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Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 1, pp. 65 - 75
Tyrosine kinases are aberrantly activated in numerous malignancies, including acute myeloid leukemia (AML). To identify tyrosine kinases activated in AML, we... 
CELLCYCLE | ALLOGRAFT-REJECTION | POLYCYTHEMIA-VERA | MYELOPROLIFERATIVE DISORDERS | ONCOLOGY | CONSTITUTIVE ACTIVATION | TYROSINE KINASE JAK2 | PSEUDOKINASE DOMAIN | ACUTE MYELOID-LEUKEMIA | JANUS KINASE | CELL-LINES | MICE LACKING JAK3 | CELL BIOLOGY | RNA, Small Interfering - genetics | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | TYK2 Kinase | Janus Kinase 2 | Janus Kinase 3 | Protein-Tyrosine Kinases - genetics | Leukemia, Megakaryoblastic, Acute - genetics | Phosphorylation - drug effects | Leukemia, Megakaryoblastic, Acute - metabolism | Leukemia, Experimental - genetics | Leukemia, Experimental - pathology | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Mice, Inbred C57BL | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Animals | Mutant Proteins - chemistry | Alleles | K562 Cells | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Benzamides | Leukemia, Megakaryoblastic, Acute - pathology | Leukemia, Experimental - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Allelomorphism | Proteins | Analysis | Oncology, Experimental | Research | Mass spectrometry | Phosphotransferases | Cancer
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2011, Volume 585, Issue 1, pp. 159 - 166
Journal Article
British Journal of Haematology, ISSN 0007-1048, 01/2010, Volume 148, Issue 1, pp. 132 - 143
Summary In order to identify Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling inhibitors, a cell-based high throughput... 
cell-based high throughput screening | cancer | Janus kinase/signal transducer and activator of transcription | plant extracts | small molecule inhibitor | cell‐based high throughput screening | Cell-based high throughput screening | Small molecule inhibitor | Cancer | Plant extracts | SURVIVIN EXPRESSION | MYELOPROLIFERATIVE NEOPLASMS | signal transducer and activator of transcription | SIGNAL-TRANSDUCTION | JAK/STAT PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | ACUTE MEGAKARYOBLASTIC LEUKEMIA | TYROSINE KINASE JAK2 | Janus kinase | HEMATOLOGY | TRANSCRIPTION FACTOR | MICE LACKING JAK3 | Chromatography, High Pressure Liquid - methods | Apoptosis - drug effects | Hodgkin Disease - pathology | Plant Extracts - pharmacology | Humans | Serotonin - pharmacology | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Janus Kinase 3 - antagonists & inhibitors | STAT Transcription Factors | T-Lymphocytes - drug effects | Tumor Cells, Cultured | Janus Kinase 3 - metabolism | STAT3 Transcription Factor - metabolism | Cell Line | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Hodgkin Disease - metabolism | Drosophila | Naphthols - pharmacology | Rats | Animals | Signal Transduction - drug effects | Breast Neoplasms - pathology | Interleukin-2 - pharmacology | Serotonin - analogs & derivatives | Protein Kinase Inhibitors - pharmacology | Gene expression | Biological products | STAT | JAK
Journal Article
BLOOD, ISSN 0006-4971, 02/2011, Volume 117, Issue 6, pp. 1938 - 1946
Journal Article
Blood, ISSN 0006-4971, 03/2009, Volume 113, Issue 12, pp. 2746 - 2754
Journal Article