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mkk7 (109) 109
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06/2011
The Liver X Receptor (LXR) and Pregnane X Receptor (PXR) are members of the nuclear receptor superfamily. Previously, they have been classified as important... 
transcription factor | homeostasis | c-Jun | inflammation | Akt | MKK7
Web Resource
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, ISSN 0141-8130, 07/2018, Volume 114, pp. 114 - 123
GADD45 beta is selectively and constitutively expressed in Multiple Myeloma cells, and this expression correlates with an unfavourable clinical outcome. GADD45... 
Chemical cross-linking | SURVIVAL | POLYMER SCIENCE | GADD45 beta | Protein-protein interaction | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MKK7 | PROTEIN INTERACTIONS | BINDS | MKK7/JNKK2 | CHEMISTRY, APPLIED | MAP2K7 | Mass spectrometry | NF-KAPPA-B | CYS218
Journal Article
Oncogene, ISSN 0950-9232, 10/2008, Volume 27, Issue 48, pp. 6245 - 6251
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2014, Volume 26, Issue 4, pp. 495 - 508
Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell... 
MULTIPLE-MYELOMA | CELLS | ACTIVATION | MKK7/JNKK2 | ONCOLOGY | SIGNALING PATHWAY | INFLAMMATION | KINASE | BORTEZOMIB | PROTEASOME INHIBITOR | EXPRESSION | CELL BIOLOGY
Journal Article
Apmis, ISSN 0903-4641, 07/2008, Volume 116, Issue 7, pp. 586 - 601
Horak CE, Lee JH, Marshall JC, Shreeve SM, Steeg PS. The role of metastasis suppressor genes in metastatic dormancy. APMIS 2008;116:586-601. Metastasis... 
Dormancy | KISS1 | MKK4 | metastasis | Nm23 | metastasis suppressor gene | KAI1 | MKK7 | Metastasis suppressor gene | Metastasis
Journal Article
International Journal of Biological Macromolecules, ISSN 0141-8130, 07/2018, Volume 114, pp. 114 - 123
GADD45β is selectively and constitutively expressed in Multiple Myeloma cells, and this expression correlates with an unfavourable clinical outcome. GADD45β... 
Chemical cross-linking | GADD45β | Protein-protein interaction | Mass spectrometry | MKK7
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 7/2018, Volume 55, Issue 7, pp. 5976 - 5992
HIV-1-associated neurocognitive disorders (HAND) is associated with blood-brain-barrier (BBB) inflammation, and inflammation involves toll-like receptors... 
HIV-1 | Neurosciences | Neurobiology | Claudin-5 | TAK1/MKK7/JNK signaling | Human brain microvascular endothelial cells | Cell Biology | Neurology | IL6 | Monocytes | Biomedicine | Blood-brain barrier | TLR3 | TRANSCRIPTION FACTORS | BARRIER DYSFUNCTION | CELLS | DOUBLE-STRANDED-RNA | ACTIVATION | NEUROSCIENCES | CENTRAL-NERVOUS-SYSTEM | HIV-1 INFECTION | C-JUN | NF-KAPPA-B | INNATE IMMUNITY | Phosphorylation | Humans | Middle Aged | Male | RNA, Messenger - metabolism | MAP Kinase Signaling System | HIV-1 - physiology | HIV Infections - pathology | Adult | Female | Transcription, Genetic | RNA, Double-Stranded - metabolism | Toll-Like Receptor 3 - genetics | Endothelial Cells - virology | Interleukin-6 - metabolism | Interleukin-6 - genetics | Endothelial Cells - metabolism | HIV Infections - genetics | RNA, Messenger - genetics | Up-Regulation - genetics | MAP Kinase Kinase Kinases - metabolism | Toll-Like Receptor 3 - metabolism | Models, Biological | Brain - pathology | Ligands | Aged | Endothelial Cells - pathology | Prevention | Brain | Interleukins | DNA binding proteins | HIV (Viruses) | Endothelium | Neuropathogenesis | Transcription factors | Leukocyte migration | Serine | Cognition | Blood | Interleukin 6 | Cell activation | Acquired immune deficiency syndrome--AIDS | Transcription activation | Human immunodeficiency virus--HIV | Interleukin 1 | Toll-like receptors | Stat1 protein | Cytokines | TAK1 protein | Blood vessels | c-Jun protein | Inflammation | Hand | Adhesion | TLR3 protein | Endothelial cells | Microvasculature | ATP | blood-brain barrier | monocytes | TAK1 | JNK signaling | human brain microvascular endothelial cells | MKK7 | claudin-5
Journal Article
by Ba, F and Zhou, YX and Zhou, J and Chen, XY
MOLECULAR AND CELLULAR BIOCHEMISTRY, ISSN 0300-8177, 08/2019, Volume 458, Issue 1-2, pp. 71 - 78
Repetitive transcranial magnetic stimulation (rTMS) is a technique protecting neurons against diverse neurodegenerative disorders by delivering magnetic... 
