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Neuron, ISSN 0896-6273, 09/2013, Volume 79, Issue 6, pp. 1169 - 1182
The gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1... 
MAMMALIAN TARGET | LOCAL PROTEIN-SYNTHESIS | AUTISM | FMRP | MOUSE MODEL | FRAGILE-X-SYNDROME | MECHANISMS | RAC1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | CRITICAL REGION | Humans | Male | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Mental Disorders - genetics | Brain-Derived Neurotrophic Factor - pharmacology | Neurons - ultrastructure | Time Factors | Chromatography, Liquid | Nerve Tissue Proteins - ultrastructure | Enzyme Inhibitors - pharmacology | Mice, Transgenic | Pyrimidines - pharmacology | Synaptosomes - ultrastructure | Analysis of Variance | Indole Alkaloids - pharmacology | Protein Biosynthesis - drug effects | Mice | Carbazoles - pharmacology | Adaptor Proteins, Signal Transducing - chemistry | Synaptosomes - drug effects | Meta-Analysis as Topic | Immunoprecipitation | Age Factors | Synaptosomes - metabolism | Cerebral Cortex - cytology | Microscopy, Immunoelectron | DNA-Binding Proteins - metabolism | Tandem Mass Spectrometry | Nerve Tissue Proteins - chemistry | Transfection | Dendritic Spines - drug effects | Protein Biosynthesis - genetics | Neurons - drug effects | Aminoquinolines - pharmacology | Green Fluorescent Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | Fragile X Mental Retardation Protein - ultrastructure | Dendritic Spines - genetics | Fragile X Mental Retardation Protein - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Nervous system diseases | Neurosciences | Neurons | Oncology, Experimental | Genes | Polymerization | Schizophrenia | Protein biosynthesis | Research | Genetic translation | Messenger RNA | Actin | Cancer | Proteins | Brain-derived neurotrophic factor | Protein synthesis | Crystal structure
Journal Article
Developmental Neurobiology, ISSN 1932-8451, 01/2019, Volume 79, Issue 1, pp. 85 - 95
Since the first observation that described a patient with a mutation in IL1RAPL1 gene associated with intellectual disability in 1999, the function of IL1RAPL1... 
dendrites | IL‐1β | excitatory synapses | hippocampus | postsynapse | IL-1β | MENTAL-RETARDATION | FRAGILE-X | IL-1 beta | MECHANISMS | DEVELOPMENTAL BIOLOGY | NEUROSCIENCES | CHROMOSOME | TYROSINE-PHOSPHATASE-RECEPTOR | GENE | PTP-DELTA | RHO GTPASES | LAR | Proteins | Autism | Clonal deletion | Intellectual disabilities | Morphology | Interleukin | Interleukin 1 | Deletion | Mutation | Dendritic structure
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 299 - 15
The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin... 
B-CELLS | CONSTITUTIVE-DECAY ELEMENT | AUTOIMMUNITY | MULTIDISCIPLINARY SCIENCES | TFH-CELL-DIFFERENTIATION | INDUCIBLE COSTIMULATOR | STEM-LOOP | MENTAL-RETARDATION PROTEIN | STRESS GRANULE | HELPER T-CELLS | DEPENDENT DECAY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Receptors, OX40 - genetics | Humans | Receptors, OX40 - immunology | CD4-Positive T-Lymphocytes - immunology | Ubiquitin-Protein Ligases - immunology | HEK293 Cells | Inducible T-Cell Co-Stimulator Protein - genetics | Inducible T-Cell Co-Stimulator Protein - antagonists & inhibitors | Nuclear Proteins - genetics | Nucleic Acid Conformation | Binding Sites | Inducible T-Cell Co-Stimulator Protein - immunology | Inverted Repeat Sequences | RNA-Binding Proteins - antagonists & inhibitors | Amino Acid Sequence | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | RNA-Binding Proteins - immunology | Gene Expression Regulation | Repressor Proteins - genetics | Recombinant Proteins - genetics | Nuclear Proteins - immunology | RNA Stability | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Recombinant Proteins - immunology | Nuclear Proteins - antagonists & inhibitors | Repressor Proteins - immunology | Protein Binding | Mice | HeLa Cells | Primary Cell Culture | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | Receptors, OX40 - antagonists & inhibitors | Post-transcription | Target recognition | Cell survival | RNA-mediated interference | mRNA turnover | Ribonucleic acid--RNA | Cofactors | Proteins | Gene silencing | RNA-binding protein | 3' Untranslated regions | Tumor necrosis factor | ICOS protein | Decay
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2018, Volume 20, Issue 9, pp. 1023 - 1023
Endocytosis mediates the cellular uptake of micronutrients and the turnover of plasma membrane proteins. Clathrin-mediated endocytosis is the major uptake... 
CDC42 | DOMAIN | BAR | LINKED MENTAL-RETARDATION | CLATHRIN-INDEPENDENT ENDOCYTOSIS | EGF-RECEPTOR | PATHWAY | LEADING-EDGE | PROTEIN GRAF1 | ACTIN CYTOSKELETON | CELL BIOLOGY | Phosphatidylinositol Phosphates - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | cdc42 GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | GTPase-Activating Proteins - metabolism | Endocytosis | Time Factors | HEK293 Cells | Minor Histocompatibility Antigens - genetics | Cell Membrane - metabolism | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Signal Transduction | Membrane Proteins - genetics | Rats | Carrier Proteins - genetics | Minor Histocompatibility Antigens - metabolism | Animals | Carrier Proteins - metabolism | cdc42 GTP-Binding Protein - genetics | Protein Binding | GTPase-Activating Proteins - genetics | Clathrin | Cell membranes | Research | Analysis | Cdc42 protein | GTP | Deactivation | Stimulation | Activation | Membrane proteins | Proteins | Phosphatidylinositol | Micronutrients | Receptors | Inositol polyphosphate 5-phosphatase | Dismantling | Guanosinetriphosphatase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2008, Volume 283, Issue 27, pp. 18478 - 18482
Journal Article
The FEBS Journal, ISSN 1742-464X, 06/2018, Volume 285, Issue 11, pp. 2091 - 2103
Fourteen inhibitors of the Tudor domain‐containing protein 3 (TDRD3) Tudor domain were identified using fragment screening. The crystal complex structure of... 
