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PLoS ONE, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5622 - e5622
Background: The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human... 
INACTIVATION | MAMMALIAN TRITHORAX | DELAYED REPLICATION | METHYLATION | DOMAIN | GROUP GENE | MULTIDISCIPLINARY SCIENCES | METHYLTRANSFERASE ACTIVITY | MLL | CELLULAR SENESCENCE | HISTONE | NIH 3T3 Cells | Myeloid-Lymphoid Leukemia Protein - metabolism | Cellular Senescence | Repressor Proteins - metabolism | Fibroblasts - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Cycle Proteins - metabolism | Gene Silencing | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Nuclear Proteins - metabolism | Polycomb-Group Proteins | Enhancer of Zeste Homolog 2 Protein | Polycomb Repressive Complex 2 | Animals | Cyclin-Dependent Kinase Inhibitor p16 - chemistry | Polycomb Repressive Complex 1 | Histone-Lysine N-Methyltransferase - metabolism | Embryo, Mammalian - cytology | Models, Biological | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Protein Binding | DNA Replication Timing | Fibroblasts - cytology | Mice | Histones - metabolism | Methylation | Proteins | Epigenetic inheritance | DNA replication | Senescence | Chromatin | Genes | INK4a protein | Genomes | Recruitment | Cell growth | Transcription activation | Cell cycle | Fibroblasts | Cyclin-dependent kinase inhibitors | Deoxyribonucleic acid--DNA | p16 Protein | INK4 protein | Embryo fibroblasts | Gene expression | Embryos | Loci | DNA biosynthesis | Polycomb group proteins | Replication origins | Pilot projects | Insects | Stem cells | Epigenetics | Tumor suppressor genes | Replication | Embryo, Mammalian | Histone-Lysine N-Methyltransferase | Repressor Proteins | Cell Aging | Nuclear Proteins | Cyclin-Dependent Kinase Inhibitor p16 | Life Sciences | Immunology | Histones | Myeloid-Lymphoid Leukemia Protein | Proto-Oncogene Proteins | Cell Cycle Proteins | Deoxyribonucleic acid | DNA
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2019, Volume 62, Issue 24, pp. 11232 - 11259
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new... 
MYC/MAX DIMERIZATION | COMPLEX | METHYLATION | CHEMISTRY, MEDICINAL | RECOGNITION | STRUCTURAL BASIS | HIGH-AFFINITY | LINEAGE | BINDING | ASSOCIATION | LEUKEMIA MLL PROTEIN
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2018, Volume 57, Issue 6, pp. 1601 - 1605
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2013, Volume 33, Issue 10, pp. 2067 - 2077
Journal Article
Structure, ISSN 0969-2126, 01/2018, Volume 26, Issue 1, pp. 85 - 95.e3
The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities... 
histone methylation | DNMT1 | KDM2A | DNA methylation | TET1 | CFP1 | CpG island | MLL | CXXC domain | epigenetics | Epigenesis, Genetic | Humans | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | Mixed Function Oxygenases - chemistry | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Jumonji Domain-Containing Histone Demethylases - chemistry | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Jumonji Domain-Containing Histone Demethylases - genetics | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Protein Conformation, beta-Strand | Escherichia coli - genetics | CpG Islands | Protein Binding | Mixed Function Oxygenases - genetics | F-Box Proteins - genetics | Jumonji Domain-Containing Histone Demethylases - metabolism | Protein Isoforms - genetics | Epigenetic inheritance | Chromatin | Methyltransferases | DNA | Crystals | Physiological aspects | Genetic research | Nucleotide sequencing | Methylation | Structure | Protein binding | DNA sequencing
Journal Article
Leukemia, ISSN 0887-6924, 03/2017, Volume 31, Issue 10, pp. 2200 - 2210
Rearrangements involving the NUP98 gene resulting in fusions to several partner genes occur in acute myeloid leukemia and myelodysplastic syndromes. This study... 
