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Toxicology and applied pharmacology, ISSN 0041-008X, 12/2012, Volume 265, Issue 3, pp. 360 - 367
Aristolochic acid causes a specific nephropathy (AAN), Balkan endemic nephropathy, and urothelial malignancies. Using Western blotting suitable to determine... 
Mouse models | Metabolic activation | Protein expression | NAD(P):quinone oxidoreductase | DNA adducts | Balkan endemic nephropathy | Aristolochic acid nephropathy | Aristolochic acid nephropathy$Balkan endemic nephropathy$NAD(P):quinone oxidoreductase$Protein expression$Metabolic activation$DNA adducts$Mouse models | UROTHELIAL CANCER | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | ARISTOLACTAM-DNA ADDUCTS | METABOLIC-ACTIVATION | CYTOCHROMES P450 1A1 | CHINESE HERBS NEPHROPATHY | ARYL-HYDROCARBON RECEPTOR | GENE-EXPRESSION | ENVIRONMENTAL CARCINOGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Cytochrome P-450 CYP1A1 - genetics | Liver - enzymology | Humans | DNA Adducts - metabolism | Cytosol - enzymology | Aristolochic Acids - pharmacokinetics | Liver - drug effects | Cytochrome P-450 CYP1A2 - genetics | Cytochrome P-450 CYP1A2 - deficiency | Female | Cytochrome P-450 CYP1A1 - deficiency | Aristolochic Acids - toxicity | Cell Line | Balkan Nephropathy - genetics | Balkan Nephropathy - metabolism | Liver - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Cytochrome P-450 CYP1A1 - metabolism | Cytochrome P-450 CYP1A2 - metabolism | Blotting, Western | Mice, Knockout | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Balkan Nephropathy - enzymology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Cytosol - metabolism | Mice | Index Medicus | Enzymes | Cytochrome P450 | Liver | Lung | Genotoxicity | Transgenic mice | Aristolochic acid | Malignancy | CYP1A2 protein | Kidney | Western blotting | NAD(P)H:quinone oxidoreductase | Carcinogens | Nephropathy | DNA | NAD(P)H dehydrogenase (quinone) | Adducts | SULFATES | HYDROCARBONS | CARCINOGENS | METABOLIC ACTIVATION | THIN-LAYER CHROMATOGRAPHY | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | ECR HEATING | DNA ADDUCTS | KIDNEYS | NAD | OXYGEN | URINARY TRACT | ENZYMES | LIVER | CARCINOMAS | RECEPTORS | TRANSGENIC MICE
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