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mevalonate-independent pathway (208) 208
isoprenoid biosynthesis (139) 139
escherichia-coli (80) 80
biochemistry & molecular biology (75) 75
isopentenyl diphosphate (73) 73
plant sciences (72) 72
terpenoid biosynthesis (62) 62
nonmevalonate pathway (61) 61
biosynthesis (59) 59
higher-plants (49) 49
index medicus (48) 48
1-deoxy-d-xylulose 5-phosphate reductoisomerase (45) 45
physiological aspects (43) 43
terpenes - metabolism (40) 40
erythritol - analogs & derivatives (36) 36
molecular sequence data (36) 36
amino acid sequence (33) 33
enzymes (33) 33
heterologous expression (32) 32
erythritol - metabolism (30) 30
plants (30) 30
terpenoids (28) 28
chemistry, organic (27) 27
phosphates (27) 27
sugar phosphates - metabolism (27) 27
arabidopsis-thaliana (26) 26
2-c-methyl-d-erythritol 4-phosphate (24) 24
isoprenoids (24) 24
gene expression (22) 22
methylerythritol phosphate-pathway (22) 22
analysis (20) 20
biophysics (19) 19
precursor (19) 19
research (19) 19
1-deoxy-d-xylulose 5-phosphate synthase (18) 18
cloning (18) 18
cloning, molecular (18) 18
organophosphorus compounds - metabolism (18) 18
1-deoxy-d-xylulose (17) 17
2-c-methyl-d-erythritol 4-phosphate pathway (17) 17
bacteria (17) 17
sequence homology, amino acid (17) 17
transferases - genetics (17) 17
transferases - metabolism (17) 17
1-deoxy-d-xylulose-5-phosphate reductoisomerase (16) 16
aldose-ketose isomerases - genetics (16) 16
gene (16) 16
hemiterpenes (16) 16
higher-plant chloroplasts (16) 16
molecular structure (16) 16
multidisciplinary sciences (16) 16
oxidoreductases - genetics (16) 16
5-phosphate (15) 15
gene expression regulation, plant (15) 15
life sciences (15) 15
microbiology (15) 15
multienzyme complexes - genetics (15) 15
synthase (15) 15
2-c-methyl-d-erythritol (14) 14
mep pathway (14) 14
metabolism (14) 14
plants - metabolism (14) 14
reductoisomerase (14) 14
transketolases (14) 14
4--2-c-methyl-d-erythritol (13) 13
beta-carotene (13) 13
biotechnology & applied microbiology (13) 13
carotenoids (13) 13
carotenoids - biosynthesis (13) 13
fosmidomycin (13) 13
mevalonic acid - metabolism (13) 13
phylogeny (13) 13
protein (13) 13
aldose-ketose isomerases - chemistry (12) 12
base sequence (12) 12
escherichia coli - enzymology (12) 12
escherichia coli - genetics (12) 12
fosfomycin - analogs & derivatives (12) 12
genes (12) 12
genetic aspects (12) 12
methylerythritol phosphate pathway (12) 12
plastids - metabolism (12) 12
1-deoxy-d-xylulose 5-phosphate (11) 11
aldose-ketose isomerases - metabolism (11) 11
carotenoid biosynthesis (11) 11
dimethylallyl diphosphate (11) 11
fosfomycin - pharmacology (11) 11
functional expression (11) 11
metabolic engineering (11) 11
multienzyme complexes - metabolism (11) 11
oxidoreductases - metabolism (11) 11
phytochemistry (11) 11
plant leaves - metabolism (11) 11
sequence alignment (11) 11
thiamin (11) 11
animals (10) 10
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Journal Article
FEBS Letters, ISSN 0014-5793, 2006, Volume 580, Issue 6, pp. 1547 - 1552
In the methylerythritol phosphate pathway for isoprenoid biosynthesis, the GcpE/IspG enzyme catalyzes the conversion of 2- -methyl- -erythritol... 
