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2012, 1. Aufl., EXS, ISBN 303480363X, Volume no. 103., x, 285
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very... 
Metalloproteinases | Inhibitors | Biology, life sciences | Pharmacology
Book
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2005, Volume 288, Issue 2, pp. 461 - 468
The balance between matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), plays a critical role... 
Matrix metalloproteinase | Proliferation | Apoptosis | Phenotypic differentiation | DEATH DOMAIN | CELLS | phenotypic differentiation | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | proliferation | RAT | apoptosis | FAILING HUMAN HEART | GROWTH-FACTOR-BETA | matrix metalloproteinase | RECOMBINANT ADENOVIRUSES | MYOFIBROBLASTS | PERIPHERAL VASCULAR DISEASE | MOLECULAR-CLONING | EXPRESSION | Humans | Actins - metabolism | Culture Media, Conditioned - pharmacology | Tissue Inhibitor of Metalloproteinase-3 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinases - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Myocardium - metabolism | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Adenoviridae - genetics | Fibroblasts - metabolism | Tissue Inhibitor of Metalloproteinase-3 - genetics | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Tissue Inhibitor of Metalloproteinases - antagonists & inhibitors | Cells, Cultured | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinases - metabolism | Myocardium - cytology | Cell Division - physiology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Fibroblasts - cytology | Mice | Apoptosis - physiology | Tissue Inhibitor of Metalloproteinase-2 - antagonists & inhibitors
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 06/2015, Volume 15, Issue 9, pp. 762 - 775
The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles... 
1,3,4-thiadiazoles | Cyclooxygenase inhibitors | Leishmanicidal agents | Metalloproteinases inhibitors | Anticonvulsant activity | Diuretics | Carbonic anhydrase inhibitors | Anticancer agents | VITRO ANTITUBERCULOSIS ACTIVITY | CHEMISTRY, MEDICINAL | leishmanicidal agents | GYNECOLOGIC-ONCOLOGY-GROUP | SELECTIVE PDE7 INHIBITORS | HELICOBACTER-PYLORI ACTIVITY | HUMAN ISOFORM-II | IN-VITRO | metalloproteinases inhibitors | anticonvulsant activity | carbonic anhydrase inhibitors | diuretics | AMINOPEPTIDASE-N INHIBITORS | cyclooxygenase inhibitors | SUBSTITUTED 1,3,4-THIADIAZOLES | CARBONIC-ANHYDRASE INHIBITORS | Phosphodiesterase Inhibitors - therapeutic use | Carbonic Anhydrase Inhibitors - chemistry | Humans | Matrix Metalloproteinase Inhibitors - chemistry | Antineoplastic Agents - therapeutic use | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Matrix Metalloproteinase Inhibitors - therapeutic use | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Animals | Phosphodiesterase Inhibitors - metabolism | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Protein Binding | Phosphodiesterase Inhibitors - chemistry | Thiadiazoles - metabolism | Carbonic Anhydrase Inhibitors - metabolism | Cyclooxygenase Inhibitors - therapeutic use | Quantitative Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - therapeutic use
Journal Article
Journal Article
Cardiovascular Research, ISSN 0008-6363, 06/2013, Volume 98, Issue 3, pp. 360 - 371
Hypertension is accompanied by structural remodelling of vascular extracellular matrix (ECM). Tissue inhibitor of metalloproteinases (TIMPs) inhibits matrix... 
Hypertension | Tissue inhibitor of metalloproteinase | Extracellular matrix | Vascular remodelling | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ABDOMINAL AORTIC-ANEURYSMS | ANGIOTENSIN-II | MATRIX METALLOPROTEINASES | CELLS IN-VIVO | TISSUE INHIBITOR | DOXYCYCLINE | EXTRACELLULAR-MATRIX | DYSFUNCTION | EXPRESSION | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Mesenteric Arteries - physiopathology | Mesenteric Arteries - pathology | Mesenteric Arteries - drug effects | Tissue Inhibitor of Metalloproteinase-2 - genetics | Vasodilation | Tissue Inhibitor of Metalloproteinases - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Time Factors | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Arterial Pressure - drug effects | Gelatinases - metabolism | Hypertension - prevention & control | Tissue Inhibitor of Metalloproteinase-3 - deficiency | Hypertension - genetics | Angiotensin II | Disease Models, Animal | Tissue Inhibitor of Metalloproteinase-3 - genetics | Elastin - metabolism | Gelatinases - antagonists & inhibitors | Mice, Inbred C57BL | Vasoconstriction | Mesenteric Arteries - metabolism | Hypertension - pathology | Hypertension - physiopathology | Tissue Inhibitor of Metalloproteinases - metabolism | Hypertension - metabolism | Mice, Knockout | Collagen - metabolism | Matrix Metalloproteinase Inhibitors - pharmacology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Carotid Arteries - physiopathology | Carotid Arteries - pathology | Mice
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2004, Volume 378, Issue 3, pp. 705 - 716
The proteins that inhibit peptidases are of great importance in medicine and biotechnology, but there has never been a comprehensive system of classification... 
