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Pediatrics, ISSN 0031-4005, 07/2011, Volume 128, Issue 1, pp. e152 - e159
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 8/2015, Volume 12, Issue 2, pp. 2643 - 2649
The metabolic products of intracellular mevalonate (MVA) are important for the growth of eukaryotic cells. These products include cholesterol and several... 
apoptosis | mesangial cell | mevalonate | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | ONCOLOGY | RECEPTOR | TGF-BETA-1 | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transforming Growth Factor beta1 - metabolism | Extracellular Matrix - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Mesangial Cells - drug effects | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-bcl-2 - metabolism | Collagen Type I - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | bcl-2-Associated X Protein - genetics | Collagen Type IV - metabolism | Mevalonic Acid - pharmacology | Cell Line | Collagen Type I - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Extracellular Matrix - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Mesangial Cells - cytology | Imidazoles - pharmacology | Transforming Growth Factor beta1 - genetics | Mesangial Cells - metabolism | Anthracenes - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Collagen Type IV - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Glomerulonephritis | Mevalonate | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Mitogen-activated protein kinases | Cell proliferation | Bioengineering | Flow cytometry | Transcription factors | Collagen (type I) | Disease | Bax protein | Bcl-2 protein | Kinases | Proteins | Engineering | Cell growth | Metabolites | Cell cycle | Mesangial cells | Extracellular matrix | Coenzyme A | Standard deviation | Collagen (type IV) | Enzyme-linked immunosorbent assay | Secretion | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Lymphoma | Cholesterol | Lymphocytes B | Protein kinase | Collagen | Hydroxymethylglutaryl-CoA reductase | Terpenes | Apoptosis | B-cell lymphoma
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2003, Volume 278, Issue 44, pp. 43603 - 43614
Journal Article
Revue de Medecine Interne, ISSN 0248-8663, 04/2018, Volume 39, Issue 4, pp. 265 - 270
Mevalonate kinase deficiency is a rare, autosomal recessive, auto-inflammatory disease. This results from mutations in the gene MVK coding for the enzyme... 
Metabolic disorder | Mevalonate aciduria | Autoinflammatory syndrome | Hyper-IgD syndrome | Mevalonate kinase deficiency
Journal Article
by Zhu, T and Tian, D and Zhang, L and Xu, X and Xia, K and Hu, Z and Xiong, Z and Tan, J
British Journal of Dermatology, ISSN 0007-0963, 08/2019, Volume 181, Issue 2, pp. 304 - 313
What's already known about this topic The mevalonate kinase gene ( MVK ) has been reported as pathogenic in disseminated superficial actinic porokeratosis (... 
Medicine, Experimental | Medical research | Mevalonate kinase | Cycloheximide | Mitochondria | Mevalonic acid | Missense mutation | Pedigree | Mutation | Kinases | Dimerization | Cholesterol | Glutathione | Apoptosis | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 06/2008, Volume 275, Issue 11, pp. 2779 - 2794
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 2016, Volume 68, Issue 11, pp. 2795 - 2805
ObjectiveMevalonate kinase deficiency (MKD) is a rare metabolic disease characterized by recurrent inflammatory episodes. This study was undertaken to describe... 
MVK | HYPER-IGD | PERIODIC FEVER SYNDROME | ACIDURIA | HYPERIMMUNOGLOBULINEMIA-D | AUTOINFLAMMATORY DISEASES | MUTATIONS | SPECTRUM | RHEUMATOLOGY | Arthralgia - etiology | Uveitis - etiology | Humans | Child, Preschool | Lymphadenopathy - etiology | Male | Arthralgia - physiopathology | Arthritis - genetics | Stomatitis, Aphthous - genetics | Cerebellar Diseases - physiopathology | Amyloidosis - genetics | Skin Diseases - physiopathology | Amyloidosis - etiology | Child | Stomatitis, Aphthous - etiology | Infant, Newborn | Myalgia - physiopathology | Amyloidosis - physiopathology | Genotype | Headache - physiopathology | Vomiting - genetics | Phenotype | Diarrhea - genetics | Abdominal Pain - genetics | Adolescent | Age of Onset | Intellectual Disability - etiology | Uveitis - genetics | Vomiting - physiopathology | Conjunctivitis - etiology | Conjunctivitis - genetics | Arthritis - physiopathology | Headache - etiology | Skin Diseases - genetics | Mevalonate Kinase Deficiency - physiopathology | Myalgia - genetics | Cerebellar Diseases - etiology | Diarrhea - physiopathology | Infant | Mevalonate Kinase Deficiency - genetics | Intellectual Disability - genetics | Pharyngitis - genetics | Arthritis - etiology | Female | Registries | Retrospective Studies | Arthralgia - genetics | Pharyngitis - physiopathology | Abdominal Pain - etiology | Pharyngitis - etiology | Lymphadenopathy - genetics | Abdominal Pain - physiopathology | Myalgia - etiology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Headache - genetics | Intellectual Disability - physiopathology | Skin Diseases - etiology | Cerebellar Diseases - genetics | Conjunctivitis - physiopathology | Mevalonate Kinase Deficiency - complications | Stomatitis, Aphthous - physiopathology | Vomiting - etiology | Diarrhea - etiology | Lymphadenopathy - physiopathology | Uveitis - physiopathology | Kinases | Genotype & phenotype | Index Medicus | Abridged Index Medicus
Journal Article
Pediatrics, ISSN 0031-4005, 09/2013, Volume 132, Issue 3, pp. e779 - e783
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 19, pp. 5886 - 5895
The biosyntheses of isoprenoids is essential for the survival in all living organisms, and requires one of the two biochemical pathways: (a) Mevalonate (MVA)... 
Biodefense | 4-Diphosphocytidyl-2-C-methyl d-erythritol (CDP-ME) | Antibiotics | Antimicrobials | CDP-ME kinase | Gram-negative bacteria | Small molecule inhibitors | Isoprenoid biosynthesis | IspE | Yersinia pestis | Anti-terrorism | 4-Diphosphocytidyl-2-C- methyl d-erythritol (CDP-ME) | MYCOBACTERIUM-TUBERCULOSIS | TEST SYSTEM | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | CHEMISTRY, ORGANIC | NON-MEVALONATE PATHWAY | 4-Diphosphocytidyl-2-C-methyl D-erythritol (CDP-ME) | HUMAN GALACTOKINASE | PATHOGENIC BACTERIA | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Small Molecule Libraries - pharmacology | Escherichia coli - enzymology | Enzyme Inhibitors - pharmacology | Molecular Sequence Data | Escherichia coli Proteins - metabolism | Structure-Activity Relationship | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Sequence Homology, Amino Acid | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Small Molecule Libraries - chemistry | Computer Simulation | Enzyme Inhibitors - chemistry | Bacterial Proteins - metabolism | Escherichia coli Proteins - antagonists & inhibitors | Binding Sites | Yersinia pestis - enzymology | Anti-infective agents | Biological weapons | Medical genetics | Index Medicus
Journal Article