X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (2233) 2233
life sciences & biomedicine (2028) 2028
humans (1836) 1836
oncology (1341) 1341
proto-oncogene proteins c-met - genetics (886) 886
female (822) 822
proto-oncogene proteins c-met - metabolism (814) 814
animals (754) 754
male (676) 676
met (600) 600
cell line, tumor (573) 573
cancer (570) 570
middle aged (538) 538
mutation (520) 520
c-met (500) 500
kinases (481) 481
aged (477) 477
tumors (470) 470
mice (439) 439
proto-oncogene proteins c-met - antagonists & inhibitors (423) 423
c-met protein (413) 413
adult (395) 395
signal transduction (385) 385
cell biology (376) 376
lung cancer (374) 374
tyrosine (362) 362
gene amplification (340) 340
lung neoplasms - genetics (339) 339
metastasis (334) 334
hepatocyte growth factor (328) 328
gene expression (325) 325
immunohistochemistry (320) 320
genetic aspects (312) 312
research (307) 307
prognosis (303) 303
phosphorylation (298) 298
analysis (296) 296
proteins (293) 293
lung neoplasms - drug therapy (282) 282
protein kinase inhibitors - pharmacology (263) 263
growth factors (259) 259
antineoplastic agents - pharmacology (253) 253
aged, 80 and over (249) 249
hepatocyte growth factor - metabolism (248) 248
lung neoplasms - pathology (241) 241
biochemistry & molecular biology (236) 236
gene expression regulation, neoplastic (233) 233
care and treatment (232) 232
protein-tyrosine kinase (232) 232
epidermal growth factor (229) 229
carcinoma, non-small-cell lung - genetics (216) 216
antineoplastic agents - therapeutic use (215) 215
health aspects (213) 213
research article (204) 204
carcinoma, non-small-cell lung - drug therapy (200) 200
signal transduction - drug effects (200) 200
cell proliferation (198) 198
protein kinase inhibitors - therapeutic use (198) 198
cancer therapies (197) 197
cell proliferation - drug effects (195) 195
pathology (194) 194
apoptosis (193) 193
epidermal growth factor receptors (193) 193
science & technology - other topics (192) 192
medical prognosis (190) 190
multidisciplinary sciences (190) 190
patients (190) 190
receptor, epidermal growth factor - genetics (188) 188
xenograft model antitumor assays (180) 180
chemotherapy (178) 178
hgf (175) 175
medicine (174) 174
egfr (173) 173
gastric cancer (168) 168
molecular targeted therapy (161) 161
carcinoma, non-small-cell lung - pathology (160) 160
development and progression (158) 158
metastases (158) 158
studies (154) 154
mice, nude (152) 152
receptor, epidermal growth factor - metabolism (151) 151
neoplasm staging (148) 148
cell growth (147) 147
lung cancer, non-small cell (147) 147
breast cancer (146) 146
genes (143) 143
adenocarcinoma - genetics (139) 139
hepatocyte growth factor - genetics (139) 139
lung neoplasms - metabolism (138) 138
drug resistance, neoplasm - genetics (137) 137
pharmacology & pharmacy (135) 135
receptor, epidermal growth factor - antagonists & inhibitors (135) 135
stomach neoplasms - genetics (134) 134
proto-oncogene proteins c-met (133) 133
drug resistance, neoplasm (132) 132
medicine, research & experimental (131) 131
non-small cell lung cancer (130) 130
respiratory system (130) 130
research & experimental medicine (129) 129
drug resistance (128) 128
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2645) 2645
Chinese (21) 21
French (18) 18
Japanese (7) 7
Spanish (3) 3
Hungarian (2) 2
Portuguese (2) 2
German (1) 1
Korean (1) 1
Norwegian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Science (American Association for the Advancement of Science), ISSN 1095-9203, 05/2007, Volume 316, Issue 5827, pp. 1039 - 1043
.... Here, we describe a gefitinib-sensitive lung cancer cell line that developed resistance to gefitinib as a result of focal amplification of the MET proto-oncogene... 
Tumor cell line | Phosphorylation | Cell lines | Antibodies | Reports | CHO cells | Genetic mutation | Signal amplification | Cell extracts | Tumors | Lung neoplasms | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Enzyme Inhibitors | Receptor, ErbB-3 - metabolism | Cricetulus | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Sulfones - pharmacology | Receptors, Growth Factor - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | CHO Cells | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Cricetinae | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Proto-Oncogene Proteins c-met | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins - genetics | Animals | Gene Amplification | Quinazolines - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Receptors, Growth Factor - metabolism | Gene amplification | Gene mutations | Lung cancer | Physiological aspects | Genetic aspects | Chemical properties | Drug resistance | Gefitinib | Drug therapy | Health aspects | Oncology | Inhibitor drugs | Index Medicus
Journal Article
Cancer discovery, ISSN 2159-8290, 06/2013, Volume 3, Issue 6, pp. 658 - 673
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 02/2012, Volume 109, Issue 8, pp. 3041 - 3046
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 12/2007, Volume 104, Issue 52, pp. 20932 - 20937
Journal Article
Cancer science, ISSN 1347-9032, 06/2018, Volume 109, Issue 6, pp. 1775 - 1786
Gefitinib has been widely used in the first‐line treatment of advanced EGFR‐mutated non‐small‐cell lung cancer (NSCLC). However, many NSCLC patients will... 
c‐Met | gefitinib resistance | Akt | NSCLC | KLF4 | c-Met | Life Sciences & Biomedicine | Oncology | Science & Technology | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | Male | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Tumor Burden - genetics | Antineoplastic Agents - pharmacology | Gefitinib | Lung Neoplasms - genetics | A549 Cells | Cell Line | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Proto-Oncogene Proteins c-met - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Gene Amplification | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Kruppel-Like Transcription Factors - genetics | Phosphorylation | Transcription factors | Epidermal growth factor receptors | Lung cancer | Non-small cell lung carcinoma | AKT protein | Infections | Breast cancer | Kinases | Cancer therapies | Studies | Signal transduction | Cell growth | Epidermal growth factor | KLF4 protein | Plasmids | Tumorigenesis | Mutation | Genetic testing | Telomerase | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | Original
Journal Article