fragment‐based screening | structural plasticity | arginine methylation | Tudor domain‐containing protein 3 | protein–ligand complex structure | Tudor domain-containing protein 3 | fragment-based screening | RECRUITMENT | PROTEIN | RECOGNITION | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMALL-MOLECULE LIGANDS | IDENTIFICATION | INHIBITION | DYNAMICS | protein-ligand complex structure | STRESS GRANULES | Cell Proliferation - genetics | Transcriptional Activation - genetics | Tumor Suppressor p53-Binding Protein 1 - chemistry | Tumor Suppressor p53-Binding Protein 1 - genetics | Humans | Crystallography, X-Ray | Amino Acid Sequence - genetics | Nuclear Proteins - chemistry | Tudor Domain | Proteins - genetics | Small Molecule Libraries - chemistry | Hydrogen Bonding | Nuclear Magnetic Resonance, Biomolecular | Protein Conformation | Proteins - chemistry | Nuclear Proteins - genetics | Arginine | Hydrogen | Crystals | Medical screening | Tumor proteins | Methylation | Structure | Mental illness | Investigations | Protein binding | Cell proliferation | Nuclear magnetic resonance--NMR | p53 Protein | SMN protein | Fluorescence | Kinases | DNA-directed RNA polymerase | Mental retardation | Proteins | Hydrogen bonds | Transcription activation | Plasticity | Nuclease | Crystal structure | Fluorescence polarization | Cell survival | Titration calorimetry | Ribonucleic acid--RNA | Molecular chains | Substrates | Polymerase | Screening | Calorimetry | Titration | Plastic properties | Fragile X syndrome | RNA polymerase II | Cytoplasm | Cancer | FMR1 protein | Warheads
Journal Article
Neuron, ISSN 0896-6273, 2008, Volume 59, Issue 1, pp. 70 - 83
Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is... 
PROTEINS | MOLNEURO | SIGNALING | MESSENGER-RNAS | RIBOSOMAL-PROTEINS | IMMEDIATE-EARLY GENE | GLUTAMATE RECEPTORS | POSTSYNAPTIC SITES | AMPA RECEPTORS | FACTOR-II | LONG-TERM DEPRESSION | MOUSE MODEL | SYNAPTIC PLASTICITY | NEUROSCIENCES | Excitatory Postsynaptic Potentials - radiation effects | Protein Biosynthesis - physiology | Fragile X Mental Retardation Protein - physiology | Male | Protein Transport - physiology | Protein Transport - drug effects | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Long-Term Potentiation - physiology | Cytoskeletal Proteins - metabolism | Protein Biosynthesis - radiation effects | Protein Synthesis Inhibitors - pharmacology | Electric Stimulation - methods | Animals, Newborn | Receptors, AMPA - physiology | Cells, Cultured | Hippocampus - cytology | Cycloheximide - pharmacology | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Peptide Elongation Factor 2 - physiology | Models, Biological | Gene Expression Regulation - radiation effects | Protein Biosynthesis - drug effects | Fragile X Mental Retardation Protein - genetics | Mice | In Vitro Techniques | Dose-Response Relationship, Radiation | Proteins | Studies | Cell culture | Kinases | Protein synthesis | Neurons | Index Medicus
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2011, Volume 20, Issue 8, pp. 1560 - 1573
Mental retardation in Down syndrome (DS) appears to be related to severe neurogenesis impairment during critical phases of brain development. Recent lines of... 
TS65DN MOUSE MODEL | TARGET GENES | METHYLATION | SONIC HEDGEHOG | RESTORES NEUROGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | CELL-PROLIFERATION | MICE | FETUSES | INTRACELLULAR DOMAIN | Up-Regulation | Hedgehog Proteins - pharmacology | Lateral Ventricles - pathology | Cell Proliferation | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Male | RNA Interference | Smoothened Receptor | Acetylation | Patched Receptors | Hippocampus - embryology | Repressor Proteins - genetics | Thiophenes - pharmacology | Hippocampus - pathology | Polycomb Repressive Complex 1 | Mice | Receptors, G-Protein-Coupled - genetics | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Cell Cycle - genetics | Down Syndrome - metabolism | Lateral Ventricles - metabolism | Receptors, G-Protein-Coupled - agonists | Lateral Ventricles - embryology | DNA Methylation | Hedgehog Proteins - genetics | Cyclohexylamines - pharmacology | Amyloid beta-Protein Precursor - metabolism | Neurons - physiology | Veratrum Alkaloids - pharmacology | Female | Receptors, Cell Surface - biosynthesis | Nuclear Proteins - genetics | Protein Structure, Tertiary | Promoter Regions, Genetic | Mice, Inbred C57BL | Neural Stem Cells - physiology | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Down Syndrome - embryology | Hippocampus - metabolism | Animals | Down Syndrome - genetics | Forkhead Box Protein M1 | Cell proliferation | Cerebellum | Brain | subventricular zone | Animal models | Cell division | Data processing | Mental retardation | Neurogenesis | Amyloid precursor protein | Promoters | Membrane proteins | Molecular modelling | Down's syndrome | Hedgehog protein | Neural stem cells | Alzheimer's disease | Mitogens | Hippocampus
Journal Article