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Cell, ISSN 0092-8674, 2007, Volume 130, Issue 5, pp. 906 - 917
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its... 
PROTEINS | MOLIMMUNO | BACTERIAL LIPOPOLYSACCHARIDE | MD-2 BINDS | CELL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | PROTEIN COMPLEXES | LEUCINE-RICH REPEAT | LIPID IVA | CONFERS LIPOPOLYSACCHARIDE RESPONSIVENESS | TLR4 | MONOMERIC ENDOTOXIN | CELL BIOLOGY | Disaccharides - metabolism | Lymphocyte Antigen 96 - metabolism | Humans | Immunoglobulin Variable Region - chemistry | Lipopolysaccharides - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Hagfishes | Lipopolysaccharides - antagonists & inhibitors | Disaccharides - chemistry | Lymphocyte Antigen 96 - genetics | Disaccharides - pharmacology | Sugar Phosphates - pharmacology | Lymphocyte Antigen 96 - chemistry | Cloning, Molecular | Protein Engineering | Molecular Structure | Toll-Like Receptor 4 - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Fish Proteins - chemistry | Sugar Phosphates - chemistry | Models, Molecular | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - chemistry | Recombinant Fusion Proteins - chemistry | Toll-Like Receptor 4 - metabolism | Animals | Sugar Phosphates - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Lipopolysaccharides - chemistry | Mice | Structural Homology, Protein | Mutation | Structure | Crystals | Index Medicus
Journal Article
INNATE IMMUNITY, ISSN 1753-4259, 10/2013, Volume 19, Issue 5, pp. 545 - 560
A purified complex of metabolically labeled [H-3]lipooligosaccharide (LOS) and recombinant human myeloid differentiation factor 2 (MD-2), [H-3]LOSMD-2, has... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIPOPOLYSACCHARIDE RESPONSIVENESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | CELL-SURFACE | MICROBIOLOGY | TLR4-MD-2 COMPLEX | LIPID-IVA | IMMUNOLOGY | Endotoxin | LPS | TOLL-LIKE RECEPTOR-4 | MD-2 | PROTEIN COMPLEXES | TLR4 | HUMAN MD-2 | MONOMERIC ENDOTOXIN | TOLL-LIKE-RECEPTOR-4 ECTODOMAIN
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 06/2008, Volume 38, Issue 6, pp. 647 - 654
Endotoxins represent one of the most potent classes of microbial immunoactive components that can cause pulmonary inflammation. The aim of this study was to... 
Pulmonary inflammation | Lipooligosaccharide | Endotoxin | Inhalation | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | pulmonary inflammation | BINDING-PROTEIN | INDUCED INFLAMMATION | CELL BIOLOGY | inhalation | GRAM-NEGATIVE BACTERIA | CELL ACTIVATION | RESPIRATORY SYSTEM | PSEUDOMONAS-AERUGINOSA | PROTEIN COMPLEXES | CYSTIC-FIBROSIS AIRWAY | lipooligosaccharide | MONOMERIC ENDOTOXIN | LUNG INFLAMMATION | endotoxin | Chemokine CCL3 - immunology | Humans | Lipopolysaccharides - administration & dosage | Neisseria meningitidis, Serogroup B - immunology | Bronchoalveolar Lavage Fluid - immunology | Male | Lung - cytology | Lipopolysaccharides - immunology | Neisseria meningitidis, Serogroup B - chemistry | Dose-Response Relationship, Drug | Lymphocyte Antigen 96 - genetics | Endotoxins - chemistry | Tumor Necrosis Factor-alpha - immunology | Bronchoalveolar Lavage Fluid - cytology | Neisseria meningitidis, Serogroup B - pathogenicity | Mice, Inbred C57BL | Neutrophils - immunology | Administration, Inhalation | Interleukin-1beta - immunology | Mice, Knockout | Animals | Endotoxins - immunology | Lung - drug effects | Lipopolysaccharides - pharmacology | Endotoxins - administration & dosage | Lipopolysaccharides - chemistry | Mice | Mice, Inbred BALB C | Granulocyte Colony-Stimulating Factor - immunology | Endotoxins - pharmacology | Lung - immunology | Lymphocyte Antigen 96 - immunology | Index Medicus
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2016, Volume 196, Issue 5, pp. 2309 - 2318
Myeloid differentiation factor 2 (MD-2) is an extracellular protein, associated with the ectodomain of TLR4, that plays a critical role in the recognition of... 
DUST-MITE ALLERGEN | TOLL-LIKE RECEPTOR-4 | CELL ACTIVATION | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | BINDING-PROTEIN | PROTEIN COMPLEXES | LIPID IVA | TLR4-MD-2 COMPLEX | IMMUNOLOGY | MONOMERIC ENDOTOXIN
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 4, pp. 2477 - 2484
The bactericidal/permeability-increasing protein (BPI) is thought to play an important role in killing and clearance of Gram negative bacteria and the... 
AMINO-TERMINAL FRAGMENT | POLYMORPHONUCLEAR LEUKOCYTES | PERITONEAL INFLAMMATORY EXUDATE | COMPLEMENT ACTIVATION | LIPOPOLYSACCHARIDE-BINDING-PROTEIN | NEISSERIA-MENINGITIDIS | ESCHERICHIA-COLI | ANTIGEN PRESENTATION | IMMUNOLOGY | MONOMERIC ENDOTOXIN | WHOLE BACTERIA | Antimicrobial Cationic Peptides - immunology | Antigens, CD - immunology | Membrane Glycoproteins - metabolism | Dendritic Cells - immunology | Humans | Antigens, Bacterial - immunology | Neisseria meningitidis, Serogroup B - immunology | Blood Proteins - immunology | Antimicrobial Cationic Peptides - metabolism | Blood Proteins - metabolism | Antigens, CD - metabolism | Signal Transduction - immunology | Biological Transport, Active - immunology | Histocompatibility Antigens Class II - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Membrane Glycoproteins - immunology | Carrier Proteins - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Chemokines - immunology | Endotoxins - metabolism | Acute-Phase Proteins - metabolism | Cells, Cultured | Membrane Proteins - immunology | Antigen Presentation - immunology | Protein Binding - immunology | Immunity, Innate - immunology | Macrophages - metabolism | Carrier Proteins - metabolism | Endotoxins - immunology | Cell Membrane - immunology | Chemokines - metabolism | Antigens, Bacterial - metabolism | Acute-Phase Proteins - immunology | Index Medicus | Abridged Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, 05/2012, Volume 287, Issue 20, pp. 16346 - 16355
Host response to invasion by many Gram-negative bacteria depends upon activation of Toll-like receptor 4 (TLR4) by endotoxin presented as a monomer bound to... 
CELL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEISSERIA-MENINGITIDIS | PROTEIN COMPLEXES | TLR4-MD-2 COMPLEX | LIPID IVA | RECEPTOR 4 | TOLL-LIKE-RECEPTOR-4 ECTODOMAIN | MONOMERIC ENDOTOXIN | LIPOPOLYSACCHARIDE RECOGNITION | INNATE IMMUNITY
Journal Article
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, ISSN 1003-0603, 02/2004, Volume 16, Issue 2, p. 73
Journal Article
Journal Article