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biochemistry & molecular biology (5) 5
index medicus (5) 5
mapk, mitogen-activated protein kinase (5) 5
animals (4) 4
cell line (4) 4
erk, extracellular-signal-regulated kinase (4) 4
humans (4) 4
jnk, c-jun n-terminal kinase (4) 4
mkk1, mapk kinase-1 (4) 4
phosphorylation (4) 4
pkb, protein kinase b (4) 4
research article (4) 4
egf, epidermal growth factor (3) 3
enzyme activation (3) 3
gst, glutathione s-transferase (3) 3
life sciences (3) 3
lps, lipopolysaccharide (3) 3
ph, pleckstrin homology (3) 3
pi3k, phosphoinositide 3-kinase (3) 3
rsk, p90 ribosomal s6 kinase (3) 3
amino acid sequence (2) 2
base sequence (2) 2
cdk, cyclin-dependent protein kinase (2) 2
cells (2) 2
enzyme inhibitors - pharmacology (2) 2
gak, cyclin g-associated kinase (2) 2
gsk3, glycogen synthase kinase 3 (2) 2
identification (2) 2
igf-1, insulin-like growth factor-1 (2) 2
in-vivo (2) 2
kestrel, kinasesubstrate tracking and elucidation (2) 2
kinase substrate tracking and elucidation (2) 2
msk, mitogen- and stress-activated protein kinase (2) 2
p38 map kinase (2) 2
p90 ribosomal s6 kinase (2) 2
pdk1, 3-phosphoinositide-dependent kinase 1 (2) 2
pkc, protein kinase c (2) 2
protein kinase b (2) 2
protein kinase inhibitors - pharmacology (2) 2
rats (2) 2
ribosomal protein s6 kinases, 90-kda - metabolism (2) 2
rip2, receptor-interacting protein 2 (2) 2
rock, rho-dependent protein kinase (2) 2
serum (2) 2
sgk, serum- and glucocorticoid-induced kinase (2) 2
tnf, tumour necrosis factor (2) 2
acetylmuramyl-alanyl-isoglutamine - metabolism (1) 1
acetylmuramyl-alanyl-isoglutamine - pharmacology (1) 1
activated protein-kinase (1) 1
activation (1) 1
adaptive immune-responses (1) 1
agc, camp-dependent protein kinase (1) 1
aicar, aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (1) 1
ampk, amp-activated protein kinase (1) 1
anti-cancer drugs (1) 1
are, au-rich element (1) 1
atf2, activating transcription factor 2 (1) 1
atm, ataxia telangiectasia mutated (1) 1
bi-d1870 (1) 1
bi-di870 (1) 1
biochemistry - methods (1) 1
brain (1) 1
brsk, brain-specific kinase (1) 1
cak, cyclin-dependent kinase-activating kinase (1) 1
calcium-regulated heat-stable protein of 24 kda (1) 1
camk, calmodulin-dependent kinase (1) 1
camkk, camk kinase (1) 1
capzip, capz-interacting protein (1) 1
catalysis (1) 1
cdk2–a, cyclin-dependent kinase 2 complexed with cyclin a (1) 1
cell-proliferation (1) 1
chk, checkpoint kinase (1) 1
chromones - pharmacology (1) 1
ck, casein kinase (1) 1
ck1, casein kinase-1 (1) 1
ck1, ‘casein kinase 1’ (1) 1
cold-shock domain (1) 1
creb (1) 1
creb, camp-response-element-binding protein (1) 1
crhsp24, calcium-regulated heat-stable protein of 24 kda (1) 1
crhsp24, calcium-regulated heatshock protein of 24 kda (1) 1
crmp, collapsin-response mediator protein (1) 1
crohns-disease (1) 1
csd, cold-shock domain (1) 1
csk, c-terminal src kinase (1) 1
cyclin-dependent kinases (1) 1
cytokines - biosynthesis (1) 1
dna primers (1) 1
dna-binding proteins - metabolism (1) 1
domain (1) 1
drug design (1) 1
drug discovery (1) 1
dyrk, dual-specificity tyrosine-phosphorylated and -regulated kinase (1) 1
dyrk, dual-specificity tyrosine-phosphorylated and -regulated protein kinase (1) 1
dyrk1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a (1) 1
ef2, elongation factor 2 (1) 1
ef2k, ef2 kinase (1) 1
ef2k, elongation-factor-2 kinase (1) 1
eph-a2, ephrin a2 receptor (1) 1
erk1, extracellular-signal-regulated kinase 1 (1) 1
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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 179 - 190
MDP (muramyl dipeptide), a component of peptidoglycan, interacts with NOD2 (nucleotide-binding oligomerization domain 2) stimulating the NOD2-RIP2... 
