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Cellular Signalling, ISSN 0898-6568, 11/2019, Volume 63, pp. 109366 - 109366
Maternal embryonic leucine-zipper kinase (MELK) overexpression impacts survival and proliferation of multiple cancer types, most notably glioblastomas and... 
Maternal embryonic leucine-zipper kinase (MELK) | Arrestin | Protein-protein interactions | Cell fate signaling | Index Medicus
Journal Article
Endocrinology, ISSN 0013-7227, 07/2018, Volume 159, Issue 7, pp. 2532 - 2544
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 03/2018, Volume 16, Issue 9, pp. 1489 - 1495
Journal Article
Molecular Cancer, ISSN 1476-4598, 05/2014, Volume 13, Issue 1, pp. 100 - 100
Background: Elevated MELK expression is featured in multiple tumors and correlated with tumorigenesis and tumor development. This study is aimed to investigate... 
FAK | MELK | Tumor migration | Gastric cancer | Paxillin | Tumor invasion | MIGRATION | CELL-CYCLE REGULATION | METASTASIS | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | ONCOLOGY | TUMOR STEM-CELLS | FOCAL ADHESION KINASE | Paxillin - metabolism | Cell Cycle - genetics | Focal Adhesion Kinase 1 - genetics | RNA, Small Interfering - genetics | Paxillin - genetics | Phosphorylation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Stomach Neoplasms - metabolism | Male | Stomach Neoplasms - pathology | Actin Cytoskeleton - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Focal Adhesion Kinase 1 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Stomach Neoplasms - genetics | Cell Survival - drug effects | Signal Transduction | Neoplasm Invasiveness | Protein-Serine-Threonine Kinases - genetics | Stomach Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Cell Cycle - drug effects | RNA, Small Interfering - metabolism | Animal experimentation | Development and progression | Metastasis | Muscle proteins | Statistical analysis | Science | Breast cancer | Kinases | Cancer therapies | Stomach cancer | Cell adhesion & migration | Proteins | Rodents | Surgery | Medical prognosis | Stem cells | Cytoskeleton | Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2008, Volume 122, Issue 4, pp. 807 - 815
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 08/2019, Volume 671, pp. 1 - 7
Maternal Embryonic Leucine Zipper Kinase (MELK) is overexpressed in various tumors which has been convincingly linked to tumor cell survival. As such, MELK... 
Dorsomorphin | MELK | Structure | Kinase | Cancer | DNA binding proteins | Vascular endothelial growth factor | Crystals | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 5, pp. 1 - 15
Maternal embryonic leucine zipper kinase (MELK) is upregulated in a variety of human tumors, and is considered an attractive molecular target for cancer... 
MELK | Prognosis | Metastasis | PDX | Gastric cancer | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Humans | Middle Aged | Cell Proliferation - physiology | Male | Stomach Neoplasms - pathology | Leucine Zippers - genetics | Pregnancy | Neoplasm Metastasis | Cell Cycle - physiology | Female | Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 03/2016, Volume 7, Issue 12, pp. 13621 - 13633
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 4711 - 4723
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2015, Volume 6, Issue 1, pp. 25 - 30
Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 mu M) fragment hit was identified,... 
structure-based optimization | fragment-based drug design | Maternal embryonic leucine zipper kinase | TARGET | CELLS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MELK | GROWTH |