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Genes and Development, ISSN 0890-9369, 12/2012, Volume 26, Issue 23, pp. 2647 - 2658
Journal Article
Clinical and Experimental Dermatology, ISSN 0307-6938, 10/2018, Volume 43, Issue 7, pp. 860 - 862
Click here for the corresponding questions to this CME article. 
DERMATOLOGY | Skin | Microphthalmia
Journal Article
Oncogene, ISSN 0950-9232, 05/2012, Volume 31, Issue 19, pp. 2461 - 2470
Melanomas are very aggressive neoplasms with notorious resistance to therapeutics. It was recently proposed that the remarkable phenotypic plasticity of... 
hypoxia | mesenchymal transition | MITF | differentiation | metastasis | Bhlhb2 | STEM-CELLS | SPARC | BIOCHEMISTRY & MOLECULAR BIOLOGY | LESS-THAN-OR-EQUAL-TO-1 MM | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | DEC1 | IN-VITRO | ONCOLOGY | GROWTH | GENETICS & HEREDITY | GENE-EXPRESSION | CYCLE PROGRESSION | Melanoma - metabolism | Skin Neoplasms - pathology | Basic Helix-Loop-Helix Transcription Factors - genetics | Microphthalmia-Associated Transcription Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neoplasm Invasiveness | Humans | Gene Silencing | Melanoma, Experimental - metabolism | Melanoma - secondary | Microphthalmia-Associated Transcription Factor - antagonists & inhibitors | Skin Neoplasms - metabolism | Cell Hypoxia | Neoplasm Metastasis | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Melanoma, Experimental - secondary | Mesoderm - metabolism | Mice | Mesoderm - pathology | Microphthalmia-Associated Transcription Factor - genetics | Usage | Animal models in research | Stem cells | Melanoma | Development and progression | Genetic aspects | Research | Metastasis | Health aspects | Risk factors | Genotype & phenotype | Hypoxia | Oncology | Cellular biology | Skin cancer | Index Medicus | Microphthalmia-associated transcription factor | Hypoxia-inducible factor 1 | Mesenchyme | Invasiveness | Mortality | Melanocytes | phenotypic plasticity | Drug development | Drug resistance | Gene deletion | Fibronectin | Metastases | Microenvironments | Differentiation
Journal Article
Pigment Cell and Melanoma Research, ISSN 1755-1471, 12/2008, Volume 21, Issue 6, pp. 665 - 676
Journal Article
by Shaw, Natalie D and Brand, Harrison and Kupchinsky, Zachary A and Bengani, Hemant and Plummer, Lacey and Jones, Takako I and Erdin, Serkan and Williamson, Kathleen A and Rainger, Joe and Stortchevoi, Alexei and Samocha, Kaitlin and Currall, Benjamin B and Dunican, Donncha S and Collins, Ryan L and Willer, Jason R and Lek, Angela and Lek, Monkol and Nassan, Malik and Pereira, Shahrin and Kammin, Tammy and Lucente, Diane and Silva, Alexandra and Seabra, Catarina M and Chiang, Colby and An, Yu and Ansari, Morad and Rainger, Jacqueline K and Joss, Shelagh and Smith, Jill Clayton and Lippincott, Margaret F and Singh, Sylvia S and Patel, Nirav and Jing, Jenny W and Law, Jennifer R and Ferraro, Nalton and Verloes, Alain and Rauch, Anita and Steindl, Katharina and Zweier, Markus and Scheer, Ianina and Sato, Daisuke and Okamoto, Nobuhiko and Jacobsen, Christina and Tryggestad, Jeanie and Chernausek, Steven and Schimmenti, Lisa A and Brasseur, Benjamin and Cesaretti, Claudia and García-Ortiz, Jose E and Buitrago, Tatiana Pineda and Silva, Orlando Perez and Hoffman, Jodi D and Mühlbauer, Wolfgang and Ruprecht, Klaus W and Loeys, Bart L and Shino, Masato and Kaindl, Angela M and Cho, Chie-Hee and Morton, Cynthia C and Meehan, Richard R and van Heyningen, Veronica and Liao, Eric C and Balasubramanian, Ravikumar and Hall, Janet E and Seminara, Stephanie B and Macarthur, Daniel and Moore, Steven A and Yoshiura, Koh-Ichiro and Gusella, James F and Marsh, Joseph A and Graham, Jr, John M and Lin, Angela E and Katsanis, Nicholas and Jones, Peter L and Crowley, Jr, William F and Davis, Erica E and FitzPatrick, David R and Talkowski, Michael E
Nature genetics, ISSN 1061-4036, 05/2017, Volume 49, Issue 6, pp. 969 - 969
Genet. 49, 238-248 (2017); published online 9 January 2017; corrected after print 20 March 2017 In the version of this article initially published, the legend... 
