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Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 7/2012, Volume 18, Issue 13, pp. 3603 - 3615
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2016, Volume 34, Issue 30, pp. 3638 - 3647
Purpose By applying the principles of real-time biopsy, biomarker-based, adaptively randomized studies in non-small-cell lung cancer (NSCLC) established by the... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRIAL | MULTICENTER | AKT INHIBITOR MK-2206 | ONCOLOGY | EFFICACY | RESISTANCE | PHASE-II | SORAFENIB | DOCETAXEL | Thor12 | ORIGINAL REPORTS | Thor5 | To20
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 4/2014, Volume 20, Issue 8, pp. 2226 - 2235
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 6/2016, Volume 22, Issue 11, pp. 2659 - 2667
Journal Article
Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 12, pp. 3573 - 3585
The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream signaling influences cell... 
CELL LUNG-CANCER | AFURESERTIB | EFFICACY | RESISTANCE | PHASE-II | MK-2206 | CHEMISTRY, MULTIDISCIPLINARY | CYSTEINE PROTEASES | ARQ 092 | DISCOVERY | RATIONAL DESIGN
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 1727 - 1741
This study aimed to explore the neuroprotective effect of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein on early brain injury caused by... 
flow cytometry | transmission electron microscopy | neurofunctions | neuronal apoptosis | PRIMATE MODEL | APOPTOSIS | VASOSPASM | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITOR MK-2206 | ISCHEMIA | RAT MODEL | CELL-DEATH | MANF | CELL BIOLOGY | NECROSIS | CEREBRAL-ARTERY OCCLUSION | BIOLOGY
Journal Article
Pediatric Blood & Cancer, ISSN 1545-5009, 07/2014, Volume 61, Issue 7, pp. 1246 - 1251
Journal Article
Cell Cycle, ISSN 1538-4101, 08/2018, Volume 17, Issue 16, pp. 2069 - 2079
Breast cancer is a common type of cancer among female cancer patients and the main cause of cancer-related deaths. During the last decades, targeted therapies... 
targeted therapy | MK-2206 | neddylation | Breast cancer | AKT inhibitor | MLN4924 | ACTIVATION | BETA-TRCP | CELL BIOLOGY | CULLIN-RING LIGASES | IN-VITRO | MOLECULAR PORTRAITS | THERAPY | DEPTOR | RESISTANCE | MTOR INHIBITOR
Journal Article
by Jin PP and Wong CC and Mei SB and He XK and Qian Y and Sun LM
OncoTargets and Therapy, ISSN 1178-6930, 07/2016, Volume 2016, Issue Issue 1, pp. 4387 - 4396
Piaopiao Jin,1,2 Chi Chun Wong,3 Sibin Mei,1 Xingkang He,4 Yun Qian,4 Leimin Sun1 1Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang... 
gastric cancer | MK-2206 | apoptosis | Akt pathway | chemotherapy | caspase
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5759 - 8
An activated AKT pathway underlies the pathogenesis of soft tissue sarcoma (STS), with over-expressed phosphorylated AKT (p-AKT) correlating with a poor... 
1ST-LINE TREATMENT | EFFICACY | PATHWAY | MULTIDISCIPLINARY SCIENCES | DOXORUBICIN | DRUGS | PHASE-II | MK-2206 | CANCER | Cdc2 protein | Sarcoma | Cyclin-dependent kinases | Liposarcoma | Soft tissue sarcoma | Caspase | Cytotoxicity | AKT protein | Breast cancer | Cyclins | Metastases | Apoptosis
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2018, Volume 356, pp. 151 - 158
PIKfyve phosphoinositide kinase produces PtdIns(3,5)P and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell... 
PIKfyve | Cytotoxicity | MK-2206 | AKT | Ppilimod | YM201636 | ACTIVATION | COMPLEX | PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE | KINASE | PTDINS(3,5)P-2 | ISOLATED RAT HEPATOCYTES | AUTOPHAGOSOMES | PROTEIN-DEGRADATION | PTDINS5P | 3,5-BISPHOSPHATE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Physiological aspects | Medical colleges | Index Medicus
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2018, Volume 118, Issue 11, pp. 1464 - 1475
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 2018, Volume 14, Issue 13, pp. 1769 - 1781
Despite the high incidence of BRCA1-mutant breast cancer, few substantial improvements in preventing or treating such cancers have been made. Using a... 
MK-2206 | AKT | BRCA1 | Precision medicine | APOPTOSIS | ACTIVATION | BRCA1-DEFICIENT CELLS | INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | BREAST-CANCER | GENE | PATHWAY | precision medicine | EXPRESSION | Index Medicus
Journal Article
Cancer research, ISSN 0008-5472, 4/2011, Volume 71, Issue 7, pp. 2654 - 2663
Inhibition of the survival kinase Akt can trigger apoptosis but also has been found to activate autophagy, which may confound tumor attack. In this study, we... 
MK-2206 | Akt | Elongation factor-2 kinase | Autophagy | Glioblastoma | Apoptosis
Journal Article