volume 139, pp. 38 - 46
Some pear ( L.) fruit show a certain resistance to ripening. Thus, postharvest cold storage is commonly used to accelerate their ripening process by promoting... 
Ripening | Melatonin | Ethylene reducing | Programmed cell death | TOMATO FRUIT | POSTHARVEST | AGRONOMY | HEMICELLULOSE | FOOD SCIENCE & TECHNOLOGY | ANTIOXIDANT ENZYMES | HORTICULTURE | CELL-WALL POLYSACCHARIDE | 1-METHYLCYCLOPROPENE | METABOLISM | GENE-EXPRESSION | PLANTS | STRESS TOLERANCE
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7. Full Text Chloroplast overexpression of rice caffeic acid O‐methyltransferase increases melatonin production in chloroplasts via the 5‐methoxytryptamine pathway in transgenic rice plants
by Choi, Geun‐Hee and Lee, Hyoung Yool and Back, Kyoungwhan
Journal of Pineal Research, ISSN 0742-3098, 08/2017, Volume 63, Issue 1, pp. e12412 - n/a
Recent analyses of the enzymatic features of various melatonin biosynthetic genes from bacteria, animals, and plants have led to the hypothesis that melatonin... 
caffeic acid O‐methyltransferase | senescence | chloroplast targeting | melatonin | transgenic rice | 5‐methoxytryptamine | caffeic acid O-methyltransferase | 5-methoxytryptamine | ACETYLSEROTONIN METHYLTRANSFERASE | PHYSIOLOGY | 2-HYDROXYMELATONIN | SUPPRESSION | NEUROSCIENCES | PROTOPORPHYRINOGEN OXIDASE | GENE | BIOSYNTHESIS | ENDOCRINOLOGY & METABOLISM | SEROTONIN N-ACETYLTRANSFERASE | STRESS | EXPRESSION | Cadmium | Melatonin - analysis | Plants, Genetically Modified - metabolism | Oryza - genetics | Plants, Genetically Modified - genetics | 5-Methoxytryptamine - metabolism | Oryza - metabolism | Methyltransferases - metabolism | Cloning, Molecular | Melatonin - metabolism | Chloroplasts - metabolism | Seedlings - metabolism | Biotechnology | Melatonin | Genetically engineered foods | Transferases | Genetic research | Genetic engineering | Plants | Food
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8. Full Text Overexpression of MzASMT improves melatonin production and enhances drought tolerance in transgenic Arabidopsis thaliana plants
by Zuo, Bixiao and Zheng, Xiaodong and He, Pingli and Wang, Lin and Lei, Qiong and Feng, Chao and Zhou, Jingzhe and Li, Qingtian and Han, Zhenhai and Kong, Jin
Journal of Pineal Research, ISSN 0742-3098, 11/2014, Volume 57, Issue 4, pp. 408 - 417
Melatonin is a potent naturally occurring reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenger in plants. Melatonin protects plants from... 
apple | drought tolerance | MzASMT1 | transgenic Arabidopsis | melatonin | ROS scavenger | Apple | Melatonin | Drought tolerance | Transgenic Arabidopsis | N-ACETYLSEROTONIN METHYLTRANSFERASE | PHYSIOLOGY | ROOT | CUCUMBER SEEDLINGS | NEUROSCIENCES | CELL-DEATH | REACTIVE OXYGEN | EDIBLE PLANTS | ANTIOXIDANT | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | EXOGENOUS MELATONIN | RICE | Acetylserotonin O-Methyltransferase - metabolism | Reactive Oxygen Species - metabolism | Stress, Physiological - genetics | Agriculture - methods | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Acetylserotonin O-Methyltransferase - genetics | Adaptation, Physiological - genetics | Droughts | Plants, Genetically Modified | Melatonin - biosynthesis | Melatonin - genetics | Arabidopsis thaliana | Genetic engineering
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9. Full Text Molecular cloning of melatonin 2‐hydroxylase responsible for 2‐hydroxymelatonin production in rice (Oryza sativa)
by Byeon, Yeong and Back, Kyoungwhan
Journal of Pineal Research, ISSN 0742-3098, 04/2015, Volume 58, Issue 3, pp. 343 - 351
Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for... 
dioxygenase | melatonin catabolism | prohexadione‐Ca | 2‐hydroxymelatonin | 2‐oxoglutarate‐dependent dioxygenase | 2-hydroxymelatonin | prohexadione-Ca | 2-oxoglutarate-dependent dioxygenase | TRYPTOPHAN | N-ACETYLSEROTONIN METHYLTRANSFERASE | DEFENSE RESPONSES | PHYSIOLOGY | SEED-GERMINATION | NEUROSCIENCES | EDIBLE PLANTS | ENDOCRINOLOGY & METABOLISM | SEROTONIN BIOSYNTHESIS | RESISTANCE | ARABIDOPSIS | TRYPTAMINE | ACETYLTRANSFERASE | Recombinant Proteins - metabolism | Recombinant Proteins - chemistry | Mixed Function Oxygenases - metabolism | Mixed Function Oxygenases - antagonists & inhibitors | Mixed Function Oxygenases - chemistry | Recombinant Proteins - genetics | Oryza - enzymology | Melatonin - analogs & derivatives | Oryza - genetics | Escherichia coli - genetics | Cloning, Molecular - methods | Melatonin - metabolism | Mixed Function Oxygenases - genetics | Physiological aspects | Melatonin | Cloning
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10. Full Text Melatonin enhances lipid production in Monoraphidium sp. QLY-1 under nitrogen deficiency conditions via a multi-level mechanism
by Zhao, Yongteng and Zhao, Peng and Li, Dafei and Li, Tao and Xu, Jun-Wei and Ma, Huixian and Yu, Xuya
Bioresource Technology, ISSN 0960-8524, 07/2018, Volume 259, pp. 46 - 53
In this study, melatonin (MT) promoted lipid accumulation in sp. QLY-1 under nitrogen deficiency conditions. The lipid accumulation increased 1.22- and... 
Nitrogen deficiency | Melatonin | Microalgae | Signalling molecules | Lipid | Antioxidant systems | OLEAGINOUS MICROALGA | OXIDATIVE STRESS | DACTYLON (L). PERS | SCENEDESMUS QUADRICAUDA | BIOFUEL PRODUCTION | ENERGY & FUELS | AGRICULTURAL ENGINEERING | ANALYSES REVEAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STARVED CONDITION | ABSCISIC-ACID | NANNOCHLOROPSIS-OCEANICA | CHLORELLA-SOROKINIANA | Abscisic acid | Gene expression
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