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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 491 - 501
MSK 1 (mitogen- and stress-activated kinase 1) is a dual kinase domain protein that acts downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2)... 
Precursor ion scanning MS | cAMP-response-element-binding protein (CREB) | p90 ribosomal S6 kinase (RSK) | p38 | Extracellular-signal-regulated kinase (ERK) | Mitogen-activated protein kinase (MAPK) | precursor ion scanning MS | ACTIVATED PROTEIN-KINASE | STRESS-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | BINDING PROTEIN | DOCKING SITE | extracellular-signal-regulated kinase (ERK) | TUMOR-NECROSIS-FACTOR | LYSOPHOSPHATIDIC ACID | EMBRYONIC STEM-CELLS | HYDROPHOBIC MOTIF PHOSPHORYLATION | MAPKAP KINASE-2 | RIBOSOMAL S6 KINASE | Amino Acid Sequence | Cell Line | Phosphorylation | Humans | Molecular Sequence Data | Phosphoserine - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Sequence Alignment | Mutagenesis | Mass Spectrometry | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Conserved Sequence | Protein Binding | Enzyme Activation | Phosphoserine - chemistry | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | 2, MAPK | RSK, p90 ribosomal S6 kinase | MSK, mitogen- and stress-activated kinase | AGC-type kinases, protein kinase A | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase C-family kinases | LC, liquid chromatography | ERK kinase 1 | MNK, MAPK-integrating kinase | PKI, protein kinase A inhibitor | protein kinase G | CREB, cAMP-response-element-binding | GST, glutathione S-transferase | MS, tandem MS | ATF, activating transcription factor | MAPKAPK2 | MEK1 | MRM, multiple reaction monitoring | 3, MAPK-activated protein kinase-2 | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2005, Volume 389, Issue 3, pp. 775 - 783
A substrate for PKB alpha (protein kinase B alpha) was detected in liver extracts, and was purified and identified as CRHSP24 (calcium-regulated heat-stable... 
Protein kinase B (PKB) | p90 ribosomal S6 kinase (RSK) | Calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | Kinase substrate tracking and elucidation (KESTREL) | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM | P70 S6 KINASE | RNA-BINDING PROTEIN | PIPPIN | calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | IN-VIVO | protein kinase B (PKB) | COLD-SHOCK DOMAIN | MAPKAP KINASE-1 | kinase substrate tracking and elucidation (KESTREL) | BRAIN | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Liver - enzymology | Humans | Molecular Sequence Data | Rats | Phosphoproteins - metabolism | Rats, Sprague-Dawley | Sequence Homology, Nucleic Acid | DNA-Binding Proteins - metabolism | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Base Sequence | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | EST, expressed sequence tag | HEK-293, human embryonic kidney | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | FCS, foetal calf serum | MNK, MAPK-integrating kinase | IGF-1, insulin-like growth factor-1 | calcium-regulated heat-stable protein of 24 kDa (CRHSP24) | STYX, serine | CSD, cold-shock domain | DYRK, dual-specificity tyrosine-phosphorylated and -regulated protein kinase | GST, glutathione S-transferase | PP, protein phosphatase | KESTREL, kinasesubstrate tracking and elucidation | PH, pleckstrin homology | S6K, p70 ribosomal protein S6 kinase | threonine | CRHSP24, calcium-regulated heat-stable protein of 24 kDa | MKK1, MAPK kinase 1 | tyrosine-interacting protein | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Oncogene, ISSN 0950-9232, 01/2013, Volume 32, Issue 2, pp. 190 - 197
When mTOR inhibitor rapalogs prevent cap-dependent translation of cell-cycle proteins like c-myc, continuing tumor cell growth depends on cap-independent... 