Dystrophy | Mutation | Muscular dystrophy | Microphthalmia
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2013, Volume 14, Issue 10, pp. 20443 - 20458
Gallic acid is one of the major flavonoids found in plants. It acts as an antioxidant, and seems to have anti-inflammatory, anti-viral, and anti-cancer... 
Dct | Gallic acid | Wnt/β-catenin | MEK/ERK | TRP1 | Melanogenesis | Tyrosinase | Microphthalmia-associated transcription factor (MITF) | PI3K/Akt | CARCINOMA CELLS | catenin | melanogenesis | MITF | Akt | MICROPHTHALMIA GENE-PRODUCT | tyrosinase | gallic acid | HUMAN MELANOCYTES | CHEMISTRY, MULTIDISCIPLINARY | MEK | PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY | PI3K | microphthalmia-associated transcription factor (MITF) | MELANOMA-CELLS | Wnt | NEURAL CREST | TRANSCRIPTION FACTOR | CAMP | ERK | Gallic Acid - pharmacology | Melanoma, Experimental - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Wnt Proteins - metabolism | Melanins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | MAP Kinase Signaling System - genetics | Wnt Proteins - genetics | Monophenol Monooxygenase - genetics | Intramolecular Oxidoreductases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Microphthalmia-Associated Transcription Factor - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Signal Transduction - genetics | Melanins - genetics | Down-Regulation - drug effects | beta Catenin - metabolism | Down-Regulation - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | Melanoma, Experimental - genetics | Intramolecular Oxidoreductases - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Mice | Microphthalmia-Associated Transcription Factor - genetics | Index Medicus
Journal Article
Steroids, ISSN 0039-128X, 2011, Volume 76, Issue 12, pp. 1297 - 1304
► Diethylstilbestrol increase B16 melanoma cell proliferation, melanin synthesis and tyrosinase’s activity. ► Diethylstilbestrol increased the expressions of... 
Microphthalmia related transcription factor (MITF) | Melanogenesis | Protein kinase A (PKA) | Diethylstilbestrol (DES) | Tyrosinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | P38 MAPK | HUMAN MELANOCYTES | SIGNAL-TRANSDUCTION | MELASMA | ENDOCRINOLOGY & METABOLISM | ESTROGEN | MICROPHTHALMIA | SKIN | PIGMENTATION | HORMONES | Humans | Melanocytes - metabolism | Melanoma, Experimental - metabolism | Melanins - biosynthesis | Monophenol Monooxygenase - metabolism | Diethylstilbestrol - pharmacology | Isoquinolines - pharmacology | Melanocytes - drug effects | Estrogen Receptor alpha - metabolism | Estrogens - metabolism | Cyclic AMP-Dependent Protein Kinases - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Survival - drug effects | Microphthalmia-Associated Transcription Factor - metabolism | Monophenol Monooxygenase - drug effects | Microphthalmia-Associated Transcription Factor - drug effects | Cyclic AMP | Estrogen Receptor alpha - antagonists & inhibitors | Sulfonamides - pharmacology | Animals | Estrogen Receptor alpha - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Microphthalmia-Associated Transcription Factor - genetics | Proteins | Messenger RNA | Medical genetics | Melanoma | Phenols | Diethylstilbestrol | Universities and colleges | Protein kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8668 - E8677
The close integration of the MAPK, PI3K, and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial... 
