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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 36, Issue 11, pp. 2259 - 2267
OBJECTIVE—To examine select adipokines, including fatty acid–binding protein 4, retinol-binding protein 4, and high-molecular-weight (HMW) adiponectin in... 
adiponectin | cardiovascular disease | heart failure | adipokines | fatty acid-binding proteins | GENETIC-VARIANTS | NATRIURETIC PEPTIDE | ALL-CAUSE | HUMAN THP-1 MACROPHAGES | INSULIN-RESISTANCE | COLORECTAL-CANCER | BODY-MASS INDEX | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | CHRONIC KIDNEY-DISEASE | HEMATOLOGY | ADIPOSE-TISSUE | Multivariate Analysis | United States - epidemiology | Molecular Weight | Prognosis | Prospective Studies | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Cardiovascular Diseases - genetics | Cause of Death | Time Factors | Adiponectin - genetics | Fatty Acid-Binding Proteins - blood | Mendelian Randomization Analysis | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality | Adult | Cardiovascular Diseases - diagnosis | Retinol-Binding Proteins, Plasma - analysis | Genetic Predisposition to Disease | Risk Assessment | Risk Factors | Proportional Hazards Models | Linear Models | Biomarkers - blood | Chi-Square Distribution | Fatty Acid-Binding Proteins - genetics | Adiponectin - blood | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - mortality | Sex Factors | Aged | Polymorphism, Single Nucleotide | Retinol-Binding Proteins, Plasma - genetics | Index Medicus | mortality | high-molecular weight adiponectin | fatty acid-binding protein | retinol-binding protein 4 | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 52, pp. 18590 - 18595
There is great interest in developing selective protein kinase inhibitors by targeting allosteric sites, but these sites often involve protein-protein or... 
Proteins | Molecules | Phosphorylation | Prodrugs | Sulfonamides | Allosteric site | Competitive binding | Ligands | Chemicals | Crystal structure | Peptide mimicry | Allostery | Drug discovery | Protein-protein interaction | SITE | ACTIVATION | FLUORESCENCE POLARIZATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PIF-POCKET | CATALYTIC DOMAIN | MECHANISMS | IDENTIFICATION | DISCOVERY | drug discovery | PRODRUGS | peptide mimicry | protein-protein interaction | allostery | 3-Phosphoinositide-Dependent Protein Kinases - chemistry | Humans | Crystallography, X-Ray | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Allosteric Regulation - drug effects | Peptides - chemistry | Protein Structure, Secondary | 3-Phosphoinositide-Dependent Protein Kinases - genetics | Neoplasms - enzymology | Neoplasm Proteins - chemistry | 3-Phosphoinositide-Dependent Protein Kinases - antagonists & inhibitors | 3-Phosphoinositide-Dependent Protein Kinases - metabolism | Antineoplastic Agents - chemistry | Amino Acid Motifs | Neoplasms - drug therapy | Peptides - pharmacology | Allosteric Site | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Physiological aspects | Protein research | Research | Peptides | Protein kinases | Protein-protein interactions | Mutation | Kinases | Molecular weight | Index Medicus | protein–protein interaction | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, pp. e39679 - e39679
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processes in cells in response to mitogens and variations in... 
CELLS | TRANSCRIPTIONAL ACTIVATION | DNA-BINDING | PHOSPHOPROTEOMIC ANALYSIS | FACTOR-1 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | AUTOPHAGY | BINDING PROTEIN | THERMOTOLERANCE | Phosphotransferases - metabolism | Phosphorylation | Protein Biosynthesis | Transcription Factors - chemistry | TOR Serine-Threonine Kinases - metabolism | Humans | Stress, Physiological | Heat-Shock Proteins - biosynthesis | Molecular Sequence Data | Substrate Specificity | Promoter Regions, Genetic - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Peptides - metabolism | Transcription, Genetic | Amino Acid Sequence | Peptides - chemistry | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Gene Silencing | HSP70 Heat-Shock Proteins - genetics | Phosphoserine - metabolism | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Heat-Shock Response | HeLa Cells | RNA | Genes | Heat shock proteins | Protein biosynthesis | Amino acids | Genetic transcription | Protein kinases | Mitogens | Cell culture | Tissue culture | Proteins | Signal transduction | Life sciences | Sodium arsenite | Stress response | Chemical synthesis | Deoxyribonucleic acid--DNA | Stresses | Medical research | RNA-mediated interference | Rapamycin | Hsp70 protein | Gene expression | Heat | Ribonucleic acids | Sodium | Protein synthesis | Adapter proteins | Hyperthermia | TOR protein | Shock | Hsp90 protein | Serine | Gene regulation | Oncology | Activation | Kinases | Autophagy | Molecular weight | Heat shock factors | Reduction | Transcription activation | HSF1 protein | Alanine | Fever | Proteasome inhibitors | Stress | Protein kinase | Plasmids | Nutrient availability | Protein expression | Arsenite | Heat shock | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 438 - 442
The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that responds to diverse environmental signals and is deregulated... 
ENCEPHALOPATHY | COMPLEX | SZT2 | RAG GTPASES | GENE | SIGNALING PATHWAY | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | MUTATIONS | FOCAL EPILEPSIES | Lysosomes | Physiological aspects | Protein research | Research | Biological control systems | Protein-protein interactions | Proteins | Amino acids | Phosphorylation | Mutation | Glucose | Molecular weight | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2001, Volume 276, Issue 37, pp. 35176 - 35184
Assembly of the amyloid beta -protein (A beta) into neurotoxic oligomers and fibrils is a seminal event in Alzheimer's disease. Understanding the earliest... 
FIBRIL FORMATION | ENHANCED PRODUCTION | IN-VITRO | ATOMIC-FORCE MICROSCOPY | CONFORMATIONAL-CHANGES | TRANSTHYRETIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CULTURE | FIBRILLOGENESIS | PEPTIDE | Prealbumin - chemistry | Molecular Weight | Amyloid beta-Peptides - chemistry | Light | Hydrogen-Ion Concentration | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 45, pp. 39318 - 39327
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2019, Volume 10, Issue 1, pp. 2008 - 13
G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating neurotransmission. GIRK is opened by the direct binding of the G... 
XPLOR-NIH | KIR3 CHANNELS | ALPHA-SUBUNIT | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | METHYL-GROUPS | GIRK CHANNELS | PARAMAGNETIC RELAXATION ENHANCEMENT | MOLECULAR-WEIGHT PROTEINS | K+ CHANNELS | Recombinant Proteins - metabolism | GTP-Binding Protein gamma Subunits - metabolism | Recombinant Proteins - ultrastructure | GTP-Binding Protein alpha Subunits, Gi-Go - isolation & purification | Humans | Models, Molecular | Bioluminescence Resonance Energy Transfer Techniques | Recombinant Proteins - isolation & purification | GTP-Binding Protein gamma Subunits - ultrastructure | Ion Channel Gating - physiology | GTP-Binding Protein beta Subunits - ultrastructure | GTP-Binding Protein alpha Subunits, Gi-Go - ultrastructure | GTP-Binding Protein beta Subunits - isolation & purification | HEK293 Cells | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Nuclear Magnetic Resonance, Biomolecular | GTP-Binding Protein gamma Subunits - isolation & purification | GTP-Binding Protein beta Subunits - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - ultrastructure | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Proteins | Receptors | G protein-coupled receptors | Nuclear magnetic resonance--NMR | Potassium channels (inwardly-rectifying) | Potassium | Neurotransmission
Journal Article