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Nature Immunology, ISSN 1529-2908, 01/2011, Volume 12, Issue 1, pp. 29 - 36
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2008, Volume 65, Issue 1, pp. 69 - 77
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Up to 30% of inflammatory bowel disease patients treated with the thiopurine drugs azathioprine and 6-mercaptopurine... 
IMPDH | azathioprine | 6-mercaptopurine | thiopurine | inflammatory bowel disease | inosine-5′-monophosphate dehydrogenase | 6‐mercaptopurine | inosine‐5′‐monophosphate dehydrogenase | Inflammatory bowel disease | Inosine-5′-monophosphate dehydrogenase | Azathioprine | Thiopurine | METHYLTRANSFERASE ACTIVITY | DEHYDROGENASE-ACTIVITY | HUMAN TYPE-I | INDUCED MYELOSUPPRESSION | inosine-5'-monophosphate dehydrogenase | CROHN-DISEASE | 6-THIOGUANINE NUCLEOTIDE | INOSINE TRIPHOSPHATE PYROPHOSPHATASE | AZATHIOPRINE THERAPY | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | Inflammatory Bowel Diseases - drug therapy | Mercaptopurine - pharmacology | Humans | Methyltransferases - metabolism | Middle Aged | Methyltransferases - genetics | Azathioprine - pharmacology | Male | IMP Dehydrogenase - genetics | Polymorphism, Genetic | IMP Dehydrogenase - metabolism | Aged, 80 and over | Biomarkers | Adult | Female | Aged | Immunosuppressive Agents - pharmacology | Physiological aspects | Enzymes | Purine nucleotides | Metabolites | Gastrointestinal diseases | Pharmacogenetics | 6-Mercaptopurine/pharmacology Adult Aged Aged | 80 and over Azathioprine/pharmacology Biological Markers Female Humans IMP Dehydrogenase/genetics/metabolism Immunosuppressive Agents/pharmacology Inflammatory Bowel Diseases/drug therapy Male Methyltran | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Science, ISSN 0036-8075, 12/2012, Volume 338, Issue 6113, pp. 1465 - 1469
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 2004, Volume 75, Issue 5, pp. 807 - 821
Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the prefrontal cortex of the human brain. Genetic variation in the gene... 
THERMAL-STABILITY | DORSOLATERAL PREFRONTAL CORTEX | IMMUNOREACTIVITY | GENOTYPE | GENETICS & HEREDITY | SCHIZOPHRENIA | MICE | BIPOLAR DISORDER | DOPAMINE TRANSPORTER | EXPRESSION | BIOCHEMICAL GENETICS | Catechin | Brain research | Research | Human chromosomes | Analysis
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2018, Volume 13, Issue 14, pp. 1405 - 1413
SETD7 is a histone H3K4 lysine methyltransferase involved in human gene regulation. Aberrant expression of SETD7 has been associated with various diseases,... 
(R)-PFI-2 | structure–activity relationships | histone lysine methyltransferase | epigenetics | SETD7 | PROTEIN METHYLTRANSFERASES | CELLS | CHEMISTRY, MEDICINAL | STABILITY | TRANSCRIPTION | SET7/9 | CANCER | SET9-MEDIATED METHYLATION | CYPROHEPTADINE | structure-activity relationships | SELECTIVE INHIBITORS | PHARMACOLOGY & PHARMACY | DERIVATIVES | Recombinant Proteins - metabolism | Small Molecule Libraries - pharmacology | Tetrahydroisoquinolines - pharmacology | Sulfonamides - chemistry | Humans | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Structure-Activity Relationship | Tetrahydroisoquinolines - chemical synthesis | Enzyme Inhibitors - chemical synthesis | Sulfonamides - pharmacology | Pyrrolidines - chemistry | Pyrrolidines - pharmacology | Histone-Lysine N-Methyltransferase - chemistry | Small Molecule Libraries - chemistry | Sulfonamides - chemical synthesis | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Histone-Lysine N-Methyltransferase - metabolism | Pyrrolidines - chemical synthesis | Tetrahydroisoquinolines - chemistry | Enzyme Inhibitors - chemistry | Epigenesis, Genetic - drug effects | Molecular Docking Simulation | Epigenetic inheritance | Lysine | Hydrogen | Transferases | Inhibitors | Hydrogen bonds | Gene regulation | Methyltransferase | Drug development | Gene expression | Molecular chains | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12853 - 12858
SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported... 
Enzymes | Transcriptional regulatory elements | Genes | Cell lines | Histones | Gene expression regulation | Kinetics | Methylation | Inhibitory concentration 50 | Chemicals | Chemical biology | Epigenetics | Chemical probe | METHYLATION | STABILITY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SET7/9 | epigenetics | LYSINE METHYLTRANSFERASE | ENZYME | chemical biology | PATHWAY | PURIFICATION | GENES | chemical probe | Humans | Methyltransferases - metabolism | Structure-Activity Relationship | Phosphoproteins - metabolism | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | MCF-7 Cells | Tetrahydroisoquinolines - chemistry | Enzyme Inhibitors - chemistry | Epigenesis, Genetic - drug effects | Protein Structure, Tertiary | Tetrahydroisoquinolines - pharmacology | Histone-Lysine N-Methyltransferase - genetics | Sulfonamides - chemistry | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Phosphoproteins - genetics | Sulfonamides - pharmacology | Pyrrolidines - chemistry | Methyltransferases - antagonists & inhibitors | Histone-Lysine N-Methyltransferase - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Adaptor Proteins, Signal Transducing - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Protein research | Research | Methyltransferases | Lysine | Health aspects | Protein-protein interactions | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 2, pp. 247 - 261
Journal Article
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 07/2017, Volume 42, Issue 7, pp. 531 - 542
Journal Article
The Plant Cell, ISSN 1040-4651, 6/2013, Volume 25, Issue 6, pp. 2341 - 2355