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Journal Article
European Journal of Cancer, ISSN 0959-8049, 12/2017, Volume 87, pp. 131 - 139
Dysregulated MET signalling is implicated in oncogenesis. The safety and preliminary efficacy of a highly selective MET kinase inhibitor (SAR125844) was... 
Advanced solid tumours | Phase I | MET-amplified | NSCLC | Dose escalation | MET-inhibitor | ADENOCARCINOMA | ACQUIRED-RESISTANCE | RECEPTOR | TARGETING MET | SOMATIC MUTATIONS | CELL LUNG-CANCER | ONCOLOGY | C-MET | GROWTH | DOUBLE-BLIND | GENE COPY NUMBER | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | United States | Urea - pharmacokinetics | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Benzothiazoles - pharmacokinetics | Dose-Response Relationship, Drug | Time Factors | Antineoplastic Agents - adverse effects | Urea - analogs & derivatives | Biomarkers, Tumor - metabolism | Adult | Female | Antineoplastic Agents - pharmacokinetics | Biomarkers, Tumor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | Urea - administration & dosage | Lung Neoplasms - enzymology | Drug Administration Schedule | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Europe | Treatment Outcome | Proto-Oncogene Proteins c-met - genetics | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Gene Amplification | Signal Transduction - drug effects | Urea - adverse effects | Aged | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Benzothiazoles - adverse effects | Benzothiazoles - administration & dosage | Immunohistochemistry | Tyrosine | Medical research | Care and treatment | Medicine, Experimental | Lung cancer, Non-small cell | Tumors | Slopes | Phosphorylation | Inhibitor drugs | Intravenous administration | Toxicity | Copy number | Lung cancer | Fluorescence | Kinases | c-Met protein | Dyspnea | Pain | Safety engineering | Fluorescence in situ hybridization | Tumorigenesis | Safety | Constipation | Expansion | Protein-tyrosine kinase | Non-small cell lung carcinoma | Fatigue | Nausea | Pharmacology | Patients | Amplification | Inhibitors | Asthenia | Solid tumors | Respiration | Cancer | Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 2013, Volume 3, Issue 6, pp. 658 - 673
Journal Article
Oncogene, ISSN 0950-9232, 05/2016, Volume 35, Issue 21, pp. 2687 - 2697
Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell carcinoma (RCC). The purpose of this study was to understand the... 
ACTIVATION | METASTASIS | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL BIOLOGY | RECEPTOR TYROSINE KINASES | CABOZANTINIB XL184 | ONCOLOGY | C-MET | GROWTH | GENETICS & HEREDITY | EXPRESSION | PROGRESSION | Proto-Oncogene Proteins c-met - metabolism | Humans | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Sunitinib | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Carcinoma, Renal Cell - enzymology | Indoles - pharmacology | Carcinoma, Renal Cell - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Renal Cell - pathology | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Pyrroles - pharmacology | Animals | Receptor Protein-Tyrosine Kinases - genetics | Mice, Nude | Kidney Neoplasms - enzymology | Kidney Neoplasms - pathology | Cell Proliferation - drug effects | Mice | Kidney Neoplasms - drug therapy | Molecular targeted therapy | Genetic aspects | Carcinoma, Renal cell | Drug therapy | Drug resistance | Properties | Phosphotransferases | Methods | Cancer therapies | Kidney cancer | Metastasis | Index Medicus | Cabozantinib | Renal Cell Carcinoma | AXL | MET
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 45, pp. 72622 - 72633
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 24, pp. 10090 - 10100
Journal Article
by Linehan, W. Marston and Spellman, Paul T and Ricketts, Christopher J and Creighton, Chad J and Fei, Suzanne S and Davis, Caleb and Wheeler, David A and Murray, Bradley A and Schmidt, Laura and Vocke, Cathy D and Peto, Myron and Al Mamun, Abu Amar M and Shinbrot, Eve and Sethi, Anurag and Brooks, Samira and Rathmell, W. Kimryn and Brooks, Angela N and Hoadley, Katherine A and Robertson, A. Gordon and Brooks, Denise and Bowlby, Reanne and Sadeghi, Sara and Shen, Hui and Weisenberger, Daniel J and Bootwalla, Moiz and Baylin, Stephen B and Laird, Peter W and Cherniack, Andrew D and Saksena, Gordon and Haake, Scott and Li, Jun and Liang, Han and Lu, Yiling and Mills, Gordon B and Akbani, Rehan and Leiserson, Mark D.M and Raphael, Benjamin J and Anur, Pavana and Bottaro, Donald and Albiges, Laurence and Barnabas, Nandita and Choueiri, Toni K and Czerniak, Bogdan and Godwin, Andrew K and Hakimi, A. Ari and Ho, Thai H and Hsieh, James and Ittmann, Michael and Kim, William Y and Krishnan, Bhavani and Merino, Maria J and Shaw, Kenna R. Mills and Reuter, Victor E and Reznik, Ed and Shelley, Carl S and Shuch, Brian and Signoretti, Sabina and Srinivasan, Ramaprasad and Tamboli, Pheroze and Thomas, George and Tickoo, Satish and Burnett, Kenneth and Crain, Daniel and Gardner, Johanna and Lau, Kevin and Mallery, David and Morris, Scott and Paulauskis, Joseph D and Penny, Robert J and Shelton, Candace and Shelton, W. Troy and Sherman, Mark and Thompson, Eric and Yena, Peggy and Avedon, Melissa T and Bowen, Jay and Gastier-Foster, Julie M and Gerken, Mark and Leraas, Kristen M and Lichtenberg, Tara M and Ramirez, Nilsa C and Santos, Tracie and Wise, Lisa and Zmuda, Erik and Demchok, John A and Felau, Ina and Hutter, Carolyn M and Sheth, Margi and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean C and Zhang, Jiashan and Ayala, Brenda and Baboud, Julien and Chudamani, Sudha and Liu, Jia and Lolla, Laxmi and Naresh, Rashi and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England Journal of Medicine, ISSN 0028-4793, 01/2016, Volume 374, Issue 2, pp. 135 - 145
Journal Article
British Journal of Cancer, ISSN 0007-0920, 07/2017, Volume 117, Issue 3, pp. 347 - 352
Journal Article