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PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0153731
Journal Article
Neural Regeneration Research, ISSN 1673-5374, 10/2019, Volume 14, Issue 10, pp. 1672 - 1677
Journal Article
Frontiers in genetics, ISSN 1664-8021, 2012, Volume 3, p. 120
MicroRNA-34 (miR-34) is a master regulator of tumor suppression. It is downregulated in numerous cancers and inhibits malignant growth by repressing genes... 
Mir-34a | Mir-34 | MiRNA replacement | MiRNA therapeutics | MiRNA | miRNA replacement | miRNA therapeutics | miRNA | miR-34 | miR-34a
Journal Article
Briefings in Bioinformatics, ISSN 1467-5463, 05/2013, Volume 14, Issue 3, pp. 263 - 278
Journal Article
Frontiers in Molecular Neuroscience, ISSN 1662-5099, 10/2013, Volume 6, p. 33
Journal Article
eLife, ISSN 2050-084X, 08/2015, Volume 4, Issue 2015
MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical... 
WIDESPREAD | PROTEIN | WIDE IDENTIFICATION | REPRESSION | MIRNA | IN-VIVO | GENES | BIOLOGY | ALTERNATIVE POLYADENYLATION | BINDING-SITES | GENOME BROWSER DATABASE | Computational Biology - methods | Animals | RNA, Messenger - genetics | Gene Expression Regulation | MicroRNAs - metabolism | MicroRNAs - genetics | Mammals | RNA, Messenger - metabolism | Binding Sites | Molecular Biology - methods
Journal Article
Development, ISSN 0950-1991, 09/2006, Volume 133, Issue 18, pp. 3539 - 3547
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 47 - 60
In the 12 years since the process of RNA interference (RNAi) was first discovered, great progress has been made in understanding its mechanism and exploiting... 
siRNA or miRNA seed sequence | RISC | microRNA (miRNA) | GENOME-WIDE RNAI | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | Short interfering RNA (siRNA) | FUNCTIONAL DISSECTION | MAMMALIAN-CELLS | DEPENDENT STIMULATION | SMALL INTERFERING RNAS | MESSENGER-RNAS | RNA Interference | RNAI off-target effect | GENE-EXPRESSION | C-ELEGANS | siRNA multiplicity validation | HIV-1 REPLICATION | RNA, Small Interfering - genetics | Gene Expression | Down-Regulation | Genomics | RNA, Messenger - genetics | Untranslated Regions | Validation Studies as Topic | Transcription, Genetic | MicroRNAs - genetics | RNA, Double-Stranded - chemistry | Genetic Techniques - standards | RNA, Small Interfering - metabolism | Short interfering RNA (siRNA): An endogenous or artificial (synthetic) small double strand RNA with perfect pairing of the two strands. One strand (called the guide strand) targets RISC to perfectly complementary mRNAs, resulting in endonucleolytic cleavage of the mRNA by the RISC component Ago2 | siRNA or miRNA seed sequence: The 5′ region of the guide strand of an siRNA or miRNA sequence, extending from nucleotides 2–7 (hexamer) or 2–8 (heptamer) | or mRNA decay | siRNA multiplicity validation: Validation of a gene-phenotype association by showing that the phenotype can be produced by multiple independent siRNAs that target different regions of the same mRNA | MicroRNA (miRNA): A mature endogenous small double strand RNA, often with imperfect pairing of the two strands, originating from processing of a precursor RNA molecule by cellular RNases. miRNAs target RISC complexes to sites that have imperfect sequence complementarity, and that are typically located in the 3′ untranslated region of the mRNA | RISC: The RNA-Induced Silencing Complexes are multi-protein complexes containing an Argonaute protein, a small single strand RNA and additional regulatory proteins | RNA interference: A cellular process that downregulates gene expression at a post-transcriptional step. One strand of a small double strand RNA (siRNA or miRNA) integrates in a protein complex called RISC and targets an mRNA with sequence complementarity for cleavage, translation inhibition and | RNAi off-target effect: Any effect of an RNAi-based treatment that is a consequence of reducing the expression of an unintended target
Journal Article