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Molecular cancer, ISSN 1476-4598, 2014, Volume 13, Issue 1, pp. 100 - 100
Journal Article
Oncology letters, ISSN 1792-1074, 06/2017, Volume 13, Issue 6, pp. 4794 - 4798
Maternal embryonic leucine zipper kinase (MELK) performs an important role in self-renewal and proliferation of progenitor cells or tumor stem cells, and is expressed in aggressive cancers, contributing to tumorigenesis... 
Epithelial-mesenchymal transition | Smad | Transforming growth factor-β | A549 | Maternal embryonic leucine zipper kinase | STEM-CELLS | PHOSPHORYLATION | PROLIFERATION | CANCER | maternal embryonic leucine zipper kinase | FAMILY | MEMBER | transforming growth factor-beta | MELK | ONCOLOGY | epithelial-mesenchymal transition
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 01/2015, Volume 6, Issue 1, pp. 25 - 30
Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM... 
structure-based optimization | fragment-based drug design | Maternal embryonic leucine zipper kinase | TARGET | CELLS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MELK | GROWTH | PROLIFERATION | EXPRESSION
Journal Article
Experimental cell research, ISSN 0014-4827, 2010, Volume 316, Issue 13, pp. 2166 - 2173
Journal Article
Cellular signalling, ISSN 0898-6568, 2019, Volume 63, p. 109366
Maternal embryonic leucine-zipper kinase (MELK) overexpression impacts survival and proliferation of multiple cancer types, most notably glioblastomas and breast cancer... 
Maternal embryonic leucine-zipper kinase (MELK) | Arrestin | Protein-protein interactions | Cell fate signaling | LOCALIZATION | ACTIVATION | BETA-ARRESTIN-2 | RECEPTOR | BETA-ARRESTIN | ENDOCYTOSIS | CELL BIOLOGY | UBIQUITINATION | MELK | SCAFFOLDS | BINDING
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 2014, Volume 13, Issue 6, pp. 1393 - 1398
Journal Article
Journal Article
Endocrinology (Philadelphia), ISSN 1945-7170, 2018, Volume 159, Issue 7, pp. 2532 - 2544
...%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified maternal embryonic leucine zipper kinase (MELK... 
GROWTH-FACTOR RECEPTOR | CELLS | ACTIVATED PROTEIN-KINASE | MELK | TRANSCRIPT ABUNDANCE | THERAPEUTIC TARGET | ENDOCRINOLOGY & METABOLISM | GENOMIC CHARACTERIZATION | TUMORS | EXPRESSION | CANCER | Cell proliferation | Biotechnology | Cell survival | Colonies | Cell division | Caspase | Leucine | Dosage | Kinases | Gene expression | Caspase-3 | Survival | Embryos | Leucine zipper proteins | Cell growth | Hypoxia | Inhibition | Tumors | Cancer | Apoptosis
Journal Article
Haematologica (Roma), ISSN 1592-8721, 2018, Volume 103, Issue 8, pp. 1359 - 1368
Multiple myeloma bone disease is characterized by an uncoupling of bone remodeling in the multiple myeloma microenvironment, resulting in the development of... 
CANCER-CELLS | IN-VITRO | OSTEOBLAST DIFFERENTIATION | MELK | MANAGEMENT | PHOSPHORYLATION | GLIOMA STEM-CELLS | PROLIFERATION | SUPPRESSES | HEMATOLOGY | EZH2
Journal Article
Haematologica (Roma), ISSN 1592-8721, 2018, Volume 103, Issue 2, pp. 325 - 335
... to overcome the poor prognosis of these patients. We therefore examined maternal embryonic leucine zipper kinase (MELK... 
MULTIPLE-MYELOMA | THERAPEUTIC TARGET | DISEASE | GROWTH | GLIOMA STEM-CELLS | MELK INHIBITOR | HEMATOLOGY | ADAPTED TREATMENT | CANCER | EXPRESSION | PIVOTAL ROLE
Journal Article
Oncogene, ISSN 0950-9232, 10/2018, Volume 37, Issue 41, pp. 5520 - 5533
...), which represents an unmet clinical need with few therapeutic options. Maternal embryonic leucine zipper kinase (MELK... 
CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | JNK/MITOCHONDRIAL PATHWAY | LARGE GENE LISTS | CELL BIOLOGY | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | MELK EXPRESSION | IBRUTINIB RESISTANCE | ONCOLOGY | GENETICS & HEREDITY | GLIOMA STEM-CELLS | EXPRESSION SIGNATURE | DISEASE PROGRESSION | Apoptosis - drug effects | Humans | Middle Aged | Cell Proliferation - physiology | Male | Cell Movement - physiology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Cell Movement - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Aged, 80 and over | Adult | Female | Aged | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Naphthyridines - pharmacology | Molecular targeted therapy | Chronic lymphocytic leukemia | Care and treatment | Innovations | Genetic aspects | Drug therapy | Phosphotransferases | Health aspects | Oncogenes | Cell proliferation | Phosphorylation | p53 Protein | Leukemia | AKT protein | Kinases | Cyclin B1 | Signal transduction | Cell growth | Antitumor agents | Clonal deletion | Chronic lymphatic leukemia | Cell survival | Therapeutic applications | Myeloid leukemia | Extracellular signal-regulated kinase | Breast cancer | Lymphatic leukemia | Gene expression | Chemotaxis | Embryos | Patients | Leucine zipper proteins | Overexpression | Fludarabine | Medical prognosis | Stem cells | Acute myeloid leukemia | Apoptosis
Journal Article