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Journal Article
Circulation, ISSN 0009-7322, 04/2016, Volume 133, Issue 14, pp. 1360 - 1370
BACKGROUND—The hypertensive syndrome of Apparent Mineralocorticoid Excess is caused by loss-of-function mutations in the gene encoding 11β-hydroxysteroid... 
pressoreceptors | salt | solitary nucleus | mineralocorticoids | aldosterone | APPARENT MINERALOCORTICOID EXCESS | CARDIAC & CARDIOVASCULAR SYSTEMS | SODIUM APPETITE | BAROREFLEX SENSITIVITY | DISTAL TUBULE | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 | HEART-FAILURE | INTRACEREBROVENTRICULAR INFUSION | BLOOD-PRESSURE | PERIPHERAL VASCULAR DISEASE | MICE | Mineralocorticoid Excess Syndrome, Apparent - drug therapy | Mineralocorticoid Excess Syndrome, Apparent - genetics | Nerve Tissue Proteins - deficiency | Solitary Nucleus - enzymology | Receptors, Mineralocorticoid - physiology | RNA, Messenger - biosynthesis | Nephrons - physiopathology | Dexamethasone - pharmacology | Spironolactone - pharmacology | Reflex, Abnormal | Nestin - genetics | Neurons - physiology | Mineralocorticoid Excess Syndrome, Apparent - physiopathology | Craving - physiology | Corticosterone - blood | Hypertension - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Solitary Nucleus - physiopathology | Nerve Tissue Proteins - physiology | Mice, Inbred C57BL | Genes, Synthetic | Nerve Tissue Proteins - genetics | Hypertension - physiopathology | Drinking Behavior | Mice, Knockout | Mineralocorticoid Receptor Antagonists - therapeutic use | Baroreflex - drug effects | Animals | Sodium Chloride, Dietary - toxicity | Potassium - urine | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - physiology | Mice | Hypertension | Measurement | Care and treatment | Phenylephrine | Blood pressure | Dosage and administration | Cardiovascular diseases | 10111 | 10014 | 10058 | Original
Journal Article
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2015, Volume 26, Issue 4, pp. 201 - 211
Highlights • Mineralocorticoid receptor (MR) antagonists have proven benefits in hypertension and heart failure. • Atrial fibrillation (AF), pulmonary... 
Endocrinology & Metabolism | novel indications | mineralocorticoid receptor | spironolactone | eplerenone | Eplerenone | Spironolactone | Mineralocorticoid receptor | Novel indications | CHRONIC HEART-FAILURE | ALDOSTERONE ANTAGONISTS | MYOCARDIAL-INFARCTION | PLASMA-ALDOSTERONE | LEFT-VENTRICULAR HYPERTROPHY | ANTI-ALDOSTERONE | ATRIAL-FIBRILLATION | RENIN-ANGIOTENSIN SYSTEM | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | STAGE RENAL-DISEASE | Severity of Illness Index | Arrhythmias, Cardiac - prevention & control | Receptors, Mineralocorticoid - agonists | Cardiovascular Diseases - physiopathology | Off-Label Use | Cardiovascular Diseases - metabolism | Receptors, Mineralocorticoid - metabolism | Cardiovascular Diseases - drug therapy | Humans | Death, Sudden, Cardiac - prevention & control | Arrhythmias, Cardiac - etiology | Death, Sudden, Cardiac - etiology | Disease Progression | Hypertension, Pulmonary - prevention & control | Mineralocorticoid Receptor Antagonists - therapeutic use | Heart Failure - prevention & control | Cardiovascular Agents - therapeutic use | Animals | Models, Biological | Heart Failure - etiology | Hypertension, Pulmonary - etiology | Receptors, Mineralocorticoid - chemistry | Heart failure | Hypertension | Heart | Hospitals | Atrial fibrillation | Steroids | Cardiovascular Diseases | Receptors, Mineralocorticoid | Hypertension, Pulmonary | Arrhythmias, Cardiac | Cardiovascular Agents | Death, Sudden, Cardiac | Life Sciences | Human health and pathology | Heart Failure | Mineralocorticoid Receptor Antagonists | Cardiology and cardiovascular system
Journal Article
Circulation, ISSN 0009-7322, 04/2009, Volume 119, Issue 16, pp. 2179 - 2187
Background-The mineralocorticoid pathway is involved in cardiac arrhythmias associated with heart failure through mechanisms that are incompletely understood.... 
