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1. Full Text An Integrated Microreactor System for Self‐Optimization of a Heck Reaction: From Micro‐ to Mesoscale Flow Systems
by McMullen, Jonathan P and Stone, Matthew T and Buchwald, Stephen L and Jensen, Klavs F
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2010, Volume 49, Issue 39, pp. 7076 - 7080
Set it and forget it: The combination of feedback control and continuous‐flow operations in microreactors (see picture) enables online and fully automated... 
palladium | arenes | microreactors | synthetic methods | CC coupling | C-C coupling | Arenes | Palladium | Synthetic methods | Microreactors | ORGANIC-SYNTHESIS | CATALYSIS | LIQUID | CHEMISTRY, MULTIDISCIPLINARY | Microfluidic Analytical Techniques - methods | Automation | Furans - chemistry | Microfluidic Analytical Techniques - instrumentation | Fluorobenzenes - chemistry | Miniaturization | Palladium - chemistry | Carbon - chemistry
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2. Full Text Organ‐on‐a‐Chip Systems: Microengineering to Biomimic Living Systems
by Zheng, Fuyin and Fu, Fanfan and Cheng, Yao and Wang, Chunyan and Zhao, Yuanjin and Gu, Zhongze
Small, ISSN 1613-6810, 05/2016, Volume 12, Issue 17, pp. 2253 - 2282
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully,... 
organ‐on‐a‐chip | human‐on‐a chip | biomaterials | biomimics | microfluidics | organ-on-a-chip | human-on-a chip | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | DRUG-INDUCED NEPHROTOXICITY | NEUROVASCULAR UNIT | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | OF-THE-ART | BARCODE PARTICLES | PLURIPOTENT STEM-CELLS | TUMOR SPHEROIDS | IN-VITRO MODEL | ENDOTHELIAL-CELLS | MICROFLUIDIC CULTURE PLATFORM | Biomedical Engineering | Animals | Biomimetics | Models, Biological | Humans | Microfluidic Analytical Techniques - instrumentation | Cell Membrane Permeability | Artificial Organs | Blood-Brain Barrier | Microfluidics | Biological products | Index Medicus | Human | Design engineering | Platforms | Reproduction | Microengineering | Organs | Mathematical models | Physiology
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3. Full Text Integrated lab-on-chip biosensing systems based on magnetic particle actuation - a comprehensive review
by van Reenen, Alexander and de Jong, Arthur M and den Toonder, Jaap M. J and Prins, Menno W. J
Lab on a Chip, ISSN 1473-0197, 5/2014, Volume 14, Issue 12, pp. 1966 - 1986
The demand for easy to use and cost effective medical technologies inspires scientists to develop innovative lab-on-chip technologies for point-of-care in... 
PROTEIN-DETECTION | CHEMISTRY, ANALYTICAL | ROTATING CAPILLARY-TUBE | BIOCHEMICAL RESEARCH METHODS | SUPRAPARTICLE STRUCTURES | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | MICROFLUIDIC PLATFORM | BEADS | PURIFICATION | FORCE DIFFERENTIATION | DYNAMICS | PARAMAGNETIC PARTICLES | IMMUNOASSAY | Biosensing Techniques - instrumentation | Biosensing Techniques - methods | Lab-On-A-Chip Devices | Magnetic Fields
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4. Full Text Active pharmaceutical ingredient (API) production involving continuous processes – A process system engineering (PSE)-assisted design framework
by Cervera-Padrell, Albert E and Skovby, Tommy and Kiil, Søren and Gani, Rafiqul and Gernaey, Krist V
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 10/2012, Volume 82, Issue 2, pp. 437 - 456
Workflow of the systematic design framework for the development of API manufacturing processes involving continuous processes. A systematic framework is... 
Continuous pharmaceutical manufacturing | Active pharmaceutical ingredient | Continuous processes | Methodology | Design framework | Microfluidic | INDUSTRY | PERSPECTIVE | SOLVENT SELECTION | REVOLUTION | PROCESS INTENSIFICATION | MICROREACTOR TECHNOLOGY | MANUFACTURING PROCESS | DISTILLATION | PHARMACOLOGY & PHARMACY | OPTIMIZATION | REACTOR NETWORKS | Drug Discovery - methods | Technology, Pharmaceutical - methods | Fermentation | Drug Industry - methods | Solvents - chemistry | Pharmaceutical Preparations - chemistry | Microfluidics
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5. Full Text A Fully Integrated Microfluidic Genetic Analysis System with Sample-In-Answer-Out Capability
by Christopher J. Easley and James M. Karlinsey and Joan M. Bienvenue and Lindsay A. Legendre and Michael G. Roper and Sanford H. Feldman and Molly A. Hughes and Erik L. Hewlett and Tod J. Merkel and Jerome P. Ferrance and James P. Landers
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, pp. 19272 - 19277
We describe a microfluidic genetic analysis system that represents a previously undescribed integrated microfluidic device capable of accepting whole blood as... 
