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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 16, pp. 4140 - 4145
Mutations of the KRAS gene are found in human cancers with high frequency and result in the constitutive activation of its protein products. This leads to... 
Posttranslational modification | Top-down proteomics | KRAS | Immunoprecipitation | RAS | TRANSFORMATION | ACTIVATION | posttranslational modification | ONCOGENIC KRAS | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | CANCER | METHYLATED KRAS4B | K-RAS | top-down proteomics | STRUCTURAL BASIS | immunoprecipitation | RAS ISOFORMS | SUPERFAMILY | Prenylation | Colorectal Neoplasms - genetics | Humans | Mutation, Missense | Tandem Mass Spectrometry | Proto-Oncogene Proteins p21(ras) - chemistry | Chromatography, Liquid | Cell Membrane - metabolism | Proto-Oncogene Proteins p21(ras) - analysis | Proteomics - methods | Amino Acid Sequence | Proto-Oncogene Proteins p21(ras) - isolation & purification | Colorectal Neoplasms - enzymology | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Cysteine - chemistry | Nitrosation | Sequence Homology, Amino Acid | Point Mutation | Sequence Alignment | Neoplasm Proteins - isolation & purification | Cell Line, Tumor | Neoplasm Proteins - analysis | Protein Conformation | Protein Processing, Post-Translational | Methylation | Genetic aspects | Cellular signal transduction | Health aspects | Mutation (Biology) | Colorectal cancer | Cell survival | Genes | Crosstalk | Colorectal carcinoma | Workflow | Mass spectroscopy | Tumor cell lines | Cells | K-Ras protein | Proteins | Immunology | Proteomics | Cell lines | Carboxymethylation | Tumorigenesis | Mutation | Mass spectrometry | Genotypes | Cancer | Tumors | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 11/2018, Volume 151, pp. 99 - 105
Protein prenylation is a vital eukaryotic post-translational modification which permits interaction of proteins with cellular membranes. Prenylated proteins... 
Prenylation | Geranylgeranylation | Protein production | Baculovirus | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PROTEIN FARNESYLTRANSFERASE | METHYLATED KRAS4B | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BACK | MICE | INHIBITORS | JUVENILE-HORMONE | Post-translational modification | Enzymes | Ionization | Mass spectrometry | Sugars | Protein binding
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 487, Issue 2, pp. 351 - 355
KRas4b is a small G-protein whose constitutively active oncogenic mutants are present in 90% of pancreatic cancers. Using fully post-translationally modified... 
Nanodisc | Lipid specificity | KRas4b | Cancer signaling | PIP2 | PHOSPHOLIPID-BILAYER NANODISCS | MOLECULAR-DYNAMICS | ACTIVATION | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MIMETIC MODEL | METHYLATED KRAS4B | BIOPHYSICS | STRUCTURAL BASIS | PROTEINS | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 8461 - 15
Activation of RAF kinase involves the association of its RAS-binding domain (RBD) and cysteine-rich domain (CRD) with membrane-anchored RAS. However, the... 
DYNAMICS SIMULATIONS | PHOSPHOLIPID-BILAYER NANODISCS | METHYLATED KRAS4B | PROTEIN-KINASE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ZINC-FINGER | KINASE-C-ALPHA | BINDING DOMAIN | LIQUID WATER | B-RAF | Interfaces | Cysteine | Nuclear magnetic resonance--NMR | Hydrophobicity | Simulation | Dimerization | BASIC BIOLOGICAL SCIENCES | Biological Science
Journal Article
Chinese Chemical Letters, ISSN 1001-8417, 07/2018, Volume 29, Issue 7, pp. 1043 - 1050
We summarized the developed strategies including chemical total synthesis, biosynthesis and semi-synthesis for producing Ras proteins with modification and... 
Multi-PTMs | Ras | Lipopeptides | Semi-synthesis | Biophysical function | SOLID-PHASE SYNTHESIS | BCL-XL | LIPIDATED RAS | CHEMISTRY, MULTIDISCIPLINARY | FARNESYL GROUP | METHYLATED KRAS4B | UBIQUITIN CHAINS | H-RAS | MEMBRANE-BINDING | PDE-DELTA | CHEMICAL-SYNTHESIS | Protein research | Protein biosynthesis | Research
Journal Article
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