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Cancer Research, ISSN 0008-5472, 10/2006, Volume 66, Issue 20, pp. 9870 - 9877
Hypoxia-inducible factor 1 (HIF1) is up-regulated in most malignant tumors usually via interruption of ubiquitination and proteasomal degradation of its... 
GENE | ONCOLOGY | TUMOR SUPPRESSION | MEMBRANE-PROTEIN 1 | GROWTH | ABSENTIA | BETA-CATENIN | HIF-ALPHA | EXPRESSION | EPSTEIN-BARR-VIRUS | HUMAN HOMOLOG
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 15, pp. 6814 - 6829
Polyamine derivatives have a promising prospect in dealing with disseminated tumor cells, a major obstacle in cancer therapy. To develop a bifunctional... 
SIDE-CHAINS | DESIGN | CHEMISTRY, MEDICINAL | F14512 | BIOLOGICAL EVALUATION | VECTORIZED ANTICANCER DRUG | OPTIMIZATION | MEDIATED APOPTOSIS | INHIBITORS | AUTOPHAGY | CANCER
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 740 - 747
BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy in mammalian cells.... 
BECN1 | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 β | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | BCL2L1/Bcl | PtdIns3K | BECN1, Beclin 1, autophagy related | BafA1, bafilomycin A | BECN1P1/BECN2, Beclin 1, autophagy related, pseudogene 1 | EM, electron microscopy | UVRAG, UV radiation resistance associated | MAP1LC3-II/LC3-II, proteolytically processed and lipid-modified microtubule-associated protein 1 light chain 3 | LC3 | ZFYVE1/DFCP1, zinc finger, FYVE domain containing 1 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | TALEN, transcription activator-like effector nuclease | GFP, green fluorescent protein | autophagy | SQSTM1/p62, sequestosome 1 | xL, BCL2-like 1 | PtdIns3K, phosphatidylinositol 3-kinase | - | PIK3R4/VPS15, phosphoinositide-3-kinase, regulatory subunit 4 | 1 | TUBB, tubulin, β class I | KO, knockout | MAP1LC3-I/LC3-I, soluble, proteolytically processed microtubule-associated protein 1 light chain 3 | ATG, autophagy related | autophagosome | PIK3C3/VPS34, phosphatidylinositol 3-kinase, catalytic subunit type 3 | Autophagosome | Autophagy | CANCER-CELLS | ATG PROTEINS | COMPLEX | PHOSPHATIDYLINOSITOL 3-KINASE | BECLIN 1-INDEPENDENT AUTOPHAGY | MACROAUTOPHAGY | ARSENIC TRIOXIDE | CELL BIOLOGY | 1 PHOSPHORYLATION | PATHWAY | RUBICON | Beclin-1 | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Molecular Sequence Data | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - deficiency | Lipids - chemistry | Apoptosis Regulatory Proteins - deficiency | Base Sequence | Phagosomes - ultrastructure | Membrane Proteins - metabolism | HeLa Cells
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 1937 - 1952
Lipopolysaccharide (LPS)-induced activation of TLR4 (toll-like receptor 4) is followed by a subsequent overwhelming inflammatory response, a hallmark of the... 
