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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 3, pp. 814 - 824.e11
Background Respiratory syncytial virus (RSV) is a major health care burden with a particularly high worldwide morbidity and mortality rate among infants. Data... 
Allergy and Immunology | Group 2 innate lymphoid cells | thymic stromal lymphopoietin | IL-13 | type 2 immunity (TH2) | IL-33 | respiratory syncytial virus | type 2 immunity (T | AIRWAY EPITHELIAL-CELLS | ALLERGIC INFLAMMATION | DEXAMETHASONE | type 2 immunity (T(H)2) | TSLP | IL-25 | IMMUNOLOGY | HYPERRESPONSIVENESS | CYTOKINE PRODUCTION | ALLERGY | LUNG INFLAMMATION | T-LYMPHOCYTES | Interleukin-13 - immunology | Interleukin-33 - immunology | Respiratory Syncytial Virus Infections - immunology | Viral Load | Mice, Knockout | Lung - virology | Animals | Lymphocytes - immunology | Female | Mucus - metabolism | Lung - metabolism | Mice, Inbred BALB C | Respiratory Syncytial Virus Infections - virology | Cytokines - genetics | Lung - immunology | Cytokines - immunology | Virus diseases | Medical colleges | Infants | Health aspects | Mortality | Analysis | Asthma | Proteins | Ostomy | Disease | Lungs | Cytokines | Viruses | Infections | Immune Deficiencies, Infection, and Systemic Immune Disorders | MFI, Mean fluorescence intensity | BAL, Bronchoalveolar lavage | WT, Wild-type | TSLP, Thymic stromal lymphopoietin | KO, Knockout | INSPIRE, Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure | PAS, Periodic acid–Schiff | ILC2, Group 2 innate lymphoid cell | TSLPR, Thymic stromal lymphopoietin receptor | ILC, Innate lymphoid cell | RSV, Respiratory syncytial virus | PFU, Plaque-forming units
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1394 - 1401.e4
Background Naturally occurring IgE-specific IgG autoantibodies have been identified in patients with asthma and other diseases, but their spectrum of functions... 
Allergy and Immunology | autoantibodies | IgE | basophil activation | Asthma | basophil inhibition | CELLS | ALPHA AUTOANTIBODIES | FC-EPSILON-RI | CHRONIC IDIOPATHIC URTICARIA | COMPLEXES | CROSS-LINKING | RECEPTOR | IMMUNOLOGY | ATOPIC-DERMATITIS | ALLERGY | SEVERITY | BRONCHIAL-ASTHMA | Cell Line | Immunoglobulin G - blood | Antibodies, Anti-Idiotypic - blood | Autoantibodies - blood | Humans | Antibodies, Anti-Idiotypic - immunology | Rats | Antigens, Plant - immunology | Phleum - immunology | Autoantibodies - immunology | Animals | Immunoglobulin E - immunology | Allergens - immunology | Calcium-Binding Proteins - immunology | Immunoglobulin G - immunology | Asthma - blood | Asthma - immunology | Basophils - immunology | Receptors, IgE - immunology | Autoimmunity | Allergens | Allergy | Autoantibodies | Immunoglobulin G | Immunoglobulin E | Allergic reaction | Studies | Medical research | Hospitals | Biomedical research | Health services | Immunotherapy | Allergies | Immune system | MP, Milk powder | NAC, Non-atopic controls | FACS, Fluorescence-activated cell sorting | FITC, Fluorescein | AA, Atopic asthmatic subjects | MFI, Mean fluorescence intensity | PEFR, Peak expiratory flow rate | SPT, Skin prick test | ANA, Anti-nuclear autoantibodies | APC, Allophycocyanin | Tween 20 | HDM, House dust mite | PE, R-Phycoerythrin | BAT, Basophil activation test | NAA, Non-atopic asthmatic subjects | RT, Room temperature | HRP, Horseradish peroxidase | PBS-T, Phosphate-buffered saline | Mechanisms of Allergy and Clinical Immunology
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 6/2011, Volume 52, Issue 6, pp. 1098 - 1107
Monoclonal antibody (MoAb)-based therapies have opened innovative treatment avenues that have impacted on the management of patients with both neoplastic and... 