GcpE | IspG | Ferredoxin | Photosynthesis | Isoprenoid biosynthesis | 2-C-methyl-d-erythritol 2,4-cyclodiphosphate | GcpE, IspG | HMBPP | IPP | MEcDP | HMBPP synthase | (E)-4-hydroxy-3-methylbut-2-enyl diphosphate | isopentenyl diphosphate | 2-C-methyl-d-erythritol 4-phosphate | LytB, IspH | HMBPP reductase | MEP | DMAPP | dimethylallyl diphosphate | isoprenoid biosynthesis | METHYLERYTHRITOL PHOSPHATE-PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAY | HAIRY ROOT CULTURES | ESCHERICHIA-COLI | (E)-4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE | CELL BIOLOGY | ferredoxin | BIOPHYSICS | photosynthesis | ISOPENTENYL DIPHOSPHATE | MYCORRHIZAL ROOTS | MEVALONATE-INDEPENDENT PATHWAY | NONMEVALONATE PATHWAY | Electron Transport | Arabidopsis - enzymology | Escherichia coli - enzymology | Erythritol - analogs & derivatives | Oxidation-Reduction | Ferredoxins - metabolism | Alkyl and Aryl Transferases - metabolism | Spinacia oleracea - metabolism | Thylakoids - radiation effects | Thylakoids - metabolism | Arabidopsis Proteins - isolation & purification | Arabidopsis Proteins - metabolism | Thylakoids - enzymology | Terpenes - metabolism | Light | Spinacia oleracea - radiation effects | Erythritol - metabolism | Spinacia oleracea - enzymology | Arabidopsis thaliana | Phosphates | Enzymes | Pyridine | Phytochemistry | Physiological aspects | Catalysis
Journal Article
Science, ISSN 0036-8075, 9/1999, Volume 285, Issue 5433, pp. 1573 - 1576
A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of... 
Enzymes | Malaria | Terpenoids | Antimalarials | Amino acids | Apicoplasts | Reports | Parasites | Parasitemia | Dosage | Chromosomes | PARASITE TOXOPLASMA-GONDII | ERYTHROCYTES | HIGHER-PLANTS | APICOMPLEXAN PARASITES | FOSMIDOMYCIN | ISOPENTENYL DIPHOSPHATE | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | TERPENOID BIOSYNTHESIS | MEVALONATE-INDEPENDENT PATHWAY | Oxidoreductases - antagonists & inhibitors | Molecular Sequence Data | Multienzyme Complexes - metabolism | Genes, Protozoan | Organelles - drug effects | Plasmodium falciparum - drug effects | Organophosphorus Compounds - metabolism | Oxidoreductases - chemistry | Terpenes - pharmacology | Plasmodium falciparum - genetics | Cloning, Molecular | Plasmodium falciparum - metabolism | Pentosephosphates - metabolism | Aldose-Ketose Isomerases - metabolism | Fosfomycin - analogs & derivatives | Recombinant Proteins - metabolism | Amino Acid Sequence | Malaria, Falciparum - drug therapy | Aldose-Ketose Isomerases - chemistry | Recombinant Proteins - antagonists & inhibitors | Oxidoreductases - metabolism | Fosfomycin - pharmacology | Oxidoreductases - genetics | Enzyme Inhibitors - pharmacology | Multienzyme Complexes - genetics | Mevalonic Acid - metabolism | Multienzyme Complexes - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Antimalarials - pharmacology | Multienzyme Complexes - chemistry | Malaria, Falciparum - parasitology | Animals | Malaria - parasitology | Hemiterpenes | Mice | Aldose-Ketose Isomerases - genetics | Malaria - drug therapy | Aldose-Ketose Isomerases - antagonists & inhibitors | Organelles - metabolism | Plasmodium | Research | Pharmacology | Biochemistry | Drug therapy
Journal Article
Plant Molecular Biology, ISSN 0167-4412, 9/2007, Volume 65, Issue 1, pp. 177 - 187
Journal Article
Current Organic Chemistry, ISSN 1385-2728, 04/2014, Volume 18, Issue 8, pp. 1050 - 1072
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2004, Volume 279, Issue 50, pp. 51749 - 51759
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2005, Volume 102, Issue 28, pp. 9972 - 9977
Journal Article