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Clinical Infectious Diseases, ISSN 1058-4838, 12/2014, Volume 59, Issue 12, pp. 1675 - 1677
Journal Article
Lancet, The, ISSN 0140-6736, 2015, Volume 386, Issue 10003, pp. 1537 - 1545
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 03/2019, Volume 74, Issue 3, pp. 710 - 717
Abstract Background Elbasvir/grazoprevir is a once-daily fixed-dose combination therapy for the treatment of chronic HCV infection, including HCV/HIV... 
INFECTIOUS DISEASES | MK-8742 | HEPATITIS-C VIRUS | TRANSPORTERS | MK-5172 | COINFECTION | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | DISPOSITION
Journal Article
Organic Letters, ISSN 1523-7060, 11/2017, Volume 19, Issue 21, pp. 5880 - 5883
A practical and asymmetric synthesis of a functionalized trans-cyclo-propoxy building block for the preparation of the HCV NS3/4a protease inhibitor... 
PROTEASE INHIBITOR | STEREOSELECTIVE CYCLOPROPANATION | CATALYSIS | ALKENES | ETHERS | DIASTEREOSELECTIVE SYNTHESIS | STEREOCHEMISTRY | MK-5172 | CHEMISTRY, ORGANIC | SAFE
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 07/2015, Volume 163, Issue 1, pp. 1 - 13
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2015, Volume 373, Issue 8, pp. 714 - 725
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 11/2016, Volume 165, Issue 9, pp. 625 - 634
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2015, Volume 59, Issue 11, pp. 6922 - 6929
Elbasvir is an investigational NS5A inhibitor with in vitro activity against multiple HCV genotypes. Antiviral activity of elbasvir was measured in replicons... 
MK-8742 | EFFICACY | GRAZOPREVIR MK-5172 | SAFETY | COMBINATION THERAPY | RESISTANCE | ANTIVIRAL ACTIVITY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | PHASE-2 | RIBAVIRIN | Hepacivirus - drug effects | Humans | Middle Aged | Hepacivirus - genetics | Benzofurans - pharmacology | Genotype | Male | Imidazoles - pharmacology | Young Adult | Adolescent | Adult | Female | Replicon - genetics | Antiviral Agents
Journal Article
American Journal of Gastroenterology, ISSN 0002-9270, 06/2018, Volume 113, Issue 6, pp. 863 - 871
OBJECTIVES: Although direct-acting antiviral regimens have dramatically improved the treatment of hepatitis C virus (HCV) infection, there is some evidence... 
TREATMENT-NAIVE | EFFICACY | GRAZOPREVIR MK-5172 | SAFETY | COMBINATION THERAPY | TREATMENT-EXPERIENCED PATIENTS | GENOTYPE 1 INFECTION | ELBASVIR MK-8742 | RIBAVIRIN | GASTROENTEROLOGY & HEPATOLOGY | PEGINTERFERON | Clinical trials | Hepatitis | Infections | Interferon
Journal Article
JOURNAL OF VIRAL HEPATITIS, ISSN 1352-0504, 05/2018, Volume 25, Issue 5, pp. 457 - 464
People with hepatitis C virus (HCV) infection other than genotype 1 represent a heterogeneous group. The aim of the phase 2 C-SCAPE study was to evaluate... 
clinical trial | INFECTIOUS DISEASES | PLUS RIBAVIRIN | ribavirin | MK-8742 | COMBINATION THERAPY | SOFOSBUVIR | MK-5172 | hepatitis | elbasvir | HCV INFECTION | TRIAL | TREATMENT-NAIVE | VIROLOGY | TREATMENT-EXPERIENCED PATIENTS | grazoprevir | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2016, Volume 138, Issue 36, pp. 11850 - 11859
Hepatitis C virus (HCV), affecting an estimated 150 million people worldwide, is the leading cause of viral hepatitis, cirrhosis and hepatocellular carcinoma.... 
POTENT | CRYSTAL-STRUCTURE | STRUCTURAL-ANALYSIS | SUSCEPTIBILITY | MK-5172 | RIBAVIRIN | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | EPIDEMIOLOGY | SUBSTRATE RECOGNITION | Molecular simulation | Usage | Molecular dynamics | Chemical properties | Research | Diagnosis | Structure | Drug resistance | Hepatitis C | Chemical compounds
Journal Article
JOURNAL OF VIRAL HEPATITIS, ISSN 1352-0504, 10/2016, Volume 23, Issue 10, pp. 789 - 797
Grazoprevir (GZR) is a second-generation hepatitis C virus NS3/4A protease inhibitor. The aim of this study was to evaluate GZR plus ribavirin (RBV) in... 
clinical trial | TRIAL | INFECTIOUS DISEASES | VIROLOGY | COMBINATION THERAPY | MK-5172 | adverse event | PHASE-2 | GASTROENTEROLOGY & HEPATOLOGY | randomized | efficacy | resistance
Journal Article