Polymerase chain reaction | Integrated circuits | Forensic genetics | DNA | Medical genetics | Reagents | Extraction | Nucleic acids | Blood | Whooping cough | Full integration | Micro total analysis system | Valving | Pumping | Microdevice | microdevice | CHEMICAL-ANALYSIS SYSTEMS | valving | PRESSURE INJECTION | CELL-LYSIS | MULTIDISCIPLINARY SCIENCES | DNA AMPLIFICATION | DEVICE | micro total analysis system | pumping | GLASS | POLYMERASE-CHAIN-REACTION | ELECTROPHORESIS | BORDETELLA-PERTUSSIS | full integration | PCR | Microfluidic Analytical Techniques - methods | DNA - isolation & purification | Genetic Techniques | Electrophoresis, Microchip - methods | Microfluidic Analytical Techniques - instrumentation | Polymerase Chain Reaction - methods | Heart valves | Design and construction | Biological Sciences
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6. Full Text Microfluidic immunosensor systems
by Bange, Adam and Halsall, H. Brian and Heineman, William R
Biosensors and Bioelectronics, ISSN 0956-5663, 2005, Volume 20, Issue 12, pp. 2488 - 2503
Immunosensing microfluidic devices are reviewed. Devices are commonly fabricated in glass, silicon, and polymers, with polymers seeing greater attention in... 
Immunoassay | Antibody | Immunosensor | Microfluidic | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | antibody | FLUORESCENCE POLARIZATION | ENZYME-IMMUNOASSAY | LINKED-IMMUNOSORBENT-ASSAY | ELECTROPHORESIS-BASED IMMUNOASSAY | NANOSCIENCE & NANOTECHNOLOGY | HOMOGENEOUS IMMUNOASSAY | immunoassay | WHOLE-BLOOD | INTERDIGITATED ARRAY ELECTRODES | ELECTROCHEMICAL DETECTION | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | immunosensor | CAPILLARY-ELECTROPHORESIS | microfluidic | FIBER-OPTIC BIOSENSOR | Microfluidic Analytical Techniques - methods | Spectrometry, Fluorescence - methods | Immunoassay - instrumentation | Microfluidic Analytical Techniques - instrumentation | Equipment Design | Microfluidic Analytical Techniques - trends | Flow Injection Analysis - trends | Spectrometry, Fluorescence - trends | Spectrometry, Fluorescence - instrumentation | Flow Injection Analysis - instrumentation | Immunoassay - methods | Immunoassay - trends | Biosensing Techniques - instrumentation | Biosensing Techniques - methods | Flow Injection Analysis - methods | Biosensing Techniques - trends | Electrochemistry - methods | Electrochemistry - instrumentation | Electrochemistry - trends | Electrochemistry | Electrochemical reactions | Analysis
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7. Full Text Integrated Microfluidic System for Rapid DNA Fingerprint Analysis: A Miniaturized Integrated DNA Analysis System (MiDAS)-Swab Sample-In to DNA Profile-Out
by Yang, Jianing and Yang, Jianing and Hurth, Cedric and Hurth, Cedric and Nordquist, Alan and Nordquist, Alan and Smith, Stan and Smith, Stan and Zenhausern, Frederic and Zenhausern, Frederic
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1906, pp. 207 - 224
A fully automated rapid DNA analysis system requires integrating several operational elements performing multiple steps onto one single microfluidic platform.... 
