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mnk (28) 28
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Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2013, Volume 450, Issue 2, pp. 351 - 363
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors,... 
Endothelin | α1-adrenergic receptor | P90 ribosomal S6 kinase (p90 RSK) | Transcriptomics | Cardiomyocyte | Mitogen-activated protein kinase (MAPK) | SNK, Student–Newman–Keuls | Lif, leukaemia inhibitory factor | Olr1, oxidized low-density lipoprotein (lectin-like) receptor 1 | Dusp, dual-specificity phosphatase | MNK, MAPK-interacting protein kinase | CREB, cAMP-response-element-binding protein | PKB, protein kinase B | ERK1 | RSK, ribosomal S6 kinase | transcriptomics | PE, phenylephrine | p90 ribosomal S6 kinase (p90 RSK) | AR, adrenergic receptor | Egr, early growth response | BH-MTC, Benjamini and Hochberg multiple testing correction | mitogen-activated protein kinase (MAPK) | ET-1, endothelin-1 | β, glycogen synthase kinase 3α | AMPKα, AMP-activated protein kinase α | Areg, amphiregulin | MKK, MAPK kinase | Rgs2, regulator of G-protein signalling 2, 24 kDa | 2, extracellular-signal-regulated kinase 1 | Atf3, activating transcription factor 3 | Klf, Krüppel-like factor | endothelin | GSK3α | Gapdh, glyceraldehyde 3-phosphate dehydrogenase | Plk2, polo-like kinase 2 | Nr4a, nuclear receptor subfamily 4, group A | Sik1, salt-inducible kinase 1 | cardiomyocyte | FDR, false discovery rate | Fosb, FBJ murine osteosarcoma viral oncogene homologue B | MSK, mitogen- and stress-activated protein kinase | IL11, interleukin 11 | NPE, nuclear protein-enriched | MAPK, mitogen-activated protein kinase | Ptgs2, prostaglandin-endoperoxide synthase 2, qPCR, quantitative PCR | Has, hyaluronan synthase
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2005, Volume 388, Issue 3, pp. 973 - 984
The hypertrophic G(q)-protein-coupled receptor agonist PE (phenylephrine) activates protein synthesis. We showed previously that activation of protein... 
mTOR | Mnk | Protein synthesis | Extracellular-signal-regulated kinase (ERK) | Hypertrophy | Myocyte | MESSENGER-RNA TRANSLATION | ADULT-RAT CARDIOMYOCYTES | hypertrophy | myocyte | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOINOSITIDE 3-KINASE/AKT PATHWAY | protein synthesis | INITIATION-FACTOR 4E | EPIDIDYMAL FAT-CELLS | P70 S6 KINASE | extracellular-signal-regulated kinase (ERK) | CARDIAC-HYPERTROPHY | DUAL-SPECIFICITY PHOSPHATASES | DISTINCT SIGNALING PATHWAYS | Cell Line | Insulin - pharmacology | Tumor Suppressor Proteins - metabolism | Aniline Compounds - pharmacology | Signal Transduction | Purines - pharmacology | Humans | Rats | Male | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Sirolimus - pharmacology | Gene Expression Regulation - drug effects | Myocytes, Cardiac - enzymology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Myocytes, Cardiac - drug effects | Phenylephrine - pharmacology | Myocytes, Cardiac - metabolism | Protein Biosynthesis - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | MEK, MAPK | p90RSK, 90 kDa ribosomal protein S6 kinase | PI3K, phosphoinositide 3-kinase | TSC, tuberous sclerosis complex | MKP3, MAPK phosphatase 3 | JNK, c-Jun N-terminal kinase | ERK kinase | ERK, extracellular-signal-regulated kinase | Mnk, MAPK-interacting kinase | PKB, protein kinase B | GSK, glycogen synthase kinase | PE, phenylephrine | mTOR, mammalian target of rapamycin | eIF, eukaryotic initiation factor | S6K, ribosomal protein S6 kinase | GFP, green fluorescent protein | HEK-293 cells, human embryonic kidney 293 cells | ARVC, adult rat ventricular cardiomyocytes | 4E-BP1, eIF4E-binding protein 1 | IEF, isoelectric focusing | MOI, multiplicity of infection | MAPK, mitogen-activated protein kinase
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 03/2019, Volume 23, Issue 3, pp. 187 - 199
Introduction: The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are switched on by the oncogenic MAPK (ERK) signalling pathway. They... 
