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Journal of Neuroscience, ISSN 0270-6474, 07/2009, Volume 29, Issue 29, pp. 9301 - 9313
Members of the R7 family of the Regulators of G protein signaling (R7 RGS) proteins form multi-subunit complexes that play crucial roles in processing the... 
signal transduction | retina | RGS proteins | intracellular targeting | ON-bipolar neurons | mGluR6 | G protein
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2012, Volume 32, Issue 33, pp. 11343 - 11355
Heterotrimeric G-proteins, comprising G alpha and G beta gamma subunits, couple metabotropic receptors to various downstream effectors and contribute to... 
CONE PHOTORECEPTORS | SPLICE VARIANT | SLOWED RECOVERY | ON-BIPOLAR CELLS | MOUSE RETINA | HETEROTRIMERIC-G-PROTEINS | DRIVEN RETINAL RESPONSES | GAMMA-SUBUNIT | BETA-SUBUNIT | NEUROSCIENCES | RECEPTOR MGLUR6
Journal Article
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 03/2017, Volume 58, Issue 3, pp. 1768 - 1778
PURPOSE. Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). Using a cCSNB mouse model lacking Lrit3 (nob6), we recently have... 
Retina | Congenital stationary night blindness | Multielectrode array | Electron microscopy | LRIT3 | METABOTROPIC GLUTAMATE-RECEPTOR | PHOTORECEPTOR SYNAPSES | congenital stationary night blindness | OUTER PLEXIFORM LAYER | MAMMALIAN RETINA | RETINAL GANGLION-CELLS | multielectrode array | retina | MGLUR6 | OPHTHALMOLOGY | electron microscopy | MOUSE RETINA | NORMAL LIGHT | STATIONARY NIGHT BLINDNESS | VISUAL RESPONSES | Immunohistochemistry | Synaptic Transmission - genetics | Night Blindness - metabolism | Humans | Male | Dendrites - ultrastructure | Retinal Cone Photoreceptor Cells - ultrastructure | Myopia - metabolism | Young Adult | Synapses - metabolism | DNA Mutational Analysis | Night Blindness - pathology | Female | Genetic Diseases, X-Linked - genetics | Membrane Proteins - metabolism | Retrospective Studies | Night Blindness - genetics | Electroretinography | Dendrites - metabolism | Retinal Bipolar Cells - metabolism | Eye Diseases, Hereditary - pathology | Membrane Proteins - genetics | Myopia - pathology | Synapses - ultrastructure | Genetic Diseases, X-Linked - metabolism | Microscopy, Electron | Eye Diseases, Hereditary - genetics | Mice, Knockout | DNA - genetics | Myopia - genetics | Animals | Retinal Bipolar Cells - ultrastructure | Genetic Diseases, X-Linked - pathology | Mice | Mutation | Retinal Cone Photoreceptor Cells - metabolism | Eye Diseases, Hereditary - metabolism | Index Medicus | Life Sciences | Human health and pathology | Sensory Organs | Visual Neuroscience
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 02/2016, Volume 6
Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic... 
PHOSDUCIN | ACTIVATED K+ CHANNEL | LIGHT RESPONSE | SPLICE VARIANT | MULTIDISCIPLINARY SCIENCES | METABOTROPIC RECEPTOR MGLUR6 | ROD BIPOLAR | HETEROTRIMERIC-G-PROTEINS | BINDING | MODULATION | STATIONARY NIGHT BLINDNESS
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 01/2013, Volume 92, Issue 1, pp. 67 - 75
Journal Article
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 05/1998, Volume 395, Issue 1, pp. 43 - 52
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2009, Volume 29, Issue 19, pp. 6088 - 6093
On bipolar cells are connected to photoreceptors via a sign-inverting synapse. At this synapse, glutamate binds to a metabotropic receptor which couples to the... 
CAPSAICIN RECEPTOR | RETINAL GANGLION-CELLS | METABOTROPIC GLUTAMATE-RECEPTOR | PATHWAY | DESENSITIZATION | MGLUR6 | MOUSE | TRP CHANNELS | G-PROTEIN | NEUROSCIENCES | STATIONARY NIGHT BLINDNESS | Propionates - pharmacology | Transient Receptor Potential Channels - antagonists & inhibitors | Synaptic Transmission - physiology | Capsaicin - pharmacology | Receptors, Metabotropic Glutamate - metabolism | Amino Acids - pharmacology | TRPV Cation Channels - metabolism | Retinal Bipolar Cells - physiology | TRPV Cation Channels - antagonists & inhibitors | Synaptic Transmission - drug effects | Ruthenium Red - metabolism | Transient Receptor Potential Channels - metabolism | Endocannabinoids | Xanthenes - pharmacology | Membrane Potentials - drug effects | Mice, Inbred C57BL | TRPV Cation Channels - agonists | TRPM Cation Channels - agonists | Capsaicin - analogs & derivatives | Excitatory Amino Acid Antagonists - pharmacology | Membrane Potentials - physiology | Cinnamates - pharmacology | Transient Receptor Potential Channels - agonists | Arachidonic Acids - pharmacology | Mice, Knockout | Animals | TRPM Cation Channels - antagonists & inhibitors | Anilides - pharmacology | Polyunsaturated Alkamides - pharmacology | Glutamic Acid - metabolism | Mice | TRPM Cation Channels - metabolism | Receptors, Metabotropic Glutamate - agonists | Index Medicus | Retina | TRPV | Patch Clamp | metabotropic glutamate receptor | Capsaicin | Knockout
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 06/2019, Volume 83, Issue 6, pp. 1027 - 1034
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 02/2012, Volume 90, Issue 2, pp. 331 - 339
Complete congenital stationary night blindness (cCSNB) is a clinically and genetically heterogeneous group of retinal disorders characterized by nonprogressive... 
COMPLETE FORM | LIGHT RESPONSE | CHANNEL | MGLUR6 | SYNAPTIC-TRANSMISSION | MOUSE MODEL | GENETICS & HEREDITY | NYCTALOPIN | RICH REPEAT PROTEIN | MUTATIONS | CONE ELECTRORETINOGRAM | Electroretinography - methods | Night Blindness - metabolism | Humans | Dark Adaptation - genetics | Retinal Rod Photoreceptor Cells - metabolism | Gene Knockdown Techniques - methods | Myopia - metabolism | Receptors, Metabotropic Glutamate - genetics | Retinal Bipolar Cells - physiology | Chromosome Mapping - methods | Genetic Diseases, X-Linked | Night Blindness - genetics | Retinal Bipolar Cells - metabolism | Eye Diseases, Hereditary | Signal Transduction | Mice, Inbred C57BL | Zebrafish | Mice, Inbred C3H | Myopia - genetics | Animals | Myopia - physiopathology | Pedigree | Night Blindness - physiopathology | Retinal Rod Photoreceptor Cells - physiology | Heterozygote | Mice | Receptors, G-Protein-Coupled - genetics | Mutation | Chromosome mapping | Usage | Gene mutations | Retinal bipolar cells | Causes of | Physiological aspects | Night blindness | Genetic aspects | Research | Analysis | Genetic disorders | Proteins | Rodents | Blindness | Gene expression | Cells | Index Medicus | Animal models | Antibodies | Insertion | stationary night blindness | Retina | Guanine nucleotide-binding protein | Electroretinograms | Depolarization | Signal transduction | Vision | Bipolar cells | Gene mapping | DNA sequencing | Report
Journal Article
Journal Article