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Cardiovascular research, ISSN 0008-6363, 2014, Volume 104, Issue 1, pp. 61 - 71
The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the... 
miRNA-15 family | TGFβ-pathway | Fibrosis | Hypertrophy | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | LEFT-VENTRICULAR FIBROSIS | IMPROVES SURVIVAL | TGF beta-pathway | MIR-15 FAMILY | FAILURE | MYOCARDIAL FIBROSIS | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | TRANSGENIC MICE | Up-Regulation | Receptors, Transforming Growth Factor beta - genetics | Humans | Cercopithecus aethiops | Cardiomegaly - pathology | MicroRNAs - metabolism | Smad3 Protein - metabolism | Case-Control Studies | Cardiomyopathies - genetics | Smad3 Protein - genetics | Cardiomyopathies - physiopathology | Ventricular Remodeling | Transfection | p38 Mitogen-Activated Protein Kinases - metabolism | 3' Untranslated Regions | Smad7 Protein - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Smad7 Protein - metabolism | Rats, Transgenic | Signal Transduction | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Cardiomegaly - physiopathology | p38 Mitogen-Activated Protein Kinases - genetics | Cardiomyopathies - pathology | Hep G2 Cells | Animals | Receptors, Transforming Growth Factor beta - metabolism | Cardiomyopathies - metabolism | Myocytes, Cardiac - metabolism | MicroRNAs - genetics | Cardiomegaly - genetics | COS Cells | Transforming Growth Factor beta - metabolism | Cardiomegaly - metabolism | Index Medicus
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 8/2017, Volume 54, Issue 6, pp. 4329 - 4342
Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active... 
Neurology | Neurosciences | CDK5R1/p35 | Biomedicine | Alzheimer’s disease | CDK5 | Neurobiology | miR-15/107 | Post-transcriptional regulation | Cell Biology
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2019, Volume 508, Issue 3, pp. 832 - 837
The hedgehog signaling pathway is a crucial regulator of the postnatal intestinal development. Regulation of hedgehog expression itself is poorly understood.... 
miR-15 family | Hedgehog signaling | microRNA | Postnatal development | Intestinal development | Pig | MANAGEMENT | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | Index Medicus
Journal Article
BMC medical genetics, ISSN 1471-2350, 05/2019, Volume 20, Issue 1, pp. 96 - 96
The highly conservative miR-15/107 family (also named as miR-15/107 gene group) including ten miRNA members is currently recognized strongly implicated in... 
Usage | MicroRNA | Nucleotide sequencing | Research | Computational biology | DNA sequencing | Cell proliferation | Transcription | Leukemia | Genes | MiRNA | Genomes | Kinases | Investigations | Data bases | Cell growth | Archives & records | MicroRNAs | Regulation | Alzheimers disease | Bioinformatics | Cancer | miR-15/107 family | Interaction network | Target gene
Journal Article
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 08/2017, Volume 54, Issue 6, pp. 4329 - 4342
Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active... 
NEUROFIBRILLARY TANGLES | MESSENGER-RNA EXPRESSION | UNTRANSLATED REGIONS | miR-15/107 | NEURODEGENERATION | AMYLOID PRECURSOR PROTEIN | CDK5 ACTIVITY | NEUROSCIENCES | CDK5R1/p35 | P25 | ACTIVATOR | CDK5 | CHRONIC BRAIN HYPOPERFUSION | Post-transcriptional regulation | Alzheimer's disease | CYCLIN-DEPENDENT KINASE-5 | Amyloid Precursor Protein Secretases - genetics | Humans | RNA, Messenger - genetics | Gene Expression Regulation | MicroRNAs - metabolism | Hippocampus - pathology | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | Temporal Lobe - metabolism | Nerve Tissue Proteins - genetics | Case-Control Studies | Alzheimer Disease - pathology | Cyclin-Dependent Kinase 5 | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Aspartic Acid Endopeptidases - metabolism | HEK293 Cells | Cell Line, Tumor | MicroRNAs - genetics | Alzheimer Disease - genetics | Temporal Lobe - pathology | Brain | Deregulation | MicroRNA | Genes | Cerebellum | Post-transcription | Phosphorylation | Cerebral cortex | Transcription | Pathogenesis | Disorders | Tissues | Cyclin-dependent kinase 5 | Cyclin-dependent kinase | Cortex (temporal) | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Cyclin-dependent kinases | Cortex | MiRNA | Light emitting diodes | Ribonucleic acid--RNA | Ribonucleic acids | 3' Untranslated regions | Alzheimers disease | Hippocampus | Index Medicus
Journal Article
基因组蛋白质组与生物信息学报:英文版, ISSN 1672-0229, 2014, Volume 12, Issue 1, pp. 19 - 30
The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs),sharing a 5' AGCAGC sequence.These miRNAs have overlapping targets.In order to... 