mean fluorescence intensity (MFI) | monoclonal antibody therapy | antigen expression | antibody binding capacity (ABC) | Acute lymphoid leukemia (ALL) | GEMTUZUMAB OZOGAMICIN | CHEMOIMMUNOTHERAPY | CHEMOTHERAPY | IN-VITRO | INDUCTION THERAPY | ONCOLOGY | RITUXIMAB | LYMPHOMA | PRECURSOR-B | MONOCLONAL-ANTIBODIES | HEMATOLOGY | EXPRESSION | Antigens, CD - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Flow Cytometry - methods | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Middle Aged | Child, Preschool | Antibodies, Monoclonal - therapeutic use | Sialic Acid Binding Ig-like Lectin 2 - immunology | Antigens, CD - metabolism | Young Adult | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Aged, 80 and over | Adult | Transcription, Genetic | Sialic Acid Binding Ig-like Lectin 3 | Child | Antibodies, Monoclonal - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Antigens, CD19 - immunology | Antigens, CD20 - immunology | Immunophenotyping | Antigens, CD20 - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - therapy | Reverse Transcriptase Polymerase Chain Reaction | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Oncogene Proteins, Fusion - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Aged | Antigens, CD19 - metabolism
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2010, Volume 397, Issue 3, pp. 826 - 834
malaria remains one of the world's leading causes of human suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan Africa.... 
CSA | VAR2CSA | vaccine | malaria | PfEMP1 | PROTEOGLYCANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFECTED ERYTHROCYTES | ADHERENCE | PREGNANCY-ASSOCIATED MALARIA | CHONDROITIN-SULFATE-A | GENE | SURFACE | CYTOADHERENCE | CYTOADHESION | DOMAINS | Recombinant Proteins - metabolism | Surface Plasmon Resonance | Malaria, Falciparum - genetics | Antigens, Protozoan - immunology | Chondroitin Sulfates - metabolism | Enzyme-Linked Immunosorbent Assay | Antibodies, Protozoan - immunology | Glycosaminoglycans - metabolism | Rats | Recombinant Proteins - genetics | Plasmodium falciparum - immunology | Recombinant Proteins - isolation & purification | Antigens, Protozoan - metabolism | Animals | Flow Cytometry | Plasmodium falciparum - genetics | Cloning, Molecular | Erythrocytes - metabolism | Malaria, Falciparum - immunology | Malaria, Falciparum - metabolism | Antigens, Protozoan - genetics | Erythrocytes - parasitology | Antibodies, Protozoan - metabolism | Plasmodium falciparum | Proteoglycans | Glycosaminoglycans | Malaria | Pregnant women | Immunoglobulin G | Fluorescence | Cross infection | Nosocomial infections | Chromatography | Protein binding | DBL, Duffy-binding-like | IE, infected erythrocyte | IEX, ion exchange | CSC, chondroitin sulphate C | HSPG, heparan sulphate proteoglycan | CSA, chondroitin sulphate A | PAM, pregnancy-associated malaria | GAG, glycosaminoglycan | CSPG, chondroitin sulphate proteoglycan | IMAC, immobilized metal ion affinity chromatography | AC, affinity chromatography | FV2, full-length VAR2CSA | PfEMP1, Plasmodium falciparum erythrocyte membrane protein 1 | CSPG-h, human chondroitin sulphate proteoglycan | MFI, mean fluorescence intensity | CSPG-b, bovine chondroitin sulphate proteoglycan
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1052 - 1062
Autophagy plays important roles in metabolism, differentiation, and survival in T cells. TNFAIP3/A20 is a ubiquitin-editing enzyme that is thought to be a... 