MITF | MAPK | GSK3 | Melanoma | Nuclear export | STEM-CELLS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | melanoma | TRANSCRIPTION FACTOR MITF | nuclear export | MUTATION | RESISTANCE | MICROPHTHALMIA | MAPK PATHWAY | EXPRESSION | MASTER REGULATOR | Melanoma - metabolism | Phosphorylation | Microphthalmia-Associated Transcription Factor - metabolism | Humans | Cells, Cultured | Melanoma - pathology | Glycogen Synthase Kinase 3 - metabolism | MAP Kinase Signaling System | Animals | Cell Nucleus - metabolism | Melanoma - genetics | Cell Line, Tumor | Protein Binding | Active Transport, Cell Nucleus | HeLa Cells | Mutation | Microphthalmia-Associated Transcription Factor - genetics | Proto-Oncogene Proteins B-raf - metabolism | Physiological aspects | Transcription factors | Cellular signal transduction | Research | TOR protein | Deregulation | Wnt protein | Melanocytes | Retina | Hydrophobicity | Kinases | Retinal pigment epithelium | Convergence | Signal transduction | Biomedical materials | Control | Pathways | Cell cycle | Biocompatibility | Combinatorics | Microphthalmia-associated transcription factor | Cell survival | MAP kinase | Metabolism | Epithelium | Survival | Nuclear transport | Exports | 1-Phosphatidylinositol 3-kinase | Signaling | Isoforms | Stem cells | Osteoclasts | Mast cells | Combinatorial analysis | Cell migration | Cancer | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 104 - 107
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2017, Volume 140, Issue 1, pp. 204 - 214.e8
We have recently observed that oxidative phosphorylation–mediated ATP production is essential for mast cell function. Pyruvate dehydrogenase (PDH) is the main... 
pyruvate dehydrogenase | Allergy | microphthalmia transcription factor | mitochondria | cytokines | asthma | degranulation | mast cells | B-LYMPHOCYTES | ACTIVATION | EXOCYTOSIS | PHOSPHATASE | MITF | IMMUNOLOGY | CALCIUM INFLUX | METABOLISM | GENE | EXPRESSION | Ovalbumin - immunology | Cell Count | Humans | Male | Mitochondria - immunology | Exocytosis | Allergens - immunology | Adenosine Triphosphate - metabolism | Microphthalmia-Associated Transcription Factor - immunology | Asthma - immunology | HEK293 Cells | Mast Cells - metabolism | Female | Bronchoalveolar Lavage Fluid - cytology | Mast Cells - immunology | Cell Degranulation | Cells, Cultured | Rats | Mast Cells - physiology | Mitochondria - metabolism | Mice, Inbred C3H | Animals | Ketone Oxidoreductases - immunology | Cell Line, Tumor | Mice, Inbred BALB C | Microphthalmia-Associated Transcription Factor - genetics | Proteins | Medical research | Pharmacy | Medicine, Experimental | Jewish schools | Drugstores | Research institutes | Molecular biology | Heat shock proteins | Tricarboxylic acid cycle | Phosphorylation | Transcription factors | Dehydrogenases | Leukemia | Serine | Pyruvic acid | Activation | Allergic diseases | Kinases | Dehydrogenase | Krebs cycle | Electron transport chain | Signal transduction | Mitochondria | Lymphocytes | Inhibition | Localization | Microphthalmia-associated transcription factor | Antigens | Cytokines | T cell receptors | Metabolism | Gene expression | Diseases | Oxidative phosphorylation | Human performance | Degranulation | Mice | Mast cells | Mutation | Electron transport | Position (location) | ATP | Index Medicus | Abridged Index Medicus
Journal Article