ACTB, actin, beta | MYD88, myeloid differentiation primary response 88 | PELI3 | CHX, cycloheximide | BECN1, Beclin 1, autophagy related | TICAM1, toll-like receptor adaptor molecule 1 | LPS | RIPK1, receptor (TNFRSF)-interacting serine-threonine kinase 1 | TUBB, tubulin, beta class I | PRRs, pattern recognition receptors | UBB, ubiquitin B | IRAKs, interleukin-1 receptor-associated kinases | HBSS, Hank's balanced salt solution | ATG7, autophagy-related 7 | MAP1LC3B, microtubule-associated protein 1 light chain 3 beta | TLRs, toll-like receptors | Baf A1, bafilomycin A | WT, wildtype | autophagy | TNF, tumor necrosis factor | MAPK14, mitogen-activated protein kinase 14 | NFKB, nuclear factor of kappa light polypeptide gene enhancer in B-cells | MAPK1/3, mitogen-activated protein kinase 1/3 | Epoxo, epoxomycin | TRAF6, TNF receptor-associated factor 6, E3 ubiquitin protein ligase | IL1B, interleukin 1, beta | MTOR, mechanistic target of rapamycin (serine/threonine kinase) | TABs, TGF-beta activated kinase 1/MAP3K7 binding protein 1/2/3 | Wortm, wortmannin | 1 | PELI3, pellino E3 ubiquitin protein ligase family member 3 | MAPK8/9, mitogen-activated protein kinase 8/9 | SQSTM1, sequestosome 1 | NFE2L2, nuclear factor, erythroid 2-like 2 | NLRP3, NLR family, pyrin domain containing 3 | LAMP2, lysosomal-associated membrane protein 2 | LPS, lipopolysaccharide | MAP3K14, mitogen-activated protein kinase kinase kinase 14 | MΦ, macrophages | Rapa, rapamycin | SQSTM1 | TBK1, TANK-binding kinase 1 | Torin2 | MAP3K7, mitogen-activated protein kinase kinase kinase 7 | Autophagy | TOLL-LIKE-RECEPTORS | ACTIVATION | BECLIN 1 | RECOGNITION | SELECTIVE AUTOPHAGY | CELL BIOLOGY | UBIQUITINATION | IL-1-BETA PRODUCTION | INFLAMMASOME | SCAFFOLD PROTEINS | INNATE IMMUNITY | Cell Line | Cytokines - metabolism | Signal Transduction | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Lipopolysaccharides - metabolism | Inflammation | Immunity, Innate | RNA, Messenger - metabolism | Toll-Like Receptor 4 - metabolism | Point Mutation | Macrophages - metabolism | Animals | Interleukin-1beta - metabolism | Sepsis - metabolism | Mice | Naphthyridines - metabolism | RNA, Small Interfering - metabolism
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2005, Volume 25, Issue 4, pp. 854 - 860
Journal Article
Autophagy, ISSN 1554-8627, 01/2015, Volume 11, Issue 1, pp. 88 - 99
Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation of microtubule-associated protein 1 light chain 3 (LC3) onto... 
RB1CC1/FIP200, RB1-inducible coiled-coil 1 | PIK3C3/VPS34, phosphatidylinositol 3-kinase | FYCO1, FYVE and coiled-coil domain containing 1 | V-ATPase, vacuolar-type H | ConA, concanamycin A | LAMP1, lysosomal-associated membrane protein 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | ATG, autophagy-related | chloroquine | Helicobacter pylori | ULK1/2, unc-51 like autophagy activating kinase 1/2 | entosis | LC3 | TLR, toll-like receptor | phagocytosis | LAP, LC3-associated phagocytosis | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | autophagy | V-ATPase | SQSTM1/p62, sequestosome 1 | ATPase | PtdIns3K, phosphatidylinositol 3-kinase | + | CQ, chloroquine | TEM, transmission electron microscopy | 1 | PtdIns3P, phosphatidylinositol 3-phosphate | VacA, vacuolating toxin A | Baf, bafilomycin A | LAP | catalytic subunit type 3 | CALCOCO2/NDP52, calcium binding and coiled-coil domain 2 | lysosome | Entosis | Chloroquine | Lysosome | Autophagy | Phagocytosis | REACTIVE OXYGEN PRODUCTION | RAT HEPATOCYTES | VACUOLATING CYTOTOXIN | MEMBRANE | TOXIN | MACROPHAGES | CHAIN 3 PROTEIN | CELL BIOLOGY | NONCANONICAL AUTOPHAGY | EPITHELIAL-CELLS | HELICOBACTER-PYLORI | Lysosomes - drug effects | Water | Cell Line | Phagocytosis - drug effects | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Monensin - pharmacology | Osmosis - drug effects | Vacuolar Proton-Translocating ATPases - metabolism | Autophagy - drug effects | Endosomes - metabolism | Lysosomes - ultrastructure | Chloroquine - pharmacology | Lipids - chemistry | Animals | Lysosomes - metabolism | Endosomes - drug effects | Endosomes - ultrastructure | Entosis - drug effects | Bacterial Proteins - metabolism | Mice
Journal Article