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1. Full Text Spliceosome structure and function
by Will, Cindy L and Lührmann, Reinhard
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 07/2011, Volume 3, Issue 7, pp. 1 - 2
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and numerous proteins. Intricate... 
GROUP-II INTRON | SMALL NUCLEAR-RNA | CRYSTAL-STRUCTURE | DEXD/H-BOX ATPASE | ELECTRON-MICROSCOPY | SPLICING SIGNAL INTERACTIONS | TRI-SNRNP | U2 SNRNA | CATALYTIC STEPS | PRE-MESSENGER-RNA | CELL BIOLOGY | Protein Structure, Tertiary | Spliceosomes - chemistry | Catalytic Domain | Humans | Spliceosomes - physiology | Ribonucleoproteins - physiology | Models, Molecular | Crystallography, X-Ray | Spliceosomes - ultrastructure | RNA Splicing - physiology | Ribonucleoproteins, Small Nuclear - physiology | Nuclear Magnetic Resonance, Biomolecular | RNA Precursors - metabolism | Models, Genetic | Protein Processing, Post-Translational | Ribonucleoproteins, Small Nuclear - chemistry | Ribonucleoproteins - chemistry | Nucleic Acid Conformation | Concepts | 052
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2. Full Text Structure and function of the 5′3′ exoribonuclease Rat1 and its activating partner Rai1
by Xiang, Song and Cooper-Morgan, Amalene and Jiao, Xinfu and Kiledjian, Megerditch and Manley, James L and Tong, Liang
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7239, pp. 784 - 788
The 5'-> 3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA... 
RNA-POLYMERASE-II | MACROMOLECULAR STRUCTURES | PROTEIN | TURNOVER | NUCLEAR | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | EXONUCLEASE | TRANSCRIPTION TERMINATION | SACCHAROMYCES-CEREVISIAE | PIN DOMAINS | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Exoribonucleases - genetics | Schizosaccharomyces pombe Proteins - genetics | Schizosaccharomyces - chemistry | Exoribonucleases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Schizosaccharomyces - genetics | Animals | Schizosaccharomyces pombe Proteins - metabolism | Protein Binding | Schizosaccharomyces - enzymology | Mice | Mutation | Exoribonucleases - metabolism | Physiological aspects | Ribonuclease | Research | Structure | Crystals | Proteins | Enzymes | Bacteria | E coli | Crystal structure | Index Medicus | pol II termination | RNAi | RNA pyrophosphohydrolase | mRNA processing | torpedo model | nonsense mediated decay | protein complex | RNA metabolism
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3. Full Text XRN 5′→3′ exoribonucleases: Structure, mechanisms and functions
by Nagarajan, Vinay K and Jones, Christopher I and Newbury, Sarah F and Green, Pamela J
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 06/2013, Volume 1829, Issue 6-7, pp. 590 - 603
The XRN family of 5′ → 3′ exoribonucleases is critical for ensuring the fidelity of cellular RNA turnover in eukaryotes. Highly conserved across species, the... 
RNA decay | Exoribonuclease | XRN1/PACMAN | Transcriptional surveillance | Small RNA | XRN2/RAT1 | ETHYLENE SIGNAL-TRANSDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXONUCLEASE XRN2 | QUALITY-CONTROL | RIBOSOMAL-RNA | SACCHAROMYCES-CEREVISIAE | ENDONUCLEOLYTIC CLEAVAGE | DHP1(+) GENE | BIOPHYSICS | SMALL NUCLEOLAR RNAS | MESSENGER-RNA DECAY | PROMOTES TRANSCRIPTION TERMINATION | Microtubule-Associated Proteins - chemistry | Exoribonucleases - genetics | Microtubule-Associated Proteins - genetics | Humans | RNA, Messenger - genetics | Exoribonucleases - chemistry | RNA Stability - genetics | Animals | Cell Nucleus - genetics | Eukaryota | Cytoplasm - genetics | Drosophila - growth & development | Drosophila Proteins - genetics | Mutation | Drosophila - genetics | Physiological aspects | Genetic engineering | Genetic transcription | Ribonuclease | RNA | Analysis
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4. Full Text The Structure of the Eukaryotic Ribosome at 3.0 Ã… Resolution
by Adam Ben-Shem and Nicolas Garreau de Loubresse and Sergey Melnikov and Lasse Jenner and Gulnara Yusupova and Marat Yusupov
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6062, pp. 1524 - 1529
Ribosomes translate genetic information encoded by messenger RNA into proteins. Many aspects of translation and its regulation are specific to eukaryotes,... 
Proteins | Yeasts | Messenger RNA | RNA | RESEARCH ARTICLES | Ribosomes | Bacteria | Gene expression regulation | Eukaryotic cells | Tunnels | Crystal structure | Cryoelectron Microscopy | DNA-Binding Proteins - ultrastructure | RNA, Ribosomal - ultrastructure | Saccharomyces cerevisiae Proteins - ultrastructure | RNA, Fungal - ultrastructure | Ribosomes - ultrastructure | Saccharomyces cerevisiae - genetics | Models, Molecular | Crystallography, X-Ray | Saccharomyces cerevisiae - ultrastructure | Physiological aspects | Genetic aspects | Research | Brewer's yeast | Eukaryotes | Yeast | RNA-protein interactions
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5. Full Text A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility
by Agami, Reuven and van Kouwenhove, Marieke and Zwart, Wilbert and Elkon, Ran and Oude Vrielink, Joachim A. F and Kedde, Martijn
Nature Cell Biology, ISSN 1465-7392, 10/2010, Volume 12, Issue 10, pp. 1014 - 1020
Key regulators of 3′ untranslated regions (3′ UTRs) are microRNAs and RNA-binding proteins (RBPs). The p27 tumour suppressor is highly expressed in quiescent... 
