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SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, p. 6151
Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs)... 
MONOAMINE-OXIDASE-B | PLASMA | RECEPTORS | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 04/2018, Volume 59, Issue 4, pp. 671 - 674
Clinical PET studies using F-18-THK5351 have demonstrated significant tracer retention in sites susceptible to tau burden in Alzheimer disease (AD). However,... 
imaging-pathology correlation | HUMAN BRAIN | ASTROCYTOSIS | MONOAMINE-OXIDASE-B | tau | Alzheimer's disease | AUTORADIOGRAPHY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
BIOCHEMISTRY, ISSN 0006-2960, 08/2010, Volume 49, Issue 30, pp. 6494 - 6503
Lysine-specific demethylase 1 (LSDI/KDMI) demethylates histone H3, in addition to tumor suppressor p53 and DNA methyltransferase I (Dnmt1), thus regulating... 
NMR SYSTEM | METHYLATION | METHYLTRANSFERASE | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | LSD1 | MONOAMINE-OXIDASE-B | CRYSTALLOGRAPHY | REEXPRESSION | SILENCED GENES
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2020, Volume 162, p. 107809
The metabotropic glutamate receptor 5 (mGluR5) ligands fenobam and AZD9272 have been reported to induce psychosis-like adverse events and to bind at unknown,... 
Autoradiography | Fenobam | PET imaging | Metabotropic glutamate receptor 5 | AZD9272 | Monoamine oxidase-B
Journal Article
Biochemistry, ISSN 0006-2960, 07/2018, Volume 57, Issue 26, pp. 3741 - 3751
Nicotine oxidoreductase (NicA2) is a bacterial flavoenzyme, which catalyzes the first step of nicotine catabolism by oxidizing S-nicotine into... 
OXIDATION | MONOAMINE-OXIDASE-B | DEGRADATION | EXPLORER | IDENTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Index Medicus
Journal Article
Chemical Reviews, ISSN 0009-2665, 2018, Volume 119, Issue 2, pp. 1221 - 1322
Neurodegenerative diseases pose a substantial socioeconomic burden on society. Unfortunately, the aging world population and lack of effective cures foreshadow... 
MULTITARGET-DIRECTED LIGANDS | ALPHA-SYNUCLEIN AGGREGATION | AMYLOID-BETA-PEPTIDE | MONOAMINE-OXIDASE-B | PAIRED HELICAL FILAMENTS | MANNICH BASE DERIVATIVES | METAL-CHELATING PROPERTIES | DRUG DESIGN STRATEGY | MOTOR-NEURON DISEASE | TRANSGENIC MOUSE MODEL | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3596 - 3600
The synthesis and biological activity of 4- -pentylphenoxypropyl derivatives are described in this manuscript. All compounds (except one) showed human... 
Monoamine oxidase B | Small molecule inhibitors | 4-tert-Pentylphenoxy derivatives | Histamine H3 receptor | Kinetic studies
Journal Article
ALZHEIMERS RESEARCH & THERAPY, ISSN 1758-9193, 03/2017, Volume 9
Background: F-18-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of F-18-THK5351... 
F-18-THK5351 tau tracer | Selegiline | ASTROCYTOSIS | ALZHEIMERS-DISEASE | MAO-B | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | CLINICAL NEUROLOGY | POSITRON-EMISSION-TOMOGRAPHY | Monoamine oxidase-B | AMYLOID-BETA | IN-VIVO | L-DEPRENYL | Alzheimer's disease | Positron emission tomography | PET | PROGRESSIVE SUPRANUCLEAR PALSY
Journal Article
Synthesis, ISSN 0039-7881, 02/2019, Volume 51, Issue 4, pp. 885 - 888
Abstract The asymmetric synthesis of (3 R ,5 S )-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3 H )-one, as the most potent selective inactivator of... 
paper | aziridines | asymmetric synthesis | ring opening | γ-aminomethyl-γ-lactone | gamma-aminomethyl--lactone | RING | MONOAMINE-OXIDASE-B | CHEMISTRY, ORGANIC
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 03/2017, Volume 9, Issue 1, pp. 1 - 9
Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351... 
Selegiline | Alzheimer's disease | Positron emission tomography | Monoamine oxidase-B | F-THK5351 tau tracer | Hypotheses | Medical imaging | Nuclear magnetic resonance--NMR | Brain research | Disease | Binding sites | 18F-THK5351 tau tracer | Alzheimer’s disease
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 886 - 896
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUTAMATE RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAO-B | CELL BIOLOGY | PUTRESCINE | CHANNEL | MONOAMINE-OXIDASE-B | SELEGILINE | CULTURED ASTROCYTES | L-DEPRENYL | MICE | DENTATE GYRUS | Memory - drug effects | RNA, Small Interfering - genetics | Alzheimer Disease - complications | Amyloid beta-Peptides - pharmacology | Humans | Ion Channels - genetics | Memory Disorders - metabolism | Male | Peptide Fragments - pharmacology | Monoamine Oxidase - genetics | GABA Antagonists - therapeutic use | Bestrophins | Eye Proteins - genetics | Putrescine - pharmacology | Disease Models, Animal | Astrocytes - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Dentate Gyrus - metabolism | Cerebellum - metabolism | Mice, Inbred C57BL | Alzheimer Disease - drug therapy | Mice, Transgenic | Hippocampus - cytology | Mice, Inbred ICR | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Maze Learning | Memory Disorders - drug therapy | Memory Disorders - etiology | Eye Proteins - metabolism | Ion Channels - metabolism | gamma-Aminobutyric Acid - biosynthesis | Alzheimer Disease - metabolism | Receptors, GABA - metabolism | Plaque, Amyloid - metabolism | Mice | Astrocytes - metabolism | Monoamine Oxidase - metabolism | Care and treatment | Monoamine oxidase | Analysis | Physiological aspects | GABA | Diagnosis | Alzheimer's disease | Risk factors | Models | Alzheimers disease | Memory | Rodents
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2013, Volume 62, pp. 132 - 144
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 08/2011, Volume 54, Issue 10, pp. 678 - 680
Journal Article
CHEMICAL SOCIETY REVIEWS, ISSN 0306-0012, 2016, Volume 45, Issue 17, pp. 4708 - 4726
The positron-emitting radionuclide carbon-11 (C-11, t(1/2) = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring,... 
ACID AMIDE HYDROLASE | FATTY-ACID | MONOAMINE-OXIDASE-B | KAPPA-OPIOID RECEPTOR | HIGH-AFFINITY STATE | HUMAN-BRAIN | PRELIMINARY SCINTIGRAPHIC EVALUATION | CHEMOTHERAPEUTIC AGENT BCNU | CAPTIVE SOLVENT METHOD | IN-VIVO EVALUATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article