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Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 2017, Volume 56, Issue 40, pp. 12170 - 12173
Mobile proton-containing solutes can be detected by MRI by the chemical exchange saturation transfer (CEST) method. CEST sensitivity is dramatically enhanced... 
magnetic resonance imaging | chemical shift | MMP-2 | paramagnetic liposomes | LipoCEST | Biotin - chemistry | Streptavidin - chemistry | Liposomes - chemistry | Proteolysis | Surface Properties | Water - chemistry | Phospholipids - chemistry | Matrix Metalloproteinase 2 - chemistry | Proton Magnetic Resonance Spectroscopy - methods
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2017, Volume 56, Issue 40, pp. 12170 - 12173
Mobile proton‐containing solutes can be detected by MRI by the chemical exchange saturation transfer (CEST) method. CEST sensitivity is dramatically enhanced... 
magnetic resonance imaging | chemical shift | MMP-2 | paramagnetic liposomes | LipoCEST | Measurement | Lipids | Biotin | Biopharmaceutics
Journal Article
Sensors and Actuators: B. Chemical, ISSN 0925-4005, 11/2018, Volume 273, pp. 511 - 518
•A programmed nanosensor is developed to realize in situ imaging monitoring of intracellular MMP-2.•This nanosensor utilized MSN to assemble wrapping... 
Intracellular MMP-2 | Programmed nanosensor | In situ monitoring | Microcapsule-type | CANCER-CELLS | ELECTROCHEMISTRY | FRET SENSOR | CHEMISTRY, ANALYTICAL | VIVO | TUMOR | ATHEROSCLEROSIS | MESOPOROUS SILICA NANOPARTICLES | INSTRUMENTS & INSTRUMENTATION | THERAPY | RELEASE DRUG-DELIVERY | EXPRESSION | LIVING CELLS
Journal Article
Journal of Drug Targeting, ISSN 1061-186X, 11/2019, Volume 27, Issue 10, pp. 1084 - 1093
Mesoporous silica nanoparticles (MSNs) have ideal characteristics as next generation of controlled drug delivery systems. In this study, a MSN-based... 
MMP-cleavable peptides | Stimuli-responsive nanocarriers | mesoporous silica nanoparticle | Enzyme-responsive nanocarriers | MATRIX | THERAPY IN-VITRO | HEMOCOMPATIBILITY | MMP-2 | DNA | SIZE | PHARMACOLOGY & PHARMACY | CONTROLLED DRUG-RELEASE
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 09/2017, Volume 56, Issue 40, pp. 12170 - 12173
Mobile proton-containing solutes can be detected by MRI by the chemical exchange saturation transfer (CEST) method. CEST sensitivity is dramatically enhanced... 
magnetic resonance imaging | MATRIX-METALLOPROTEINASE 2 | COMPLEXES | SENSITIVITY | RELAXATION | chemical shift | paramagnetic liposomes | CHEMISTRY, MULTIDISCIPLINARY | CANCER-PATIENTS | MMP-2 | TISSUE INHIBITOR | CEST | LipoCEST | MRI CONTRAST AGENTS
Journal Article
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 03/2019, Volume 9, Issue 2, pp. 381 - 396
Journal Article
Angewandte Chemie, ISSN 0044-8249, 09/2017, Volume 129, Issue 40, pp. 12338 - 12341
Mobile proton‐containing solutes can be detected by MRI by the chemical exchange saturation transfer (CEST) method. CEST sensitivity is dramatically enhanced... 
MMP-2 | LipoCEST | Kernspintomographie | Chemische Verschiebung | Paramagnetische Liposomen | Measurement | Lipids | Biotin | Analysis | Biopharmaceutics
Journal Article
ACS Nano, ISSN 1936-0851, 09/2017, Volume 11, Issue 9, pp. 8668 - 8678
During pancreatic tumor development, pancreatic stellate cells (PSCs) proliferate exuberantly to secrete extracellular matrix (ECM) in the tumor stroma, which... 
enhanced pancreatic tumor therapy | pancreatic stellate cells | peptide-hybrid liposome | down-regulation of ECM | MMP-2 responsive | CARCINOMA-CELLS | FIBROSIS | MATERIALS SCIENCE, MULTIDISCIPLINARY | STELLATE CELLS | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CANCER MICROENVIRONMENT | IDENTIFICATION | CULTURE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | STROMAL BIOLOGY | IN-VIVO | ULTRASOUND-TRIGGERED RELEASE | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Stellate Cells - drug effects | Extracellular Matrix - metabolism | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Pancreatic Neoplasms - drug therapy | Pyridones - administration & dosage | Deoxycytidine - pharmacokinetics | Deoxycytidine - therapeutic use | Peptides - metabolism | Antineoplastic Agents - pharmacokinetics | Tumor Cells, Cultured | Pancreatic Stellate Cells - pathology | Peptides - chemistry | Pyridones - pharmacokinetics | Matrix Metalloproteinase 2 - metabolism | Deoxycytidine - administration & dosage | Extracellular Matrix - drug effects | Pancreatic Neoplasms - pathology | Liposomes - chemistry | Animals | Mice, Nude | Liposomes - metabolism | Pyridones - therapeutic use | Extracellular Matrix - pathology | Deoxycytidine - analogs & derivatives | Pancreatic Stellate Cells - metabolism
Journal Article
Biomacromolecules, ISSN 1525-7797, 01/2019, Volume 20, Issue 1, pp. 422 - 434
Journal Article
ACS Biomaterials Science & Engineering, ISSN 2373-9878, 07/2018, Volume 4, Issue 7, pp. 2404 - 2411
Stimuli-responsive drug delivery systems with reduced side effects offer promising prospects for cancer therapy. In this study, we developed an... 
cancer therapy | target drug delivery | enzyme-stimulus | mesoporous nanoparticle | collagen I | hyaluronic acid | BIOCOMPATIBILITY | STEM-CELLS | MATERIALS SCIENCE, BIOMATERIALS | VIVO | MESOPOROUS SILICA NANOPARTICLES | POLYMERIC MICELLES | BREAST-CANCER | IN-VITRO | TUMOR-MICROENVIRONMENT | MMP-2 | HYALURONIDASE
Journal Article
Anticancer Research, ISSN 0250-7005, 12/2014, Volume 34, Issue 12, pp. 7431 - 7441
Journal Article
Biomaterials, ISSN 0142-9612, 11/2018, Volume 182, pp. 269 - 278
Despite the great success in clinical magnetic resonance imaging (MRI), Gd3+-based contrast agents still suffer from low proton relaxation efficiency, rapid... 
Transformation | MRI enhancement | Photodynamic therapy | MMP-2 | Chimeric peptide | DESIGN | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | RETENTION | DRUG-RELEASE | CANCER | NANOPARTICLES | PHARMACOKINETICS | TARGETED ACCUMULATION | GD-DOTA | IN-VIVO | MRI CONTRAST AGENTS | Peptides | Magnetic resonance imaging | Photochemotherapy | Contrast media | Cancer | Tumors
Journal Article
Laboratory Investigation, ISSN 0023-6837, 03/2011, Volume 91, Issue 3, pp. 439 - 451
Journal Article