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Journal Article
Physiology, ISSN 1548-9213, 04/2009, Volume 24, Issue 2, pp. 97 - 106
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 04/2008, Volume 15, Issue 4, pp. 621 - 627
The increase in body size of humans and other vertebrates requires a physiological infrastructure to provide adequate delivery of oxygen to tissues and cells... 
hypoxia | transcription factor | MICE PARTIALLY DEFICIENT | TRANSCRIPTIONAL ACTIVITY | HIF | PROLYL HYDROXYLATION | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA-INDUCIBLE-FACTOR | PHD | HIPPEL-LINDAU PROTEIN | FACTOR-ALPHA | CELL BIOLOGY | FACTOR 1-ALPHA | GENE-EXPRESSION | TUMOR-SUPPRESSOR PROTEIN | TRANSACTIVATION DOMAIN | VHL | oxygen
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 11/2006, Volume 70, Issue 5, pp. 1469 - 1480
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2008, Volume 217, Issue 3, pp. 674 - 685
Sleep‐disordered breathing with recurrent apnea (periodic cessation of breathing) results in chronic intermittent hypoxia (IH), which leads to cardiovascular... 
MICE PARTIALLY DEFICIENT | RESPONSES | OXIDATIVE STRESS | PHYSIOLOGY | INDUCIBLE FACTOR 1-ALPHA | PROLINE HYDROXYLATION | LONG-TERM FACILITATION | SLEEP-APNEA | CAROTID-BODY | PC12 CELLS | HIF-ALPHA | CELL BIOLOGY | Intermittent hypoxia | Calcium signaling | mTOR | HIF-1α | Prolyl hydroxylases | NADPH oxidase
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 02/2014, Volume 189, Issue 3, pp. 314 - 324
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 117, Issue 7, pp. 941 - 952
Hypoxia-inducible factor-1α (HIF1α) is a central regulator of the cellular response to hypoxia. Prolyl-hydroxylation of HIF1α by PHD enzymes is prerequisite... 
MICE PARTIALLY DEFICIENT | MAMMALIAN HOMOLOGS | OXYGEN-TENSION | INDUCIBLE FACTOR 1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR | GROWTH-FACTOR | HIF-1-ALPHA | O-2 TENSION | HIF-ALPHA | UBIQUITIN-PROTEASOME PATHWAY | CELL BIOLOGY | Ubiquitin | Hypoxia | Research | Gene expression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 7, pp. 3065 - 3070
Cardiorespiratory functions in mammals are exquisitely sensitive to changes in arterial O₂ levels. Hypoxia-inducible factors (e.g., HIF-1 and HIF-2) mediate... 
Antioxidants | Oxidative stress | Apnea | Messenger RNA | Hypoxia | Mice | Breathing | Carotid body | Endothelial cells | Genotypes | blood pressure | catecholamines | OXIDATIVE STRESS | HOMEOSTASIS | MULTIDISCIPLINARY SCIENCES | BLOOD-PRESSURE | FACTOR 1-ALPHA | RESPONSES | INTERMITTENT HYPOXIA | PARTIALLY DEFICIENT | NULL MICE | control of ventilation | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
JOURNAL OF APPLIED PHYSIOLOGY, ISSN 8750-7587, 03/2004, Volume 96, Issue 3, pp. 1173 - 1177
The cardiovascular and respiratory systems play key roles in O-2 homeostasis. Physiological responses to hypoxia involve changes in gene expression that are... 
hypoxia | MICE PARTIALLY DEFICIENT | SPORT SCIENCES | PHYSIOLOGY | INDUCIBLE FACTOR-I | PULMONARY-HYPERTENSION | RAT | pulmonary hypertension | hypoxia-inducible factor | PREVENTS | ISCHEMIA-REPERFUSION INJURY | FACTOR 1-ALPHA | RESPONSES | CHRONIC HYPOXIA | erythropoietin
Journal Article