miRNA | 培养物 | 皮质神经元 | 小分子RNA | 脑细胞 | 人体组织 | miR-16 | Normalization | miR-424 | miR-503 | miR-15 | Target prediction | MiR-15 | MiR-424 | MiR-503 | MiR-16 | Brain - metabolism | Microglia - metabolism | Animals | Humans | Cells, Cultured | Rats | MicroRNAs - metabolism | Gene Expression Profiling | MicroRNAs - genetics | Neurons - metabolism | Cluster Analysis | Original Research
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 34, pp. 13839 - 13844
The adult mammalian heart has limited potential for regeneration. Thus, after injury, cardiomyocytes are permanently lost, and contractility is diminished. In... 
Heart | Regeneration | Transcription factors | Ligation | Alleles | Fibrosis | Myocardium | Photoreceptors | Left coronary artery | Cardiac output | Cardiac fibrosis | Cardiomyopathy | Cell cycle | TRANSCRIPTION FACTORS | F-ACTIN | cell cycle | ORGAN SIZE CONTROL | MULTIDISCIPLINARY SCIENCES | CARDIOMYOCYTE PROLIFERATION | ZEBRAFISH HEART REGENERATION | MIR-15 FAMILY | TEAD/TEF FAMILY | cardiac fibrosis | SIGNALING PATHWAY | IN-VIVO | cardiomyopathy | HOLT-ORAM-SYNDROME | Echocardiography | Heart - physiology | Myocardial Contraction - physiology | Mice, Transgenic | DNA Primers - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Phosphoproteins - metabolism | Regeneration - physiology | Blotting, Western | Mutation, Missense - genetics | Tetrazolium Salts | Transcription Factors - metabolism | Myocardial Contraction - genetics | Animals | Histological Techniques | Myocytes, Cardiac - physiology | Adaptor Proteins, Signal Transducing - genetics | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proteins | Molecular genetics | Heart cells | Cellular control mechanisms | Physiological aspects | Genetic aspects | Regeneration (Biology) | Research | Signal transduction | Tissue engineering | Rodents | Cardiomyocytes | Insulin-like growth factors | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
European Journal of Heart Failure, ISSN 1388-9842, 08/2016, Volume 18, Issue 8, pp. 1000 - 1008
Journal Article
JOURNAL OF BONE AND MINERAL RESEARCH, ISSN 0884-0431, 05/2015, Volume 30, Issue 5, pp. 796 - 808
MicroRNAs play important roles during cell reprogramming and differentiation. In this study, we identified the miR-497 approximate to 195 cluster, a member of... 
OSTEOBLAST DIFFERENTIATION | BONE MORPHOGENETIC PROTEIN-2 | DOWN-REGULATION | FUNCTIONAL-CHARACTERIZATION | PROLIFERATION | BETA | BMP SIGNALING | HEPATOCELLULAR-CARCINOMA | miR-15 FAMILY | PATHWAY | miR-497 | EMBRYONIC STEM-CELLS | GROWTH | ENDOCRINOLOGY & METABOLISM | miR-195 | TRANSCRIPTION FACTOR
Journal Article