TRANSFORMATION | STEM-CELLS | CHROMOSOME-TRANSLOCATION | MUTANT MICE | METHYLTRANSFERASE | ONCOLOGY | HOX GENE-EXPRESSION | ACUTE MYELOID-LEUKEMIA | NUP98 | HEMATOLOGY | MLL-AF9-INDUCED LEUKEMOGENESIS | NUCLEOPORIN GENE | Humans | Nuclear Pore Complex Proteins - chemistry | Myeloid-Lymphoid Leukemia Protein - deficiency | Histone-Lysine N-Methyltransferase - deficiency | Leukemia, Experimental - etiology | Gene Expression Regulation, Leukemic - genetics | Nuclear Pore Complex Proteins - genetics | Oncogene Proteins, Fusion - physiology | Nuclear Pore Complex Proteins - physiology | Oncogene Proteins, Fusion - chemistry | Transfection | Chromatin Immunoprecipitation | Myeloid-Lymphoid Leukemia Protein - physiology | Cell Transformation, Neoplastic - genetics | Protein Domains | Neoplasm Proteins - genetics | Leukemia, Experimental - genetics | Histone-Lysine N-Methyltransferase - genetics | Homeodomain Proteins - biosynthesis | Mutagenesis, Site-Directed | Neoplasm Proteins - biosynthesis | Mice, Inbred C57BL | Radiation Chimera | Homeodomain Proteins - chemistry | Homeodomain Proteins - genetics | Mice, Knockout | Protein Interaction Mapping | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Protein Binding | Mice | Myeloid Ecotropic Viral Integration Site 1 Protein | Homeodomain Proteins - physiology | Histone-Lysine N-Methyltransferase - physiology | Transcription factors | Care and treatment | Leukemia | Development and progression | Genetic aspects | Gene expression | Health aspects | Oncogenes | NUP98 gene | Myeloid leukemia | Immortalization | Leukemogenesis | HOXA gene | Cell immortalization | Fusion protein | Acute myeloid leukemia | Myelodysplastic syndrome | Recruitment
Journal Article
Biochemical Society Symposium, ISSN 0067-8694, 06/2013, Volume 41, Issue 3, pp. 727 - 740
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates... 
DNA methylation | Epigenetics | DNA demethylation | Chromatin | Transcription | CpG island | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | TRANSCRIPTIONAL REPRESSION | chromatin | H3-LYS METHYLTRANSFERASE COMPLEX | epigenetics | FINGER PROTEIN-1 | EMBRYONIC STEM-CELLS | MIXED-LINEAGE-LEUKEMIA | GENOME-WIDE ANALYSIS | POSTNATAL-DEVELOPMENT | HISTONE H3 ACETYLATION | Amino Acid Sequence | Chromatin - metabolism | DNA-Binding Proteins - physiology | Humans | Models, Molecular | Molecular Sequence Data | DNA Methylation - genetics | Protein Structure, Tertiary - genetics | DNA - metabolism | CpG Islands - physiology | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | CpG Islands - genetics | Zinc Fingers - genetics | DNA Methylation - physiology | Protein Binding - physiology | MBD, methyl-CpG-binding domain | PRC, polycomb group repressive complex | IDAX, inhibition of the Dvl and axin complex protein | ESC, embryonic stem cell | RING, really interesting new gene | CFP1, CxxC finger protein 1 | JmjC, Jumonji C | PHD, plant homeodomain | Biochemical Society Annual Symposium No. 80 | 5mC, 5-methylcytosine | CGBP, CpG-binding protein | 5hmC, 5-hydroxymethylcytosine | DNMT1, DNA methyltransferase 1 | FBXL19, F-box and leucine-rich repeat protein 19 | RFTS, replication foci-targeting sequence | WDR, WD40 repeat | DPY-30, dosage compensation protein 30 | AF9, ALL1–fused gene from chromosome 9 protein | ChIP-seq, chromatin immunoprecipitation sequencing | HDAC, histone deacetylase | YY1, Yin and Yang 1 | RbBP5, retinoblastoma-binding protein 5 | ZF-CxxC, zinc finger-CxxC | BAH, bromo-adjacent homology | ASH2L, absent, small or homeotic 2-like | SETD1, SET domain 1 | TET, ten-eleven translocation | SEC, super-elongation complex | MLL, mixed lineage leukaemia protein | CGI, CpG island | ENL, eleven-nineteen leukaemia | shRNA, short hairpin RNA | KDM, lysine demethylase | RNAPII, RNA polymerase II
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e16627
Several mammalian proteins involved in chromatin and DNA modification contain CXXC zinc finger domains. We compared the structure and function of the CXXC... 