Pro-inflammatory cytokines | Nucleotide-binding oligomerization domain 2 (NOD2) | Muramyl dipeptide (MDP) | Receptor-interacting protein 2 (RIP2) | Transforming-growth-factor-β-activated kinase-1 (TAK1) | ACTIVATION | CROHNS-DISEASE | muramyl dipeptide (MDP) | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOD2 | P38 MAP KINASE | nucleotide-binding oligomerization domain 2 (NOD2) | TAK1 | pro-inflammatory cytokines | transforming-growth-factor-beta-activated kinase-1 (TAK1) | IN-VIVO | receptor-interacting protein 2 (RIP2) | FRAMESHIFT MUTATION | NF-KAPPA-B | ADAPTIVE IMMUNE-RESPONSES | PROTEIN-KINASE INHIBITORS | Cell Line | Signal Transduction | Humans | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | DNA Primers | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Nod2 Signaling Adaptor Protein - metabolism | Base Sequence | Interleukin-1beta - biosynthesis | Pyridines - pharmacology | Catalysis | Enzyme Activation | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Interleukin-1beta - antagonists & inhibitors | Index Medicus | KI, kinase inactive | CK1, ‘casein kinase 1’ | TLR, Toll-like receptor | WT, wild-type | TNF, tumour necrosis factor | HEK-293, human embryonic kidney 293 cells | JNK, c-Jun N-terminal kinase | MDP, muramyl dipeptide | TAK1, transforming-growth-factor-β-activated kinase-1 | transforming-growth-factor-β-activated kinase-1 (TAK1) | ERK, extracellular-signal-regulated kinase | K63-pUb, Lys63-linked polyubiquitin | RIP2, receptor-interacting protein 2 | MKK1, MAPK kinase-1 | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | GAK, cyclin G-associated kinase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | IKKβ, inhibitor of nuclear factor κB kinase β | GST, glutathione S-transferase | NF-κB, nuclear factor κB | NEMO, nuclear factor κB essential modifier | HA, haemagglutinin | NOD, nucleotide-binding oligomerization domain | TRAF6, TNF-receptor-associated factor 6 | M-TriDAP, muramyl-N-acetyl-L-Ala-D-Glu-m-diaminopimelic acid | IL, interleukin | LPS, lipopolysaccharide | shRNA, short hairpin RNA | VSV-G, vesicular-stomatitis-virus envelope glycoprotein | PBMCs, peripheral-blood mononuclear cells | Tpl2, tumour progression locus 2 | FCS, foetal-calf serum | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2006, Volume 393, Issue 1, pp. 1 - 6
The identification of all the substrates of every protein kinase is one of the major challenges of post-genomic research. Here we review a powerful method for... 
Mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | Protein kinase B (PKB) | Glycogen synthase kinase 3 (GSK3) | Serum- and glucocorticoid-induced protein kinase (SGK) | Kinase substrate tracking and elucidation (KESTREL) | CELLS | glycogen synthase kinase 3 (GSK3) | DOMAIN | SPECIFICITY | PHOSPHORYLATION | PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM | IDENTIFICATION | IN-VITRO | protein kinase B (PKB) | kinase substrate tracking and elucidation (KESTREL) | mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) | TRANSFER-RNA | STRESS | serum- and glucocorticoid-induced protein kinase (SGK) | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Reproducibility of Results | Animals | Peptide Mapping | Biochemistry - methods | Substrate Specificity | Protein Kinases - deficiency | Index Medicus | CRMP, collapsin-response mediator protein | PI3K, phosphoinositide 3-kinase | SAKS1, SAPK-substrate 1 | TNF, tumour necrosis factor | hnRNP, heterogeneous nuclear ribonucleoprotein | PNGase, peptide N-glycanase | PDK1, 3-phosphoinositide-dependent kinase 1 | HEK, human embryonic kidney | Review | JNK, c-Jun N-terminal kinase | EF2, elongation factor 2 | UBA, ubiquitin-associated | KSHV, Kaposi sarcoma-associated herpesvirus | UBX, ubiquitin-like | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | SAPK, stress-activated protein kinase | MKK1, MAPK kinase-1 | EF2K, EF2 kinase | HSP27, heat-shock protein of 27 kDa | METTL1, methyltransferase-like protein 1 | FLNc, filamin C | NDRG, N-myc downstream-regulated gene product | VCP, valosin-containing protein | GSK3, glycogen synthase kinase 3 | SGK, serum- and glucocorticoid-induced protein kinase | IGF-1, insulin-like growth factor 1 | KESTREL, kinasesubstrate tracking and elucidation | MAPKAP-K2, MAPK-activated protein kinase-2 | CDK, cyclin-dependent protein kinase | CRHSP24, calcium-regulated heatshock protein of 24 kDa | PIC, pro-inflammatory cytokine | LPS, lipopolysaccharide | ARE, AU-rich element | CapZIP, CapZ-interacting protein | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 389, Issue 3, pp. 775 - 783
A substrate for PKB alpha (protein kinase B alpha) was detected in liver extracts, and was purified and identified as CRHSP24 (calcium-regulated heat-stable... 
Protein kinase B (PKB) | p90 ribosomal S6 kinase (RSK) | Calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | Kinase substrate tracking and elucidation (KESTREL) | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM | P70 S6 KINASE | RNA-BINDING PROTEIN | PIPPIN | calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | IN-VIVO | protein kinase B (PKB) | COLD-SHOCK DOMAIN | MAPKAP KINASE-1 | kinase substrate tracking and elucidation (KESTREL) | BRAIN | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Liver - enzymology | Humans | Molecular Sequence Data | Rats | Phosphoproteins - metabolism | Rats, Sprague-Dawley | Sequence Homology, Nucleic Acid | DNA-Binding Proteins - metabolism | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Base Sequence | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | EST, expressed sequence tag | HEK-293, human embryonic kidney | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | FCS, foetal calf serum | MNK, MAPK-integrating kinase | IGF-1, insulin-like growth factor-1 | calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | STYX, serine | CSD, cold-shock domain | DYRK, dual-specificity tyrosine-phosphorylated and -regulated protein kinase | GST, glutathione S-transferase | PP, protein phosphatase | KESTREL, kinasesubstrate tracking and elucidation | PH, pleckstrin homology | S6K, p70 ribosomal protein S6 kinase | threonine | CRHSP24, calcium-regulated heat-stable protein of 24 kDa | MKK1, MAPK kinase 1 | tyrosine-interacting protein | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
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