TNFAIP3 | CD4 | autophagy | MTOR | ubiquitin | ATG5 | Ubiquitin | Autophagy | receptor (TNFRSF)-interacting serine-threonine kinase 1 | BCL2-associated X protein | eukaryotic translation inhibition factor 4E binding protein 1 | DEATH | phosphate-buffered saline | proximity ligation assay | CD3E | ACTB | CELL BIOLOGY | CHX | PI3K | CD44 antigen | interleukin 2 | GROWTH | autophagy related | nuclear factor of kappa light polypeptide gene enhancer in B-cells | threonine kinase | LC3 | NF-KAPPA-B | PBS | MAMMALIAN TARGET | mean fluorescence intensity | polypeptide 1 | T cell receptor | killer 1 | lymphoma 2 | AMP-activated | CD3 antigen | NFKB | induced protein 3 | MAP1LC3 | actin | IFNG | mechanistic target of rapamycin (serine | TRAF6 | INFLAMMATION | ROS | DISEASE | BCL2-antagonist | AMPK | lipopolysaccharide | CD44 | A20 | v-akt murine thymoma viral oncogene homolog | TCR | 4-hydroxytamoxifen | PLA | ENZYME A20 | myeloid cell leukemia 1 | BCL10 | CD28 antigen | protein kinase | LPS | MALT1 | microtubule-associated protein 1 light chain 3 | CD69 antigen | MFI | class I phosphoinositide 3-kinase | reactive oxygen species | EIF4EBP1 | RIPK1 | BAK1 | B-cell CLL | epsilon polypeptide | ANTIGEN RECEPTOR | MCL1 | TNF receptor-associated factor 6 | lymphoma 10 | PRKAA | ESR | estrogen receptor | AKT | interferon | IL2 | 4-OHT | cycloheximide | E3 ubiquitin protein ligase | ATG | MALT1 paracaspase | RPS6KB1 | tumor necrosis factor | ribosomal protein S6 kinase | BCL2 | CD28 | BAX | CD69 | bACT | gamma | LYMPHOCYTES | TOR Serine-Threonine Kinases - metabolism | Cell Survival | CD4-Positive T-Lymphocytes - cytology | Humans | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | CD4-Positive T-Lymphocytes - ultrastructure | Intracellular Signaling Peptides and Proteins - metabolism | Receptors, Antigen, T-Cell | Intracellular Signaling Peptides and Proteins - deficiency | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | Cysteine Endopeptidases - metabolism | HEK293 Cells | Cysteine Endopeptidases - deficiency | Tumor Necrosis Factor alpha-Induced Protein 3 | Naphthyridines - pharmacology
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 09/2019, Volume 144, Issue 3, pp. 825 - 838
Thrombocytopenia is a serious issue for all patients with classical Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) because it causes severe... 
Wiskott-Aldrich syndrome | X-linked thrombocytopenia | gene therapy | platelets | CLEARANCE | CD40 LIGAND | CELL TRANSPLANTATION | SYNDROME PROTEIN | NEUTROPHILS | SPLENECTOMY | IMMUNOLOGY | ACTIVATED PLATELETS | ALLERGY | MUTATIONS | EXPRESSION | Genetic research | Care and treatment | Genetic aspects | Gene therapy | Analysis | Flow cytometry | Pediatrics | Transplants & implants | Medical services | Clinical trials | Agglomeration | Coexistence | Bleeding | Defects | Proteins | Genotype & phenotype | Signal transduction | Protein composition | Restoration | Blood platelets | Ultrastructure | Thrombocytopenia | Phenotypes | Immune reconstitution | Electron microscopy | Patients | Microscopy | Protein expression | Software | Mutation | Platelets | FERMT3, Fermitin family homolog 3 | TEM, Transmission electron microscopy | WAS, Wiskott-Aldrich syndrome | HMGB1, High-mobility group box 1 | δ-g, Electron-dense granule | GPX1, Glutathione peroxidase 1 | FU, Follow-up | sCD62P, Soluble P-selectin | sCD40L, Soluble CD40 ligand | BAFF, B cell–activating factor | CD62P, P-selectin | HSCT, Hematopoietic stem cell transplantation | WASp, Wiskott-Aldrich syndrome protein | MFI, Mean fluorescence intensity | LV, Lentivirus | CT, Closure time | GT, Gene therapy | OCS, Open canalicular system | PRP, Platelet-rich plasma | vWF, von Willebrand factor | STAT3, Signal transducer and activator of transcription 3 | HD, Healthy donor | ADP, Adenosine diphosphate | ROS, Reactive oxygen species | XLT, X-linked thrombocytopenia
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1063 - 1080
Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the... 
