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Cancer Letters, ISSN 0304-3835, 06/2013, Volume 334, Issue 1, pp. 5 - 9
► P-Postalbelling is an ultrasensitive method for detection of carcinogen-DNA adducts. ► It is widely applied to diverse types of DNA lesions of endogenous and... 
Metabolic activation | Carcinogens | Biomonitoring | DNA adducts
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 261 - 261
Conference Proceeding
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 652 - 652
Conference Proceeding
2016, Nutraceuticals, ISBN 1482253631, Volume 4, xxi, 252
Recent major shifts in global health care management policy have been instrumental in renewing interest in herbal medicine. However, literature on the... 
MEDICAL / Pharmacology | Herbs | Separation | Biotransformation (Metabolism) | Plant Extracts | Enriched foods | Plant bioactive compounds | Phytotherapy | Food, Fortified | Therapeutic use | Complementary & Alternative Medicine | Natural Products | Nutraceuticals & Functional Foods
Book
Science of the Total Environment, ISSN 0048-9697, 12/2019, Volume 697, pp. 134040 - 134040
Polybrominated biphenyls (PBBs) were widely used as additive brominated flame retardants. Their hydroxylated products (OH-PBBs) have been detected frequently... 
Metabolic activation | Endocrine disrupting effect | Hydroxylated brominated biphenyls | Molecular interactions | Index Medicus
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 173 - 173
Conference Proceeding
2017, ISBN 0128125225, Volume 11
This chapter introduces the bioactivation and toxicity of bis-benzylisoquinoline alkaloid, particularly their pulmonary toxicity. It starts with a brief... 
toxicities | bisbenzylisoquinoline | metabolic activation | alkaloids
Book Chapter
2010, ISBN 9780470519271, xxix, 402
John Whittall CoEBio3, Manchester Interdisciplinary Biocentre, Manchester University, UK Peter W Sutton GlaxoSmithKline Research and Development Limited, UK. 
Technology | Material Science | Enzymes | Biotechnology | Synthesis | Biotransformation (Metabolism) | Organic compounds
Book
Archives of Pharmacal Research, ISSN 0253-6269, 04/2012, Volume 35, Issue 4, pp. 733 - 738
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2011, Volume 96, Issue 6, pp. 1844 - 1851
The present study for the first time evaluates the o,p'DDD metabolites as potential predictors of anti-tumor activity in adrenocortical carcinoma. Context: In... 
ORTHO,PARA'-DDD | ADJUVANT MITOTANE | SERIES | RESECTION | LONG-TERM SURVIVAL | ENDOCRINOLOGY & METABOLISM | METABOLIC-ACTIVATION | FRENCH-ASSOCIATION | ADRENAL-CORTICAL CARCINOMA | CANCER | CHEMOTHERAPY
Journal Article
2012, ISBN 9783527329038, xxix, 724
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of... 
Toxicology | Biotransformation (Metabolism) | Xenobiotics | Metabolism | Medical | Drugs
Book
Environmental and molecular mutagenesis, ISSN 0893-6692, 8/2016, Volume 57, Issue 7, pp. 546 - 558
Previous work with a diverse set of reference chemicals suggests that an in vitro multiplexed flow cytometry-based assay (MultiFlow™ DNA Damage Kit—p53, γH2AX,... 
genotoxicity | flow cytometry | γH2AX | metabolic activation | p53
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 2019, Volume 32, Issue 4, pp. 681 - 690
Nitrofurantoin (NFT) is a widely used antimicrobial agent in the treatment of specific urinary tract infections (UTIs). Many adverse effects associated with... 
OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | ASSAY | VIVO | BIOACTIVATION | METABOLIC-ACTIVATION | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | GLUTATHIONE | GENERATION | TOXICOLOGY | HEPATOTOXICITY | DERIVATIVES
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 10/2018, Volume 31, Issue 10, pp. 1052 - 1060
1,3,8-Trihydroxy-6-methylanthraquinone (emodin), a widely existing natural product in herbal medicines, has been reported to be hepatotoxic, but the exact... 
CHEMISTRY, MEDICINAL | ENZYMES | HEPG2 CELLS | RATS | BIOACTIVATION | METABOLIC-ACTIVATION | MICE | TOXICOLOGY | CYTOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | INDUCED HEPATOTOXICITY
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018
Differentiated HepaRG cells maintain liver-specific functions such as drug-metabolizing enzymes. In this study, the feasibility of HepaRG cells as a human... 
Metabolic activation | Drug-induced liver injury | HepG2 cells | HepaRG cells | metabolites | hepatocytes
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 12/2007, Volume 67, Issue 23, pp. 11141 - 11146
CYP2E1 metabolizes many low-molecular weight toxins and carcinogens. Some in vitro experiments suggest that CYP2E1 may be involved in the metabolic activation... 
CYTOCHROME P450 2E1 | N-NITROSODIETHYLAMINE | OXIDATIVE STRESS | ONCOLOGY | NITROSODIMETHYLAMINE | NITROSODIALKYLAMINES | METABOLIC-ACTIVATION | MICE | HEPATOCYTE DEATH | HUMAN-LIVER-MICROSOMES | CELL-DEATH
Journal Article
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