Journal Article
Cancer Research, ISSN 0008-5472, 05/2005, Volume 65, Issue 10, pp. 3967 - 3979
Journal Article
Microbial Cell Factories, ISSN 1475-2859, 04/2017, Volume 16, Issue 1, pp. 73 - 12
Background: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a... 
Tissue inhibitor of metalloproteinase | Periplasmic expression | Disulfide isomerase | Matrix metalloproteinase | Contact guidance | CELLS | TIMP-1 | BINDING-PROTEIN | GLYCOSYLATION | AMINO-TERMINAL DOMAIN | MATRIX METALLOPROTEINASES | OVEREXPRESSION | PROGELATINASE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PURIFICATION | Recombinant Proteins - metabolism | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Periplasm - enzymology | Protein Disulfide-Isomerases - metabolism | Humans | Solubility | Protein Folding | Tissue Inhibitor of Metalloproteinase-2 - genetics | Epitopes - immunology | Metalloproteases - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-1 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Protein Disulfide-Isomerases - genetics | Periplasm - metabolism | Tissue Inhibitor of Metalloproteinase-2 - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Tissue Inhibitor of Metalloproteinase-2 - pharmacology | Tissue Inhibitor of Metalloproteinase-1 - chemistry | Cell culture | Media (culture) | Leukocyte migration | Cytology | Antibodies | Arthritis | Metastasis | Tissue inhibitor of metalloproteinase 2 | Tissue inhibitor of metalloproteinase 1 | Monomers | Cell morphology | Proteins | E coli | Inclusion bodies | Periplasmic space | Fibroblasts | Chemical bonds | Extracellular matrix | Physiology | Enzyme-linked immunosorbent assay | Interstitial collagenase | Disulfide bonds | ADAM protein | Secretion | Bioassays | T cell receptors | Epitopes | Mutants | Neurological diseases | Inhibitors | Insects | Arteriosclerosis | Culture media | Cell migration | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2018, Volume 13, Issue 4, p. e0195116
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation... 
MATRIX METALLOPROTEINASES | DEATH DOMAIN | OVEREXPRESSION | LEUKEMIC-CELLS | CD95 | INVASION | MECHANISM | REDISTRIBUTION | MULTIDISCIPLINARY SCIENCES | LIPID RAFTS | PROLIFERATION | Disintegrins - metabolism | Muscle, Smooth, Vascular - metabolism | Apoptosis - drug effects | Humans | Cells, Cultured | fas Receptor - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Muscle, Smooth, Vascular - cytology | fas Receptor - metabolism | ADAM17 Protein - metabolism | Microscopy, Confocal | ADAM17 Protein - genetics | Caspases - metabolism | ADAM17 Protein - antagonists & inhibitors | RNA Interference | Tissue Inhibitor of Metalloproteinase-3 - metabolism | fas Receptor - genetics | Disintegrins - antagonists & inhibitors | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Staurosporine - pharmacology | RNA, Small Interfering - metabolism | Tissue Inhibitor of Metalloproteinase-3 - genetics | Medical research | Tumor necrosis factor | Physiological aspects | Medicine, Experimental | Research | Vascular smooth muscle | Health aspects | Apoptosis | Shedding | Immunoprecipitation | Smooth muscle | Lipids | Infections | Activation | Tissue inhibitor of metalloproteinase 3 | Caspase-3 | Cell surface | Proteins | Fas-associated protein | FADD protein | Signal transduction | Mitochondria | Rodents | FLIP protein | Interleukin 1 | Inhibition | Enzymes | ADAM protein | Cytokines | Mortality | Muscles | Caspase | c-FLIP protein | Clustering | Lymphoma | Caspase-8 | Signaling | Depletion | Overexpression | Inhibitors | Lymphocytes B | Adenoviruses | Caspase-9 | Death | Position (location) | Immunofluorescence | Cancer | B-cell lymphoma
Journal Article