MAINTENANCE | METHYLATION | DNA CYTOSINE-5 METHYLTRANSFERASE | PROTEIN | REPLICATION | MAMMALIAN DNA | GENE | MULTIDISCIPLINARY SCIENCES | CATALYTIC DOMAIN | ACUTE MYELOID-LEUKEMIA | MLL | DNA (Cytosine-5-)-Methyltransferases - physiology | Protein Binding - genetics | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - chemistry | DNA (Cytosine-5-)-Methyltransferases - chemistry | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | DNA Methylation - physiology | Proto-Oncogene Proteins - metabolism | DNA-Binding Proteins - physiology | Mutagenesis, Site-Directed | Sequence Deletion - physiology | DNA (Cytosine-5-)-Methyltransferase 1 | Cells, Cultured | Models, Molecular | Proto-Oncogene Proteins - genetics | Amino Acid Sequence - physiology | Protein Structure, Tertiary - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Sequence Homology, Amino Acid | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Proto-Oncogene Proteins - physiology | CpG Islands - genetics | Zinc Fingers - genetics | Mice | Zinc Fingers - physiology | Enzyme Activation - genetics | Enzyme Activation - physiology | Protein Binding - physiology | Protein Structure, Tertiary - physiology | Pyrimidines | Methyltransferases | Analysis | DNA | DNA binding proteins | Methylation | Embryonic stem cells | DNA-ligand interactions | Chromatin | Genes | Embryo cells | Science | Homology | Genomes | Biology | Catalytic activity | Proteins | DNA methylation | Physiology | Cytosine | Zinc finger proteins | Catalysis | Coordination compounds | Deoxyribonucleic acid--DNA | CpG islands | Binding | Dioxygenase | Enzymes | Construction | Nucleotide sequence | DNMT1 protein | Mammals | Substrates | Zinc | Algorithms | Mutagenesis | Stem cells | Epigenetics | DNA methyltransferase | Mutation | Structure-function relationships | Deoxyribonucleic acid
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 597 - 608
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for... 
CELLCYCLE | CELLS | LEUKEMIC TRANSFORMATION | PROTEIN | ONCOLOGY | SYNTHASE KINASE 3-BETA | MYELOID-LEUKEMIA | MLL | EXPRESSION | BINDING | CANCER | HOMEOBOX GENE CDX2 | CELL BIOLOGY | Transcription, Genetic - drug effects | Neoplastic Stem Cells - cytology | Neoplastic Stem Cells - drug effects | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Profiling | CREB-Binding Protein - metabolism | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Protein Binding - drug effects | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Leukemia, Myeloid, Acute - prevention & control | Down-Regulation - genetics | Gene Expression Regulation, Leukemic - physiology | Cyclic AMP Response Element-Binding Protein - genetics | Glycogen Synthase Kinase 3 - genetics | Signal Transduction - drug effects | Models, Biological | Cell Line, Tumor | Indoles - therapeutic use | Proto-Oncogene Proteins c-fos - genetics | Mice | Myeloid Ecotropic Viral Integration Site 1 Protein | Protein Binding - physiology | Phosphorylation - physiology | Maleimides - pharmacology | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Maleimides - therapeutic use | Indoles - pharmacology | Pre-B-Cell Leukemia Transcription Factor 1 | Proto-Oncogene Proteins - metabolism | Mice, Inbred C57BL | Proto-Oncogene Proteins c-fos - metabolism | Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Cell Transformation, Neoplastic - metabolism | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Transcription, Genetic - physiology | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | Cell Proliferation - drug effects | Pharmaceutical industry | Leukemia | Stem cells
Journal Article