NQO2 | paraquat | astrocytes | parkinson disease | macroautophagy | ROS | Parkinson disease | Paraquat | Astrocytes | Macroautophagy | DMSO | autophagic vacuoles | 6 dihydro-6-phenyl | phosphate-buffered saline | CELL BIOLOGY | shRNA | short harpin ribonucleic acid | flow cytometry | NMDPEF | PBS | mean fluorescence intensity | antibody | 8-phenanthridinediamine | GLIAL INCLUSIONS | phosphorylated | MAPK | green fluorescent protein | Dulbecco's modified Eagle's medium | nuclear factor | CELL-DEATH | TRANSCRIPTION FACTOR NRF2 | small interfering ribonucleic acid | DISEASE | N-[2-(2-methoxy-6H-dipyrido[2,3-a:3,2-e]pyrrolizin-11-yl)ethyl]-2-furamide | glial fibrillary acidic protein | 1-methyl 4-phenyl 1 | erythroid 2-like 2 | room temperature | PROTEIN AGGREGATION | PHOSPHORYLATION | FACS | 5-carboxy-2 | chloroquine | GFP | mitogen-activated protein kinase | benzyldihydronicotinamide riboside | DMEM | MFI | IN-VITRO | dimethyl sulfoxide | reactive oxygen species | CA-DCF-DA | AVs | 5-(6-triphenylphosphoniumhexyl)-5 | substantia nigra | OXYGEN SPECIES PRODUCTION | 7 dichlorofluorescein diacetate | MitoSOX | siRNA | western blotting | BNAH | GFAP | 6-tetraidro-piridine | menadione | TTBS | NEURONS | MPTP | Tween-Tris buffered saline | oxidative stress | NFE2L2 | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Astrocytes - pathology | Astrocytes - enzymology | Vacuoles - drug effects | Autophagy - drug effects | Neuroprotection - drug effects | Astrocytoma - pathology | Neuroprotective Agents - pharmacology | Formamides - pharmacology | Phagosomes - drug effects | Astrocytes - drug effects | Quinone Reductases - metabolism | Parkinson Disease - pathology | Phagosomes - metabolism | Enzyme Inhibitors - pharmacology | Neurotoxins - toxicity | Antioxidants - pharmacology | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Acetylcysteine - pharmacology | Vacuoles - metabolism | Benzhydryl Compounds - pharmacology | Mice | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Paraquat - toxicity | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 2, pp. 482 - 490.e7
Background Mutations in the gene encoding filaggrin (FLG) , an epidermal structural protein, are the strongest risk factor identified for the development of... 
Allergy and Immunology | Langerhans cells | atopic dermatitis | Filaggrin | urocanic acid | costimulatory molecules | DENDRITIC CELLS | HUMAN SKIN | BARRIER | IMMUNOLOGY | SUPPRESSION | DELAYED-TYPE HYPERSENSITIVITY | HERPES-SIMPLEX VIRUS | ATOPIC-DERMATITIS | ALLERGY | DISEASE | EXPRESSION | CIS-UROCANIC ACID | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | Dermatitis, Atopic - genetics | Antigen-Presenting Cells - cytology | Coculture Techniques | Humans | Middle Aged | Male | T-Lymphocytes, Regulatory - immunology | CD11c Antigen - metabolism | Dermatitis, Atopic - diagnosis | Young Adult | Cell Differentiation - genetics | Flow Cytometry | Immunoglobulin E - immunology | Leukocytes, Mononuclear - immunology | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Langerhans Cells - immunology | Adult | Female | Epidermis - metabolism | Antigen-Presenting Cells - metabolism | Epidermis - pathology | Cell Communication | Antigen-Presenting Cells - immunology | Phenotype | Epidermis - immunology | Biomarkers | Leukocytes, Mononuclear - cytology | Mutation | Dermatitis, Atopic - metabolism | Langerhans Cells - metabolism | Langerhans Cells - cytology | Genetic aspects | Skin | Atopic dermatitis | Risk factors | Dendritic cells | Flow cytometry | Colleges & universities | Suctioning | Dermatitis | FACS, Fluorescence-activated cell sorting | AD, Atopic dermatitis | FLG, Filaggrin gene | LTA, Lipotechoic acid | MFI, Mean fluorescence intensity | IV, Ichthyosis vulgaris | PD-L1, Programmed death ligand 1 | TEWL, Transepidermal water loss | Atopic Dermatitis and Skin Disease | WT, Wild-type | LC, Langerhans cell | PE, Phycoerythrin | FITC, Fluorescein isothiocyanate | UCA, Urocanic acid | FoxP3, Forkhead box protein 3 | APC, Antigen-presenting cell | PerCP, Peridinin-chlorophyll-protein complex | SASSAD, Six Area, Six Sign Atopic Dermatitis Score | MDCC, Monocyte-derived dendritic cell
Journal Article