eIF4E | mRNA translation | metastasis | transformation | MNKs | oncology | Cancer | MAMMALIAN TARGET | ANDROGEN RECEPTOR | FACTOR EIF-4E | ACTIVATED PROTEIN-KINASE | NUCLEAR EXPORT | INITIATION-FACTOR 4E | CELL-CYCLE PROGRESSION | MESSENGER-RNA | EIF4E PHOSPHORYLATION | CAP-DEPENDENT TRANSLATION | PHARMACOLOGY & PHARMACY
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 95, pp. 116 - 126
Journal Article
ChemMedChem, ISSN 1860-7179, 05/2014, Volume 9, Issue 5, pp. 962 - 972
Journal Article
Cellular Signalling, ISSN 0898-6568, 2006, Volume 18, Issue 9, pp. 1351 - 1359
Follicle-stimulating hormone (FSH) is necessary and sufficient to induce maturation of ovarian follicles to a mature, preovulatory phenotype in the intact... 
Protein kinase A | Mitogen-activated protein kinase | Follicle-stimulating hormone | Female reproduction | Hypoxia-induced factor 1 | Histone H3 | histone H3 | SIDE-CHAIN CLEAVAGE | follicle-stimulating hormone | OVARIAN-FOLLICLE | ELEMENT-BINDING PROTEIN | HISTONE H3 PHOSPHORYLATION | hypoxia-induced factor 1 | STEROIDOGENIC FACTOR-I | TRANSCRIPTION FACTOR FKHR | female reproduction | P38 MAP KINASE | LUTEINIZING-HORMONE | CELL BIOLOGY | mitogen-activated protein kinase | FOLLICLE-STIMULATING-HORMONE | protein kinase A | GROWTH-FACTOR-I | Cyclic AMP-Dependent Protein Kinases - metabolism | Follicle Stimulating Hormone - metabolism | Tumor Suppressor Proteins - metabolism | Granulosa Cells - physiology | Gene Expression Regulation | Protein Tyrosine Phosphatases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Animals | Forkhead Transcription Factors - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Female | Signal Transduction - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Histones - metabolism | Tyrosine | Chromatin | Phosphatases | Corticosteroids | Peptides | Tuberous sclerosis | Glycoproteins | DNA binding proteins | Hormones | Gene expression | Phosphatidylinositol | Luteinizing hormone | Mitogens | Vascular endothelial growth factor | Protein kinases | Growth factors | Protein binding | GIOT-1, gonadotropin-inducible ovarian transcription factor-1 | p70S6K, p70 ribosomal S6 kinase | TGFβ, transforming growth factor β | EGF, epidermal growth factor | CREB, cAMP response element binding protein | PDE, phosphodiesterase | R, PKA regulatory subunits | GPCR, G-protein-coupled receptor | MAP2D, microtubule-associated protein 2D | Sp1 | Epac, exchange proteins activated by cAMP | PI3K, phosphatidylinositol 3-kinase | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | AKAP, A kinase anchoring protein | Sp3, specific protein 1 | PKI, PKA inhibitor peptide | PKC, protein kinase C | SCC, P450 cholesterol side chain cleavage | VEGF, vascular endothelial growth factor | CBP, CREB binding protein | ERK, extracellular regulated kinase | MNK, MAPK-interacting kinase | Aromatase, P450 aromatase | ChIP, chromatin immunoprecipitation assay | HIF-1, hypoxia-induced factor-1 | Egr-1, early growth response protein-1 | LH, luteinizing hormone | MEK, mitogen- and extracellular-regulated kinase kinase | TSC, tuberous sclerosis complex tumor suppressor gene | SF-1, steroidogenic factor-1 | SGK, serum glucocorticoid kinase | RSK, p90 ribosomal S6 protein kinase | LRH-1, liver receptor homolog-1 | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | PTP, protein tyrosine phosphatase | FSH, follicle-stimulating hormone | MK, MAPK-activated protein kinases
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 05/2014, Volume 9, Issue 5, pp. 962 - 972
Phosphorylation of eIF4E by human mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is crucial for human tumourigenesis and development.... 