DNA extraction | Integration | Multiplexed PCR | STR analysis | Capillary electrophoresis | Microfluidics | Microfluidic Analytical Techniques - methods | Specimen Handling | Electrophoresis, Capillary | DNA Fingerprinting - instrumentation | Humans | Microfluidic Analytical Techniques - instrumentation | Forensic Genetics | Mouth - chemistry | Multiplex Polymerase Chain Reaction | Equipment Design | DNA Fingerprinting - methods | Microsatellite Repeats
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8. Full Text Latest developments in micro total analysis systems
by Arora, Arun and Simone, Giuseppina and Salieb-Beugelaar, Georgette B and Kim, Jung Tae and Manz, Andreas
Analytical Chemistry, ISSN 0003-2700, 06/2010, Volume 82, Issue 12, pp. 4830 - 4847
ON-A-CHIP | CHEMISTRY, ANALYTICAL | POROUS POLYMER MONOLITHS | POLY(METHYL METHACRYLATE) | ELECTROCHEMICAL DETECTION | SINGLE-MOLECULE | CAPILLARY-ELECTROPHORESIS | ULTRASENSITIVE DETECTION | ENHANCED RAMAN-SCATTERING | MICROFLUIDIC PERFUSION SYSTEM | REAL-TIME
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9. Full Text Reconfigurable system for automated optimization of diverse chemical reactions
by Bédard, Anne-Catherine and Adamo, Andrea and Aroh, Kosi C and Russell, M. Grace and Bedermann, Aaron A and Torosian, Jeremy and Yue, Brian and Jensen, Klavs F and Jamison, Timothy F
Science, ISSN 0036-8075, 09/2018, Volume 361, Issue 6408, pp. 1220 - 1225
Chemical synthesis generally requires labor-intensive, sometimes tedious trial-and-error optimization of reaction conditions. Here, we describe a... 
PLATFORM | ORGANIC-SYNTHESIS | VISIBLE-LIGHT | CATALYSIS | SELF-OPTIMIZATION | PHOTOREDOX | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | MICROFLUIDIC SYSTEM | CONTINUOUS-FLOW | MOLECULES | Technology application | Chemical synthesis | Analysis | Methods | Chemical research | Chemical tests and reagents | Substitution reactions | Catalysis | Mass spectrometry | High performance liquid chromatography | Downloading | Photochemicals | Optimization | Smartphones | Reactors | Amination | Mathematical analysis | Chemists | Inert atmospheres | Reconfigurable control systems | Carbon-carbon composites | Cross coupling | Automation | Chemical reactions | Mass spectroscopy | Palladium | Liquid chromatography | Separators | High-performance liquid chromatography | Analytics | Computer programs | Intermediates | Organic chemistry | Reagents | Graphical user interface | Software | Remote monitoring
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10. Full Text Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems
by Modena, Mario M and Chawla, Ketki and Misun, Patrick M and Hierlemann, Andreas
ACS Chemical Biology, ISSN 1554-8929, 07/2018, Volume 13, Issue 7, pp. 1767 - 1784
Technological advances in microfabrication techniques in combination with organotypic cell and tissue models have enabled the realization of microphysiological... 
LABEL-FREE | MICROFLUIDIC DEVICE | QUARTZ-CRYSTAL-MICROBALANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO MODEL | ELECTRICAL-IMPEDANCE SPECTROSCOPY | OPTICAL OXYGEN SENSORS | MULTIANALYTE MICROPHYSIOMETRY | SURFACE-PLASMON RESONANCE | ELECTROCHEMICAL IMMUNOSENSORS | REAL-TIME | High-Throughput Screening: Methods commonly applied in drug discovery for the rapid screening of large libraries of compounds, and usually based on the automation of the analysis procedure | Body-on-Chip: Combination of multiple interconnected organotypic model tissues on a test platform | Microfluidics: Science and technology of fluids in sub-millimeter scale regimes | Integrated Sensors: Sensors installed and operated within a cell-culture platform | Acoustic-Wave Sensors and Actuators: Devices based on the generation of acoustic waves in piezoelectric materials for sensing and actuation applications | Microphysiological Systems: Model systems able to recapitulate aspects of human physiology in vitro | Electrical Impedance Spectroscopy: Method to measure the dielectric properties of samples | Electrochemical Biosensors: Sensors that produce an electrical signal proportional to the analyte concentration
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11. Full Text Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair
by Jung, Hosung and Yoon, Byung C and Holt, Christine E
Nature Reviews Neuroscience, ISSN 1471-003X, 05/2012, Volume 13, Issue 5, pp. 308 - 324
mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based... 
RETINAL GROWTH CONES | BETA-ACTIN SYNTHESIS | ATROPHY-DETERMINING GENE | FRAGILE-X-SYNDROME | SYMPATHETIC NEURONS | MICROFLUIDIC CULTURE PLATFORM | MOTOR-NEURON SMN | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | KAPPA-OPIOID-RECEPTOR | SQUID GIANT-AXON | RNA, Messenger - biosynthesis | Animals | Axons - pathology | Humans | RNA, Messenger - genetics | Axons - metabolism | Cell Survival - genetics | Nervous System Diseases - metabolism | Axons - physiology | Protein Biosynthesis - genetics | Nervous System Diseases - genetics | Nervous System Diseases - pathology
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