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mms (120) 120
animals (65) 65
genetics & heredity (65) 65
toxicology (56) 56
dna damage (53) 53
methyl methanesulfonate (46) 46
methyl methanesulfonate - pharmacology (44) 44
humans (43) 43
dna repair (42) 42
biochemistry & molecular biology (38) 38
mutation (34) 34
methyl methanesulfonate - toxicity (32) 32
male (28) 28
mice (28) 28
biotechnology & applied microbiology (27) 27
cell biology (26) 26
dna (22) 22
saccharomyces cerevisiae - genetics (22) 22
apoptosis (21) 21
ems (21) 21
saccharomyces-cerevisiae (21) 21
dna damage - drug effects (20) 20
dose-response relationship, drug (20) 20
mutagens - toxicity (20) 20
female (19) 19
rats (18) 18
dna-damage (17) 17
repair (17) 17
ultraviolet rays (17) 17
homologous recombination (16) 16
molecular sequence data (16) 16
amino acid sequence (15) 15
ethyl methanesulfonate (15) 15
genotoxicity (15) 15
proteins (15) 15
recombination, genetic (15) 15
cells (14) 14
comet assay (13) 13
induction (13) 13
saccharomyces cerevisiae - drug effects (13) 13
cell line (12) 12
dna-repair (12) 12
escherichia-coli (12) 12
genes (12) 12
mutagens - pharmacology (12) 12
yeast (12) 12
analysis (11) 11
biophysics (11) 11
bone-marrow (11) 11
damage (11) 11
base excision-repair (10) 10
dna repair - drug effects (10) 10
dna repair - genetics (10) 10
expression (10) 10
in-vivo (10) 10
mammalian-cells (10) 10
mms, methyl methanesulfonate (10) 10
time factors (10) 10
alkylating agents - pharmacology (9) 9
base sequence (9) 9
cancer (9) 9
cell cycle (9) 9
cells, cultured (9) 9
dna-binding proteins - genetics (9) 9
dna-binding proteins - metabolism (9) 9
fungi (9) 9
genetics (9) 9
mnng (9) 9
rats, sprague-dawley (9) 9
saccharomyces cerevisiae - metabolism (9) 9
sequence homology, amino acid (9) 9
transcription factors - genetics (9) 9
antineoplastic agents - pharmacology (8) 8
environmental sciences (8) 8
gene (8) 8
in-vitro (8) 8
liver - drug effects (8) 8
mms sensitivity (8) 8
mutagenesis (8) 8
phenotype (8) 8
phosphorylation (8) 8
protein (8) 8
transcription factors - metabolism (8) 8
alkylating agents (7) 7
cell cycle proteins - metabolism (7) 7
deoxyribonucleic acid--dna (7) 7
double-strand breaks (7) 7
fungal proteins - genetics (7) 7
life sciences (7) 7
mms-sensitive mutants (7) 7
mutagens (7) 7
research (7) 7
s-phase (7) 7
saccharomyces cerevisiae proteins (7) 7
saccharomyces cerevisiae proteins - metabolism (7) 7
schizosaccharomyces-pombe (7) 7
transfection (7) 7
apoptosis - drug effects (6) 6
assay (6) 6
base excision repair (6) 6
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Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2007, Volume 360, Issue 2, pp. 483 - 489
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Journal Article
Mutation research. Genetic toxicology and environmental mutagenesis, ISSN 1383-5718, 2010, Volume 699, Issue 1, pp. 55 - 57
.... Methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) are also direct-acting but more stable compounds and form a different proportion of the various methyl and ethyl DNA adducts... 
MMS | Embryo | EMS | Mutation | MNU | ENU | INDUCED-TUMORS | NERVOUS-SYSTEM | DOSE-RESPONSE | TRANSPLACENTAL INDUCTION | MOUSE | RATS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALKYLATING-AGENTS | GENETICS & HEREDITY | MUTATION FREQUENCIES | TOXICOLOGY | MALIGNANT TUMOURS | TRANSGENIC MICE | Index Medicus
Journal Article
Journal of plant physiology, ISSN 0176-1617, 2019, Volume 233, pp. 20 - 30
Journal Article
FEBS letters, ISSN 0014-5793, 02/2012, Volume 586, Issue 4, pp. 303 - 309
► SM22α is induced in A549 non-small cell lung carcinoma cells by hypoxia. ► SM22α overexpression increased chemo- and radiation-resistance of A549 NSCLC... 
Chemo-resistance | Hypoxia | IGF1Rβ | SM22 | PI3K/Akt | IgG | silencing RNA | non-small cell lung carcinoma | EGFR | type 1 insulin-like growth factor receptor | reverse transcription-polymerase chain reaction | PI3K | methyl methanesulfonate | RT-PCR | senescence-associated β-galactosidase | immunoglobulin G | HIF | NSCLC | epidermal growth factor receptor | hypoxia-inducible factor | siRNA | SA-β-Gal | MMS | IGFIR | metallomatrix protease-9 | MMP-9 | phsophoinositotide-3-kinase | APOPTOSIS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IGF1R beta | TRANSGELIN | RECEPTOR | CELL BIOLOGY | LUNG-CANCER | SMOOTH-MUSCLE | GAMMA-RADIATION | BIOPHYSICS | GROWTH | SENESCENCE | EXPRESSION | Carcinoma, Non-Small-Cell Lung - radiotherapy | Gamma Rays | Lung Neoplasms - drug therapy | Receptor, IGF Type 1 - metabolism | Up-Regulation | Cell Hypoxia - physiology | Cell Hypoxia - radiation effects | Humans | Lung Neoplasms - metabolism | Radiation Tolerance | Lung Neoplasms - radiotherapy | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Muscle Proteins - metabolism | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Microfilament Proteins - genetics | Cell Hypoxia - drug effects | Carcinoma, Non-Small-Cell Lung - metabolism | Muscle Proteins - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Carcinoma, Non-Small-Cell Lung - drug therapy | Cell Hypoxia - genetics
Journal Article
DNA repair, ISSN 1568-7864, 12/2014, Volume 24, pp. 122 - 130
Unresolved replication intermediates can block the progression of replication forks and become converted into DNA lesions, hence exacerbating genomic... 
ATM | ATMIN | Replication stress |