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BBA - Biomembranes, ISSN 0005-2736, 06/2016, Volume 1858, Issue 6, pp. 1110 - 1117
MICU1 and MICU2 are the main regulators of the mitochondrial Ca2+-uniporter (MCU), but their precise functional role is still under debate. We show here that... 
HeLa cells | Aequorin | MICU2 | Calcium | MICU1 | MCU
Journal Article
Circulation, ISSN 0009-7322, 11/2019, Volume 140, Issue 21, pp. 1720 - 1733
BACKGROUND:The mitochondrial calcium uniporter (mtCU) is an ≈700-kD multisubunit channel residing in the inner mitochondrial membrane required for... 
RUTHENIUM RED | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MICU1 protein | calcium channels | mitochondria | MEMBRANE | calcium signaling | reperfusion injury | GATEKEEPER | MCUB protein | oxidative phosphorylation | RESPONSES | THRESHOLD | INHIBITION | CA2 | PORE | PERIPHERAL VASCULAR DISEASE | MICU1 | human
Journal Article
Cell Reports, ISSN 2211-1247, 01/2016, Volume 14, Issue 3, pp. 403 - 410
The mitochondrial uniporter (MCU) is an ion channel that mediates Ca2+ uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca2+... 
RECEPTOR | LIVER-MITOCHONDRIA | MICU1 | CALCIUM UNIPORTER | CELL BIOLOGY
Journal Article
Molecular cell, ISSN 1097-2765, 6/2017, Volume 66, Issue 6, pp. 780 - 788
Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific... 
Endoplasmic Reticulum | STIM1 | MICU1 | mitochondria | Miro1 | IP3 receptor
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 2015, Volume 1350, Issue 1, pp. 107 - 116
Journal Article
Biochimica et biophysica acta. Molecular cell research, ISSN 0167-4889, 2017, Volume 1864, Issue 6, pp. 1009 - 1017
Journal Article
Molecular cell, ISSN 1097-2765, 2014, Volume 55, Issue 2, pp. 332 - 341
Obtaining complete protein inventories for subcellular regions is a challenge that often limits our understanding of cellular function, especially for regions... 
AUTOPHAGOSOMES | COMPLEX | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM UNIPORTER | BIOLOGY | CA2+ UPTAKE | MICU1 | PROTEINS | ENCODED FLUORESCENT REPORTERS | LIVING CELLS | CELL BIOLOGY | Cell Fractionation | Mitochondrial Proteins - metabolism | Humans | HEK293 Cells | Isotope Labeling | Proteome - metabolism | Blotting, Western | Mitochondrial Membranes - metabolism | Proteins | Analysis
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2015, Volume 22, Issue 4, pp. 721 - 733
The essential oxidoreductase Mia40/CHCHD4 mediates disulfide bond formation and protein folding in the mitochondrial intermembrane space. Here, we investigated... 
CHCHD4 | disulfide | Ca2 | mitochondria | MICU | MCUx | Mia40 | redox | YEAST MITOCHONDRIA | CELLS | ELECTRON-TRANSFER | INNER MEMBRANE | GLUTATHIONE | CALCIUM UNIPORTER | ENDOCRINOLOGY & METABOLISM | PROTEIN IMPORT | MICU1 | INTERMEMBRANE SPACE | MIA40 | CELL BIOLOGY
Journal Article
Thyroid (New York, N.Y.), ISSN 1050-7256, 12/2019, Volume 29, Issue 12, pp. 1755 - 1764
Background: Thyroid hormone status in hypothyroidism (HT) downregulates key elements in Ca 2+ handling within the heart, reducing contractility, impairing the... 
calcium | hypothyroidism | mitochondria | Thyroid Dysfunction | uniporter | MICU1 | Hypothyroidism, Thyrotoxicosis, and Thyroid Function Tests
Journal Article
Journal of Integrative Neuroscience, ISSN 0219-6352, 06/2016, Volume 15, Issue 2, pp. 163 - 173
Calcium signaling is important for synaptic plasticity, generation of brain rhythms, regulating neuronal excitability, data processing and cognition.... 
mutation | EF-hand calcium binding domain | single nucleotide polymorphism | mitochondrial Ca | uniporter | Bipolar disorder | uptake 1 (MICU1) | UNIPORTER | RDOC | mitochondrial Ca2+ uptake 1 (MICU1) | SCHIZOPHRENIA | MICU1 | NEUROSCIENCES | mitochondrial Ca2+ uniporter | MCU
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 6, pp. 780 - 788
Ca2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific... 
STIM1 | MICU1 | mitochondria | Miro1 | endoplasmic reticulum | IP3 receptor | receptor | STRUCTURAL BASIS | VENTRICULAR-TACHYCARDIA | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING DOMAIN | CARDIAC RYANODINE RECEPTOR | CA2+-ACTIVATED K+ CHANNEL | ACTIVATES CRAC CHANNELS | MITOCHONDRIAL CA2 | PLASMA-MEMBRANE | PERMEABILITY TRANSITION | CELL BIOLOGY
Journal Article
NATURE METHODS, ISSN 1548-7091, 01/2015, Volume 12, Issue 1, pp. 51 - 54
APEX is an engineered peroxidase that functions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics. Because limited... 
INACTIVATION | PROTEIN | MEMBRANE | BIOCHEMICAL RESEARCH METHODS | CA2+ UPTAKE | HYDROGEN-PEROXIDE | HORSERADISH-PEROXIDASE | CELL-SURVIVAL | MICU1 | MITOCHONDRIAL CALCIUM UNIPORTER | ASCORBATE PEROXIDASE
Journal Article
Journal Article