Ion channels | Hormones | Arrhythmia | Calcium | aldosterone | Ryanodine receptor | FKBP12.6 OVEREXPRESSION | ARRHYTHMIAS | CARDIAC & CARDIOVASCULAR SYSTEMS | calcium | MYOCARDIAL-INFARCTION | hormones | HEART-FAILURE | ion channels | SARCOPLASMIC-RETICULUM CA2 | CONTRACTION | arrhythmia | CALCIUM-RELEASE | PERIPHERAL VASCULAR DISEASE | ryanodine receptor | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | SPARKS | Protein Kinases - metabolism | Rats, Wistar | Receptors, Mineralocorticoid - metabolism | Calcium Signaling - physiology | Humans | Heart Failure - physiopathology | Male | Ryanodine Receptor Calcium Release Channel - metabolism | Tacrolimus Binding Proteins - metabolism | Arrhythmias, Cardiac - physiopathology | Aldosterone - metabolism | Sarcoplasmic Reticulum - metabolism | Arrhythmias, Cardiac - metabolism | Mineralocorticoids - metabolism | Myocytes, Cardiac - cytology | Cells, Cultured | Rats | Aldosterone - pharmacology | Mice, Transgenic | Heart Failure - metabolism | Down-Regulation - physiology | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - metabolism | Mice | TOR Serine-Threonine Kinases | Heart failure | Physiological aspects | Mineralocorticoids | Cardiovascular receptors | Research | Binding proteins | Risk factors | Myocytes, Cardiac | Ryanodine Receptor Calcium Release Channel | Down-Regulation | Tacrolimus Binding Proteins | Receptors, Mineralocorticoid | Arrhythmias, Cardiac | Sarcoplasmic Reticulum | Aldosterone | Life Sciences | Human health and pathology | Protein Kinases | Heart Failure | Calcium Signaling | Cardiology and cardiovascular system
Journal Article
Journal Article
Journal of Psychopharmacology, ISSN 0269-8811, 12/2013, Volume 27, Issue 12, pp. 1169 - 1179
Background: Treatment-resistant depression patients show both reduced glucocorticoid receptor function and a hyperactive hypothalamic-pituitary-adrenal axis.... 
hypothalamic-pituitary-adrenal axis | prednisolone | Cortisol | mineralocorticoid receptor | treatment resistant depression | mineralocorticoid receptor antagonist | PSYCHIATRY | PREDNISOLONE SUPPRESSION TEST | HUMANS | CHILDHOOD EXPERIENCE | MAJOR DEPRESSION | NEUROSCIENCES | CLINICAL NEUROLOGY | CANRENOATE | GLUCOCORTICOID-RECEPTOR | PHARMACOLOGY & PHARMACY | HPA AXIS | PITUITARY-ADRENAL AXIS | BRAIN | Single-Blind Method | Mineralocorticoid Receptor Antagonists - administration & dosage | Prednisolone - administration & dosage | Spironolactone - administration & dosage | Pituitary-Adrenal System - metabolism | Receptors, Mineralocorticoid - metabolism | Humans | Middle Aged | Hydrocortisone - metabolism | Male | Receptors, Glucocorticoid - metabolism | Saliva - chemistry | Prednisolone - pharmacology | Case-Control Studies | Hypothalamo-Hypophyseal System - metabolism | Spironolactone - pharmacokinetics | Depressive Disorder, Treatment-Resistant - physiopathology | Receptors, Mineralocorticoid - drug effects | Spironolactone - pharmacology | Canrenone - metabolism | Mineralocorticoid Receptor Antagonists - pharmacology | Female | Receptors, Glucocorticoid - drug effects | Mineralocorticoid Receptor Antagonists - pharmacokinetics | Physiological aspects | Mineralocorticoids | Hypothalamic-pituitary-adrenal axis | Care and treatment | Research | Depression, Mental
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2014, Volume 34, Issue 2, pp. 355 - 364
OBJECTIVE—Vascular remodeling occurs after endothelial injury, resulting in smooth muscle cell (SMC) proliferation and vascular fibrosis. We previously... 
