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by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St. Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Mathew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Canc Susceptib Collaborat and Wellcome Trust Case Control Cons and Biol RA Genet & Genom Study and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 02/2019, Volume 216, Issue 2, pp. 253 - 266
Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein... 
MEDICINE, RESEARCH & EXPERIMENTAL | SERINE BIOSYNTHESIS | GAMMA-GLUTAMATE SYNTHETASE | ESCHERICHIA-COLI | NUTRITIONAL SCIENCE | BINDING-PROTEIN | NEURAL-TUBE | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | IMMUNOLOGY | FOLIC-ACID | MAMMALIAN-CELLS | ONE-CARBON METABOLISM | 321 | Reviews
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 2, pp. 549 - 554
Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link... 
Enzymes | Phenotypes | Mitochondria | Dams | Sodium | Exons | Neural tube defects | Alleles | Formates | Embryos | CELLS | MESSENGER-RNA | MOUSE MUTANTS | RAT EMBRYOS | MULTIDISCIPLINARY SCIENCES | DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE | METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE | CLOSURE | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | FOLIC ACID METABOLISM | KNOCKOUT MICE | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Aminohydrolases - deficiency | Embryonic Development - genetics | Formate-Tetrahydrofolate Ligase - deficiency | Neural Tube Defects - genetics | Genotype | Immunoblotting | DNA Primers - genetics | Multienzyme Complexes - genetics | Aminohydrolases - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Multienzyme Complexes - deficiency | Animals | Formates - pharmacology | Gene Deletion | Formate-Tetrahydrofolate Ligase - genetics | Metabolic Networks and Pathways - physiology | Mice | Embryonic Development - drug effects | Formates - administration & dosage | Abnormalities, Multiple - genetics | Craniofacial Abnormalities - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Embryonic development | Phenotype | Neural tube | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Biochemistry | Rodents | Biological Sciences
Journal Article
Cancer Research, ISSN 0008-5472, 02/2017, Volume 77, Issue 4, pp. 937 - 948
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2014, Volume 289, Issue 22, pp. 15507 - 15517
Journal Article
Annual Review of Nutrition, ISSN 0199-9885, 7/2016, Volume 36, Issue 1, pp. 369 - 388
Journal Article