ACTIVATION | CHEMISTRY, MEDICINAL | apoptosis | CRYSTAL-STRUCTURES | GLIDE | KINASE INHIBITORS | CONFORMATION | CGP57380 | eIF4E phosphorylation | CDK INHIBITORS | ACCURATE DOCKING | GROWTH | PHARMACOLOGY & PHARMACY | SELECTIVITY | anticancer drug discovery | Mnk inhibitors
Journal Article
Oncotarget, 02/2015, Volume 6, Issue 5, p. 3195
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2013, Volume 4, Issue 8, pp. 736 - 741
Human mitogen-activated protein kinases (MAPK)-interacting kinases 1 and 2 (Mnk1/2) are promising anticancer targets. Mnks possess special insertions and a... 
insertion I1 | Mnk | DFD motif | molecular dynamics simulation | MOLECULAR-DYNAMICS | ACTIVATION | CHEMISTRY, MEDICINAL | DRUG-BINDING | PROTEIN | MAP KINASE | RECEPTOR | CANCER-THERAPY | REGULATORY MECHANISMS | INTERACTING KINASES | BINDING SITE
Journal Article
世界生物化学杂志:英文版(电子版), ISSN 1949-8454, 2014, Volume 5, Issue 3, pp. 321 - 333
The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA... 
kinase | production;Cytokine | signaling | resistance;Cytokine | kinases;mRNA | protein | translation;Mitogenactivated | phosphorylation;Drug | Mnk | signaling;eIF4E | Mnk kinases | mRNA translation | Cytokine production | Review | eIF4E phosphorylation | Drug resistance | Cytokine signaling | Mitogen-activated protein kinase signaling
Journal Article
Oncotarget, ISSN 1949-2553, 06/2019, Volume 10, Issue 40, p. 4053
We investigated the roles of eIF4E phosphorylation (Ser209) in tumour recurrence after curative nephrectomy for localized clear cell renal cell carcinoma... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 95, pp. 116 - 126
Phosphorylation of the eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is essential for... 
eIF4E | Inhibitor | Mnk | Thieno[2,3-d]pyrimidine derivatives | Structureeactivity relationship
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2007, Volume 406, Issue 3, pp. 445 - 455
Overexpression of P-glycoprotein, encoded by the MDR1 (multidrug resistance 1) gene, is often responsible for multidrug resistance in acute myeloid leukaemia.... 
mRNA translation | Drug resistance | Eukaryotic initiation factor-4E (EIF4E) | mRNA hairpin | Cytotoxic stress | NF-Y | CELLS | ACTIVATION | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | cytotoxic stress | TRANSLATIONAL CONTROL | PATHWAY | eukaryotic initiation factor-4E (eIF4E) | IN-VIVO | GENE-EXPRESSION | RESISTANCE | SECONDARY STRUCTURE | drug resistance | Blotting, Southern | Phosphorylation | Protein Biosynthesis | Luciferases - metabolism | Humans | RNA, Messenger - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Enzyme Inhibitors - pharmacology | Eukaryotic Initiation Factor-4E - metabolism | 5' Untranslated Regions - genetics | 5' Untranslated Regions - metabolism | RNA, Messenger - metabolism | Gene Expression Regulation - drug effects | Drug Resistance - genetics | Flow Cytometry | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | K562 Cells | Polymerase Chain Reaction | Transcription, Genetic | ATP Binding Cassette Transporter, Sub-Family B | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Eukaryotic Initiation Factor-4E - genetics | RNA, Messenger - drug effects | eIF, eukaryotic initiation factor | MDR1, multidrug resistance 1 | PI3K, phosphoinositide 3-kinase | 4E-BP, eIF4E-binding protein | UTR, untranslated region | siRNA, small interfering RNA | ERK, extracellular-signal-regulated kinase | Mnk, MAPK-interacting kinase | RT, reverse transcriptase | mTOR, mammalian target of rapamycin | Q-PCR, quantitative PCR | MAPK, mitogen-activated protein kinase
Journal Article