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Annals of Surgical Oncology, ISSN 1068-9265, 4/2014, Volume 21, Issue 4, pp. 1337 - 1344
Journal Article
Archives of Medical Science, ISSN 1734-1922, 2019, Volume 15, Issue 2, pp. 504 - 512
Introduction: TP53 and MGMT alterations play a crucial role in glioblastoma (GB) pathogenesis. TP53 and MGMT function is affected by several pathologic... 
MicroRNA | MGMT | TP53 | O6-methylguanine-DNA methyltransferase | SURVIVAL | PROTEIN | PROGNOSTIC-FACTORS | SOLID TUMORS | PROMOTER METHYLATION | CLASSIFICATION | ADJUVANT TEMOZOLOMIDE | MEDICINE, GENERAL & INTERNAL | P53 GENE | CONCOMITANT | microRNA | ACCUMULATION | Mutation | Basic Research | GB
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2014, Volume 15, Issue 24, pp. 10893 - 10898
Several molecular markers have been proposed as predictors of outcome in patients with glioblastomas. We investigated the prognostic significance of... 
IDH1 mutation | Glioblastomas | MGMT promoter methylation | Prognosis | TP53 mutation | ASTROCYTOMA | SURVIVAL | HYPERMETHYLATION | INTEGRATED GENOMIC ANALYSIS | PREDICTIVE-VALUE | prognosis | TEMOZOLOMIDE | K-RAS | ONCOLOGY | HIGH-GRADE GLIOMAS | EXPRESSION | GENETIC ALTERATIONS
Journal Article
by Wang, X and Chen, JX and Liu, YH and You, C and Mao, Q
NEUROLOGICAL SCIENCES, ISSN 1590-1874, 08/2013, Volume 34, Issue 8, pp. 1421 - 1428
The "gain of function" of mutant TP53 is an important determinant in human tumor development and progression. This study aimed to investigate the possible... 
GLIOMA-CELLS | RNA interference | MGMT | Glioblastoma | PHASE-III | DOWN-REGULATION | Drug resistance | Tumor suppressor protein p53 | NEUROSCIENCES | CHEMOTHERAPY | CLINICAL NEUROLOGY | GENE | P53 MUTANTS | Mutation | EXPRESSION | HUMAN CANCER | GAIN
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 02/2011, Volume 101, Issue 3, pp. 405 - 417
Journal Article
INTERNATIONAL JOURNAL OF CANCER, ISSN 0020-7136, 02/2005, Volume 113, Issue 4, pp. 581 - 587
Epigenetic silencing of O-6-methylguanine-DNA methyltransferase (MGMT) by promoter methylation can confer cancer cells with an increased sensitivity to... 
SURVIVAL | glioblastoma multiforme | PROMOTER HYPERMETHYLATION | TUMOR-SUPPRESSOR GENE | COLORECTAL TUMORIGENESIS | chemotherapy | TP53 mutation | GRADE DIFFUSE ASTROCYTOMAS | P53 MUTATIONS | INACTIVATION | GLIOBLASTOMA | MGMT methylation | K-RAS | ONCOLOGY | anaplastic astrocytoma | DNA-REPAIR GENE
Journal Article
Brain, ISSN 0006-8950, 10/2007, Volume 130, Issue 10, pp. 2596 - 2606
Journal Article
Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko, ISSN 0042-8817, 2017, Volume 81, Issue 6, pp. 26 - 31
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 50, pp. 87554 - 87567
Rationale: Glioma has a poor survival rate in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for treating... 
Glioma | TP53 | Temozolomide | temozolomide | PATHWAYS | APOPTOSIS | MGMT | PTEN | RISK | CELL BIOLOGY | MALIGNANT GLIOMA | GLIOBLASTOMA | CANCER GENOMICS | THERAPY | LOW-GRADE GLIOMA | glioma
Journal Article
Cancer Journal (United States), ISSN 1528-9117, 2014, Volume 20, Issue 1, pp. 66 - 72
Journal Article
Journal Article
Journal Article
Journal Article
Neuro-Oncology, ISSN 1522-8517, 02/2011, Volume 13, Issue 2, pp. 235 - 241
textabstractOnly a few studies examined the effect of temozolomide (TMZ) in recurrent low-grade astrocytoma (LGA) after surgery, none of which included a... 
Chemotherapy | Glioma | Low-grade astrocytoma | MGMT | Brain tumors | IDH1 | IDH2 | 19q | Temozolomide | TP53 | Trisomy 7 | temozolomide | SURVIVAL | PROMOTER HYPERMETHYLATION | IDH2 MUTATIONS | trisomy 7 | chemotherapy | CLINICAL NEUROLOGY | PHASE-II TRIAL | brain tumors | ONCOLOGY | ANAPLASTIC OLIGODENDROGLIAL TUMORS | low-grade astrocytoma | glioma | EUROPEAN-ORGANIZATION | REPAIR GENE | O-6-METHYLGUANINE DNA METHYLTRANSFERASE | Astrocytoma - radiotherapy | Trisomy | Follow-Up Studies | Dacarbazine - therapeutic use | Humans | Middle Aged | Male | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | Tumor Suppressor Protein p53 - genetics | Chromosomes, Human, Pair 19 - genetics | DNA Methylation | Astrocytoma - drug therapy | Dacarbazine - analogs & derivatives | Polymerase Chain Reaction | Adult | Female | Brain Neoplasms - radiotherapy | Chromosomes, Human, Pair 1 - genetics | Astrocytoma - genetics | Chromosome Deletion | Radiotherapy Dosage | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Survival Rate | Treatment Outcome | Brain Neoplasms - drug therapy | Mutation - genetics | Antineoplastic Agents, Alkylating - therapeutic use | O-Methylguanine-DNA Methyltransferase - genetics | Biomarkers, Tumor - genetics | DNA, Neoplasm - genetics | Neoplasm Staging | Clinical Investigations
Journal Article