mTOR inhibitors | IRES activity | multiple myeloma | c-myc | MNK kinases | rapamycin | MAMMALIAN TARGET | ENHANCED SENSITIVITY | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | INITIATION-FACTOR 4E | PROTEIN-SYNTHESIS | SITE FUNCTION | CELL BIOLOGY | AKT ACTIVITY | INTERNAL RIBOSOME ENTRY | ONCOLOGY | GENETICS & HEREDITY | N-TERMINI | Up-Regulation | Phosphorylation | Protein Biosynthesis | Nitriles - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - metabolism | Genes, myc | RNA, Messenger - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Butadienes - pharmacology | Aniline Compounds - pharmacology | Purines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Imidazoles - pharmacology | Multiple Myeloma - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Sirolimus - pharmacology | Animals | 5' Untranslated Regions | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Pyridines - pharmacology | RNA, Small Interfering | Multiple Myeloma - genetics | Care and treatment | Multiple myeloma | Ribosomes | Rapamycin | Dosage and administration | Research | Drug therapy | Phosphotransferases | Health aspects | Cancer | Proteins | Oncology | Kinases | Cell cycle | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2009, Volume 423, Issue 2, pp. 279 - 290
The human family of MAPK (mitogen-activated protein kinase) signal-integrating kinases (Mnks) comprises four related proteins derived from two genes by... 
Mitogen-activated protein kinase signal-integrating kinase (Mnk) | p38 mitogen-activatedprotein kinase (p38 MAPK), protein kinase | Extracellular-signal-regulated kinase (ERK) | Eukaryotic initiation factor 4E (eIF4E) | mitogen-activated protein kinase signal-integrating kinase (Mnk) | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INITIATION-FACTOR 4E | IDENTIFICATION | protein kinase | FEATURES | BETA | extracellular-signal-regulated kinase (ERK) | p38 mitogen-activated protein kinase (p38 MAPK) | MK2 | N-TERMINI | STRESS | eukaryotic initiation factor 4E (eIF4E) | EIF4E | Phosphorylation | Threonine - chemistry | Humans | Threonine - physiology | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Isoenzymes - chemistry | Structure-Activity Relationship | Extracellular Signal-Regulated MAP Kinases - metabolism | Threonine - metabolism | Phenylalanine - physiology | Isoenzymes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Isoenzymes - physiology | Amino Acid Sequence | Phenylalanine - metabolism | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Catalytic Domain - physiology | Sequence Homology, Amino Acid | Intracellular Signaling Peptides and Proteins - chemistry | Models, Biological | Protein Conformation | Protein-Serine-Threonine Kinases - chemistry | Intracellular Signaling Peptides and Proteins - physiology | Enzyme Activation - physiology | Protein Structure, Tertiary - physiology | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2005, Volume 385, Issue 3, pp. 695 - 702
In Drosophila cells, phosphorylation of eIF4E (eukaryotic initiation factor 4E) is required for growth and development. In Drosophila melanogaster, LK6 is the... 
Initiation factor | Protein kinase | Drosophila melanogaster | Extracellular-signal-regulated kinase (ERK) | LK6 | Translation factor | C-TERMINI | ACTIVATION | MNK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INITIATION-FACTOR 4E | TRANSLATION INITIATION | MAP KINASES | IDENTIFICATION | protein kinase | extracellular-signal-regulated kinase (ERK) | translation factor | N-TERMINI | RIBOSOMAL S6 KINASE | EIF4E | initiation factor | Mitogen-Activated Protein Kinase Kinases - genetics | Phosphorylation | Tetradecanoylphorbol Acetate - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Molecular Sequence Data | Eukaryotic Initiation Factor-4G - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Drosophila melanogaster - genetics | Cell Nucleus - enzymology | MAP Kinase Signaling System | Drosophila melanogaster - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Eukaryotic Initiation Factor-4E - genetics | Amino Acid Sequence | Cell Line | Cytoplasm - enzymology | Drosophila Proteins | Drosophila melanogaster - cytology | Enzyme Activation - drug effects | Phosphoserine - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | Animals | Drosophila melanogaster - enzymology | Protein Binding | Mice | Index Medicus | Mnk, MAPK signal-integrating kinase | eIF, eukaryotic initiation factor | GFP, green fluorescent protein | for brevity, the single-letter system for amino acids has been used, S209, for example means Ser209 | RNAi, RNA interference | WT, wild-type | HEK-293 cells, human embryonic kidney 293 cells | NES, nuclear export signal | CD, catalytic domain | dsRNAi, double-stranded RNAi | IEF, isoelectric focusing | ERK, extracellular-signal-regulated kinase | LMB, leptomycin B | MAPK, mitogen-activated protein kinase
Journal Article
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