PRESENILIN | APP | BETA-SECRETASE ACTIVITY | Parkinson's disease | SIGNS | TRANSCRIPTION | NICASTRIN | A beta(1-42) | Repetitive transcranial magnetic stimulation | MKK7 | CELL BIOLOGY | BACE1 | CEREBROSPINAL-FLUID BIOMARKERS | MOTOR CORTEX | GAMMA-SECRETASE
Journal Article
Brain Research, ISSN 0006-8993, 07/2018, Volume 1691, pp. 1 - 8
JNK, a member of the mitogen activated protein kinases (MAPKs) superfamily, plays a key role in cell death in many neurological disorders, but systemic... 
ER stress | Mitochondrial dysfunction | Wnt | JNK | MKK7 | TARGET | NERVOUS-SYSTEM | ACTIVATION | INDUCED APOPTOSIS | BRAIN-INJURY | NEURODEGENERATION | TOXICITY | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | CHOP | CEREBRAL-ISCHEMIA | Index Medicus
Journal Article
Plant Science, ISSN 0168-9452, 10/2019, Volume 287, p. 110190
Phosphatidic acid (PA) is a lipid secondary messenger involved in intracellular signaling in eukaryotes. It has been confirmed that PA mediates salt stress... 
MKK9 | Salt stress | MAPK cascade | Arabidopsis | MKK7 | Phosphatidic acid | ARABIDOPSIS-THALIANA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MPK6 | MAPK | PLANT SCIENCES | RAF-1 KINASE | ETHYLENE | PROTEIN-KINASE CASCADE | ARCHITECTURE | BINDING | CELL | EXPRESSION
Journal Article
Cell Death and Disease, ISSN 2041-4889, 07/2016, Volume 7, Issue 7, pp. e2306 - e2306
Journal Article
Journal Article
FRONTIERS IN PLANT SCIENCE, ISSN 1664-462X, 12/2017, Volume 8
Reversible protein phosphorylation is a widespread posttranslational modification that plays a key role in eukaryotic signal transduction. Due to the dynamics... 
MKK7 cascade | TARGET | ACTIVATED PROTEIN-KINASE | MPK6 | CASCADES | plant immunity and development | tandemMOAC | IDENTIFICATION | PLANT SCIENCES | Arabidopsis thaliana | THALIANA | mitogen-activated protein kinases | LEADS | DYNAMIN-RELATED PROTEINS | EXPRESSION
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 12/2017, Volume 8
Reversible protein phosphorylation is a widespread posttranslational modification that plays a key role in eukaryotic signal transduction. Due to the dynamics... 
Arabidopsis thaliana | MKK7 cascade | Plant immunity and development | TandemMOAC | Mitogen-activated protein kinases | Protein kinases | Cellular signal transduction | plant immunity and development | tandemMOAC | mitogen-activated protein kinases
Journal Article
Cancer prevention research (Philadelphia, Pa.), ISSN 1940-6207, 12/2013, Volume 6, Issue 12
Licorice root is known to possess various bioactivities, including anti-inflammatory and anticancer effects. Glycyrrhizin (Gc), a triterpene compound, is the... 
melanoma | MKK4 | PI3K | Isoangustone A | MKK7
Journal Article
International Journal of Cancer, ISSN 0020-7136, 11/2019, Volume 145, Issue 9, pp. 2496 - 2508
JNK activity has been implicated in the malignant proliferation, invasion and drug‐resistance of glioma cells (GCs), but the molecular mechanisms underlying... 
HDAC4 | glioma | KLF5 | SP1 | JNK | MKK7 | CELLS | N-TERMINAL KINASE | TUMORIGENICITY | IDENTIFICATION | NUCLEAR ACCUMULATION | ONCOLOGY | GROWTH | RESISTANCE | UP-REGULATION | EXPRESSION | AXIS | Drug resistance | Gliomas | Genetic transcription | Cell proliferation | Transcription factors | Xenotransplantation | Activation | Sp1 protein | Nuclear transport | Blockage | Signaling | Molecular modelling | Transcription activation | Glioma cells | Xenografts | Inhibition | Tumors
Journal Article