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The lancet oncology, ISSN 1470-2045, 2019, Volume 20, Issue 4, pp. 556 - 569
In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here,... 
EXPLORATORY ANALYSES | MANAGEMENT | THERAPY | ONCOLOGY | PREFERENCES | PERSPECTIVES | QUALITY-OF-LIFE | METASTASIS-FREE SURVIVAL | CLINICAL-OUTCOMES | MMRM | Clinical trials | Medicine, Experimental | Medical research | Metastasis | Prostate cancer | Patient outcomes
Journal Article
Pharmaceutical statistics : the journal of the pharmaceutical industry, ISSN 1539-1604, 2019, Volume 18, Issue 6, pp. 636 - 644
Summary In confirmatory clinical trials, the prespecification of the primary analysis model is a universally accepted scientific principle to allow strict... 
model specification | mixed model | missing data | guideline | MMRM | Main Papers | Main Paper
Journal Article
Clinical Colorectal Cancer, ISSN 1533-0028, 12/2019, Volume 18, Issue 4, pp. 269 - 279.e5
We used European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) data from the LUME-Colon 1 study to illustrate... 
Nintedanib | HRQoL | Time to deterioration | MMRM | QoL | BEVACIZUMAB | OXALIPLATIN | METASTATIC COLORECTAL-CANCER | CORRECT | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | CLINICAL-TRIALS | REGORAFENIB | 1ST-LINE
Journal Article
Pharmaceutical statistics : the journal of the pharmaceutical industry, ISSN 1539-1612, 2008, Volume 7, Issue 2, pp. 93 - 106
This study compares two methods for handling missing data in longitudinal trials: one using the last‐observation‐carried‐forward (LOCF) method and one based on... 
drop‐out | LOCF | missing data | longitudinal trial | MMRM | Drop-out | Missing data | Longitudinal trial | drop-out | PHARMACOLOGY & PHARMACY | STATISTICS & PROBABILITY | Multivariate Analysis | Data Interpretation, Statistical | Bias | Computer Simulation | Humans | Clinical Trials as Topic - methods | Patient Dropouts | Longitudinal Studies
Journal Article
Molecular metabolism (Germany), ISSN 2212-8778, 2018, Volume 18, pp. 3 - 14
Journal Article
Pharmaceutical Statistics, ISSN 1539-1604, 10/2010, Volume 9, Issue 4, pp. 288 - 297
The Points to Consider Document on Missing Data was adopted by the Committee of Health and Medicinal Products (CHMP) in December 2001. In September 2007 the... 
multiple imputation | LOCF | missing data | MMRM | END-POINTS | PHARMACOLOGY & PHARMACY | STATISTICS & PROBABILITY | LONGITUDINAL CLINICAL-TRIALS | Research Design - standards | Clinical Trials as Topic - standards | Drug Industry - standards | Practice Guidelines as Topic - standards | Humans
Journal Article
Pain (Amsterdam), ISSN 0304-3959, 2014, Volume 155, Issue 9, pp. 1871 - 1877
This article reports deficiencies in reporting of missing data and methods to accommodate them, reviews methods to accommodate missing data that were... 
Missing data | Systematic review | ACTTION | EFFICACY | LOCF | CHRONIC PAIN TRIALS | PREVENTION | NEUROSCIENCES | CLINICAL NEUROLOGY | ISSUES | ANESTHESIOLOGY | VALUES | MMRM | Analgesics - therapeutic use | Clinical Trials as Topic | Statistics as Topic | Publishing | Pain - drug therapy | Humans | Analgesics | Clinical trials
Journal Article
Alzheimer's & Dementia: Translational Research & Clinical Interventions, ISSN 2352-8737, 2018, Volume 4, Issue 1, pp. 46 - 53
In clinical trials of Alzheimer's disease, a mixed-model repeated measure approach often serves as the primary analysis when evaluating disease progression; a... 
Clinical trials efficiency | Mixed-model repeated measure (MMRM) | Quantitative review | Mixed-effects models | Mixed‐model repeated measure (MMRM) | Mixed‐effects models
Journal Article
Journal of Biopharmaceutical Statistics, ISSN 1054-3406, 11/2018, Volume 28, Issue 6, pp. 1055 - 1077
Mixed Effects Models for Repeated Measures (MMRM) is often used in clinical trials with longitudinal data. However, there has not been an in-depth examination... 
clinical trials | interim analysis | group sequential testing | Alpha control | MMRM | CLINICAL-TRIALS | PHARMACOLOGY & PHARMACY | STATISTICS & PROBABILITY
Journal Article