X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (366) 366
Publication (71) 71
Newsletter (16) 16
Book Chapter (14) 14
Book Review (9) 9
Conference Proceeding (6) 6
Magazine Article (4) 4
Newspaper Article (3) 3
Streaming Video (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (267) 267
index medicus (255) 255
monoclonal antibodies (180) 180
animals (172) 172
immunology (107) 107
monoclonal-antibody (84) 84
immunotherapy (75) 75
t cells (75) 75
antibodies, monoclonal - therapeutic use (70) 70
pharmacology & pharmacy (70) 70
cancer (68) 68
monoclonal-antibody tgn1412 (63) 63
cytokines (60) 60
mice (57) 57
cytokine storm (54) 54
regulatory t-cells (54) 54
clinical trials (51) 51
trial (50) 50
research (46) 46
t-lymphocytes - immunology (46) 46
analysis (44) 44
health aspects (44) 44
antibodies, monoclonal - adverse effects (43) 43
cd28 antigens - immunology (43) 43
medicine, research & experimental (41) 41
oncology (41) 41
lymphocytes (40) 40
tgn1412 (39) 39
dendritic cells (38) 38
immune system (37) 37
antibodies, monoclonal - immunology (36) 36
inflammation (36) 36
review (36) 36
safety (36) 36
toxicology (36) 36
neoplasms - immunology (34) 34
antigens (33) 33
in-vitro (33) 33
in-vivo (33) 33
antibodies, monoclonal - pharmacology (32) 32
article (32) 32
expression (32) 32
monoclonal antibody (32) 32
proteins (32) 32
cd28 (31) 31
immunoglobulins (31) 31
autoimmunity (30) 30
medical research (30) 30
antibodies, monoclonal, humanized (29) 29
clinical trials as topic (29) 29
rheumatoid-arthritis (29) 29
therapy (29) 29
autoimmune diseases (28) 28
biological products (28) 28
immunotherapy - methods (28) 28
transplantation (28) 28
antibodies (27) 27
care and treatment (27) 27
double-blind (27) 27
phase-i (27) 27
t-lymphocytes, regulatory - immunology (27) 27
activation (26) 26
biotechnology & applied microbiology (26) 26
lymphocytes t (26) 26
male (26) 26
neoplasms - therapy (26) 26
drug therapy (25) 25
drugs (25) 25
monoclonal-antibodies (25) 25
pharmacokinetics (25) 25
t-cells (25) 25
cytokines - immunology (24) 24
female (23) 23
t cell receptors (23) 23
toxicity (23) 23
abridged index medicus (22) 22
antibodies, monoclonal - administration & dosage (22) 22
cells (22) 22
immunosuppression (22) 22
pharmaceutical industry (22) 22
cytokines - metabolism (21) 21
immunomodulation (21) 21
binding (20) 20
cd28 antigen (20) 20
cells, cultured (20) 20
drug evaluation, preclinical (20) 20
flow cytometry (20) 20
medicine (20) 20
risk assessment (20) 20
biochemistry & molecular biology (19) 19
costimulation (19) 19
disease models, animal (19) 19
immunity (19) 19
immunogenicity (19) 19
pharmacology (19) 19
cell biology (18) 18
drug development (18) 18
immune response (18) 18
neoplasms - drug therapy (18) 18
pharmacodynamics (18) 18
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
European Journal of Immunology, ISSN 0014-2980, 04/2014, Volume 44, Issue 4, pp. 1225 - 1236
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 09/2015, Volume 424, pp. 43 - 52
The therapeutic monoclonal antibody (mAb) TGN1412 (anti-CD28 superagonist) caused near-fatal cytokine release syndrome (CRS) in all six volunteers during a... 
Whole blood | Group size | TGN1412 | Cytokine release assay | PBMC | Therapeutic mAb | REVEALS WORRYING DIFFERENCES | BIOCHEMICAL RESEARCH METHODS | MONOCLONAL-ANTIBODY TGN1412 | IMMUNOLOGY | VITRO ASSAYS | FC-GAMMA-RIIB | T-CELL RESPONSES | MULTIPLE-SCLEROSIS | RITUXIMAB | CD28 | CHRONIC LYMPHOCYTIC-LEUKEMIA | SYNDROME IN-VIVO | Antibodies, Monoclonal, Humanized - adverse effects | Leukocytes, Mononuclear - metabolism | Glycophorin - metabolism | Antibodies, Monoclonal, Humanized - therapeutic use | Leukocytes, Mononuclear - drug effects | Cytokines - metabolism | Humans | Immunoglobulin G - therapeutic use | Antineoplastic Agents - therapeutic use | Alemtuzumab | Daclizumab | Fluoroimmunoassay - methods | Antibodies, Monoclonal - administration & dosage | Antineoplastic Agents - adverse effects | Antibodies, Monoclonal, Humanized - pharmacology | Erythrocytes - metabolism | Immunoglobulin G - pharmacology | Cytokines - blood | Cytokines | Monoclonal antibodies | Health aspects | GYPA, glycophorin A | mAb, monoclonal antibody | WBC, white blood cells | IFNγ, interferon gamma | TNFα, tumor necrosis factor alpha | HDC, high density culture | SP, Solid Phase | RBCs, Red Blood Cells | PBMCs, peripheral blood mononuclear cells | CRS, cytokine release syndrome | IL-2, interleukin-2 | AQ, Aqueous Phase | WB, whole blood | PBS, phosphate buffered saline | IL-8, interleukin-8 | IL-13, interleukin-13 | CRA, cytokine release assay | IL-2R, interleukin-2 receptor | IL-17, interleukin-17 | TCR, T cell receptor
Journal Article
European Journal of Immunology, ISSN 0014-2980, 07/2019, Volume 49, Issue 7, pp. 1117 - 1126
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 05/2012, Volume 12, Issue 5, pp. 317 - 318
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2018, Volume 502, Issue 1, pp. 91 - 97
To detect potential risk of severe cytokine release syndrome, in vitro assay formats with human cells have been developed. The two major testing platforms are... 
Antibody preparation | Screening | In vitro | Cytokine release syndrome | TGN1412 | In vitro | RELEASE SYNDROME | CELLS | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY TGN1412 | TRIAL | STORM | BIOPHYSICS | ENGAGEMENT | Viral antibodies | Antibodies | Cytokines | T cells | Cells
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2011, Volume 118, Issue 26, pp. 6772 - 6782
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2019, Volume 372, pp. 57 - 69
Cytokine release syndrome (CRS) is a serious and potentially life-threatening complication typically associated with biological drug products. Pre-clinical... 
CD34-humanized mouse | Cytokine release syndrome | BLT-humanized mouse | SYSTEM | RESPONSES | PHARMACOLOGY & PHARMACY | MONOCLONAL-ANTIBODY | MICE | TOXICOLOGY | CYTOKINE RELEASE | CD28 SUPERAGONIST | BLOOD | Animal experimentation | Primates | T cells | Adalimumab | Analysis | Liver
Journal Article