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Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2019, Volume 62, Issue 1, pp. 207 - 222
Two interesting new X-ray structures of negative allosteric modulator (NAM) ligands for the mGlu(5) receptor, M-MPEP (3) and fenobam (4), are reported. The new... 
TARGET | TRIAL | POTENT | CHEMISTRY, MEDICINAL | MGLU | DRUG DESIGN | OPPORTUNITIES | ANTAGONISTS | DRUGGABILITY | DERIVATIVES | DISCOVERY
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 1/2015, Volume 42, Issue 1, pp. 128 - 137
Journal Article
Neuron, ISSN 0896-6273, 05/2017, Volume 94, Issue 3, pp. 431 - 446
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 639, Issue 1, pp. 40 - 46
The NMDA (N-methyl- -aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the... 
Positive allosteric modulator | mGlu 5 receptor | Metabotropic glutamate receptor 5 | ADX-47273 | Long-term potentiation | NMDA(N-methyl- D-aspartate)-receptor | receptor | MGlu | NMDA(N-methyl-D-aspartate)-receptor | GLUTAMATE-RECEPTOR-5 | ACTIVATION | SYNAPTIC-TRANSMISSION | HIPPOCAMPAL CA1 REGION | AREA CA1 | IN-VITRO | SLICES | POTENTIATION | LONG-TERM DEPRESSION | MGLUR5 | PHARMACOLOGY & PHARMACY | NMDA(N-methyl-D-aspartate)-receptor mGlu receptor | Oxadiazoles - administration & dosage | Phosphorylation | Rats, Wistar | Calcium - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Dose-Response Relationship, Drug | Allosteric Regulation - physiology | Piperidines - pharmacology | Oxadiazoles - pharmacology | src-Family Kinases - metabolism | Cognition - physiology | Receptor, Metabotropic Glutamate 5 | Neurons - metabolism | Neurons - drug effects | Allosteric Regulation - drug effects | Piperidines - administration & dosage | Pyridines - administration & dosage | Injections, Intraperitoneal | Rats | Excitatory Amino Acid Agonists - pharmacology | Cognition - drug effects | Hippocampus - cytology | Excitatory Amino Acid Agonists - administration & dosage | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Pyridines - pharmacology | Methoxyhydroxyphenylglycol - administration & dosage | Receptors, Metabotropic Glutamate - agonists
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 603, Issue 1, pp. 62 - 72
Journal Article