MESSENGER-RNA | GENE | LET-7 MICRORNA | TUMOR-SUPPRESSOR | PROLIFERATION | CANCER | STRESS GRANULES | P27(KIP1) | REVEALS | CELL BIOLOGY | RNA-Binding Proteins - genetics | Humans | Cells, Cultured | 3' Untranslated Regions - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Base Sequence | Cell Cycle - physiology | MicroRNAs - genetics | Nucleic Acid Conformation | RNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | RNA - metabolism | Caenorhabditis elegans | MicroRNA | Analysis | Physiological aspects | Genetic aspects | Gene expression | Structure
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6. Full Text The 3.8 Ã… structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
by Wan, Ruixue and Yan, Chuangye and Bai, Rui and Wang, Lin and Huang, Min and Wong, Catherine C. L and Shi, Yigong
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6272, pp. 466 - 475
Splicing of precursor messenger RNA is accomplished by a dynamic megacomplex known as the spliceosome. Assembly of a functional spliceosome requires a... 
RNA Precursors - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Spliceosomes - chemistry | RNA, Small Nuclear - ultrastructure | Spliceosomes - ultrastructure | Ribonucleoprotein, U4-U6 Small Nuclear - ultrastructure | Cryoelectron Microscopy | Saccharomyces cerevisiae - metabolism | RNA Splicing | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | Ribonucleoprotein, U5 Small Nuclear - ultrastructure | Protein Conformation | RNA, Messenger - chemistry | RNA, Small Nuclear - chemistry | Catalysis | Nucleic Acid Conformation | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Chemical properties | Catalytic RNA | Structure | Observations | RNA polymerases | Molecular structure | Molecular biology | Ribonucleic acid--RNA
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7. Full Text Crystal structure of the ribosome at 5.5 Ã… resolution
by Yusupov, M.M and Yusupova, G.Zh and Baucom, A and Lieberman, K and Earnest, T.N and Cate, J.H.D and Noller, H.F
Science, ISSN 0036-8075, 05/2001, Volume 292, Issue 5518, pp. 883 - 896
We describe the crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom... 
Ribosomal Proteins - chemistry | Protein Biosynthesis | Bacterial Proteins - chemistry | Molecular Sequence Data | RNA, Transfer, Amino Acid-Specific - metabolism | Ribosomes - metabolism | Crystallography, X-Ray | Thermus thermophilus - ultrastructure | RNA, Messenger - metabolism | Ribosomal Proteins - metabolism | Base Sequence | Nucleic Acid Conformation | RNA, Transfer - chemistry | Anticodon | Binding Sites | RNA, Bacterial - metabolism | Thermus thermophilus - chemistry | RNA, Transfer - metabolism | RNA, Ribosomal - chemistry | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | RNA, Transfer, Amino Acid-Specific - chemistry | Ribosomes - ultrastructure | RNA, Bacterial - chemistry | Bacterial Proteins - metabolism | Protein Conformation | RNA, Messenger - chemistry | Messenger RNA | RNA | Peptides | Ribosomes | Research | Molecular biology | Statistics | Transfer RNA | Proteins | Cellular biology | Ribonucleic acid--RNA | Ribonucleic acid | Crystals
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8. Full Text Structure and function of the blood–brain barrier
by Abbott, N. Joan and Patabendige, Adjanie A.K and Dolman, Diana E.M and Yusof, Siti R and Begley, David J
Neurobiology of Disease, ISSN 0969-9961, 2009, Volume 37, Issue 1, pp. 13 - 25
Abstract Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers... 
Neurology | Blood–CSF-barrier | Pathology | Tight junctions | Transporters | Development | Receptor-mediated transcytosis | Adsorptive-mediated transcytosis | Drug delivery | Permeability | Drug discovery | Blood–brain barrier | Blood-brain barrier | Blood-CSF-barrier | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | AQUAPORIN-4 MESSENGER-RNA | NEUROSCIENCES | P-GLYCOPROTEIN | CEREBROSPINAL-FLUID PRODUCTION | MULTIPLE-SCLEROSIS | CENTRAL-NERVOUS-SYSTEM | CAPILLARY ENDOTHELIAL-CELLS | TIGHT JUNCTION PROTEINS | CANCER RESISTANCE PROTEIN | HUMAN GLIOBLASTOMA-MULTIFORME | Capillary Permeability - physiology | Brain - anatomy & histology | Humans | Brain - growth & development | Brain - physiology | Blood-Brain Barrier - anatomy & histology | Blood-Brain Barrier - pathology | Tight Junctions - physiology | Animals | Blood-Brain Barrier - physiology | Brain - pathology | Blood-Brain Barrier - growth & development | Models, Neurological | Drugs | Embryonic development | Drug delivery systems | Vehicles
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9. Full Text The structure of the human mitochondrial ribosome
by Amunts, A and Brown, A and Toots, J and Scheres, SHW and Ramakrishnan, V
SCIENCE, ISSN 0036-8075, 04/2015, Volume 348, Issue 6230, pp. 95 - 98
The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have... 
TRANSLOCATION | STRANDED-RNA | COMPLEX | MESSENGER-RNA | SEQUENCES | PROTEIN S1 | INITIATION | MULTIDISCIPLINARY SCIENCES | TRANSLATION | BINDING | SUBUNIT | Proteins | Physiological aspects | Mitochondrial DNA | Models | Structure | Ribosomes | Ribonucleic acid--RNA | Mitochondria | Mutations | Phosphorylation | Microscopy | Genes | Bacteria | Channels
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