placental growth factor | receptors mineralocorticoid | vascular endothelial growth factor receptor-1 | aldosterone | myocytes smooth muscle | MORTALITY | OXIDATIVE STRESS | EVENTS | receptors | smooth muscle | myocytes | mineralocorticoid | BLOOD-PRESSURE | SPIRONOLACTONE | PERIPHERAL VASCULAR DISEASE | EPLERENONE | HYPERTENSION | HEMATOLOGY | EXPRESSION | BLOCKER | GENE-TRANSCRIPTION | Carotid Arteries - drug effects | Carotid Arteries - metabolism | Receptors, Mineralocorticoid - agonists | Receptors, Mineralocorticoid - genetics | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Muscle, Smooth, Vascular - metabolism | Pregnancy Proteins - genetics | Myocytes, Smooth Muscle - pathology | Male | Pregnancy Proteins - metabolism | RNA, Messenger - metabolism | Receptors, Mineralocorticoid - deficiency | Time Factors | Carotid Artery Injuries - genetics | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Carotid Artery Injuries - metabolism | Carotid Artery Injuries - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Endothelial Cells - metabolism | Mice, Inbred C57BL | Aldosterone - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Animals | Fibrosis | Placenta Growth Factor | Carotid Arteries - pathology | Cell Proliferation - drug effects | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | smooth muscle cells | mineralocorticoid receptor | vascular remodeling | VEGF
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 4105 - 4114
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2015, Volume 761, pp. 226 - 234
The present study was designed to characterize the pharmacological profile of CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist. In the... 
CS-3150 | Aldosterone | Urinary Na+/K+ ratio | Mineralocorticoid receptor antagonist | Urinary Na | ratio | TARGET | OXIDATIVE STRESS | DIABETIC-NEPHROPATHY | MESSENGER-RNA | PHARMACOKINETICS | SPIRONOLACTONE | INFLAMMATION | ALDOSTERONE BLOCKER | PHARMACOLOGY & PHARMACY | HYPERTENSION | EPLERENONE | Receptors, Mineralocorticoid - genetics | Urological Agents - pharmacology | Antihypertensive Agents - pharmacology | Pyrroles - pharmacokinetics | Receptors, Mineralocorticoid - metabolism | Humans | Transcriptional Activation - drug effects | Rats, Inbred WKY | Desoxycorticosterone Acetate | Male | Water-Electrolyte Balance - drug effects | Spironolactone - metabolism | Sulfones - pharmacology | Dose-Response Relationship, Drug | Receptors, Mineralocorticoid - drug effects | Aldosterone - metabolism | Spironolactone - pharmacology | Transfection | Sodium - urine | Pyrroles - administration & dosage | Hypertension - chemically induced | HEK293 Cells | Mineralocorticoid Receptor Antagonists - pharmacology | Hypertension - prevention & control | Female | Blood Pressure - drug effects | Radioligand Assay | Spironolactone - analogs & derivatives | Disease Models, Animal | Binding, Competitive | Mineralocorticoid Receptor Antagonists - administration & dosage | Rabbits | Administration, Oral | Aldosterone - pharmacology | Sulfones - pharmacokinetics | Rats, Sprague-Dawley | Hypertension - physiopathology | Adrenalectomy | Pyrroles - pharmacology | Animals | Eplerenone | Potassium - urine | Protein Binding | Mineralocorticoid Receptor Antagonists - pharmacokinetics | Sulfones - administration & dosage | Hypertension | Hormones, Sex | Corticosteroids | Drug discovery | Spironolactone
Journal Article
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 8, pp. 3745 - 3757
The mineralocorticoid receptor (MR) controls adipocyte function, but its role in the conversion of white adipose tissue (WAT) into thermogenic fat has not been... 
UCP1 | Obesity | Aldosterone | Metabolic syndrome | Uncoupling protein 1 | Adipogenesis | aldosterone | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | ADULT HUMANS | ORGAN | CELL BIOLOGY | metabolic syndrome | uncoupling protein 1 | GLUCOSE-HOMEOSTASIS | adipogenesis | IN-VIVO | BIOLOGY | GENE-EXPRESSION | DIFFERENTIATION | obesity | Inguinal Canal | Obesity - drug therapy | Adipogenesis - drug effects | Diet, High-Fat - adverse effects | Ion Channels - genetics | Adipocytes - cytology | Androstenes - pharmacology | Gene Expression Profiling | Mitochondrial Proteins - genetics | Adipocytes - drug effects | Autophagy - drug effects | Adipogenesis - physiology | Receptors, Mineralocorticoid - physiology | Receptors, Mineralocorticoid - drug effects | Glucose Intolerance - prevention & control | Spironolactone - pharmacology | Body Composition - drug effects | Glucose Intolerance - etiology | Cell Transdifferentiation - drug effects | Mineralocorticoid Receptor Antagonists - pharmacology | Macrolides - pharmacology | Female | Weight Gain - drug effects | Intra-Abdominal Fat - drug effects | Spironolactone - therapeutic use | Ion Channels - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Androstenes - therapeutic use | Aldosterone - pharmacology | Obesity - physiopathology | Mitochondrial Proteins - biosynthesis | Mineralocorticoid Receptor Antagonists - therapeutic use | Up-Regulation - drug effects | Animals | Obesity - prevention & control | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | Adipose Tissue, White - drug effects
Journal Article