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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 10/2015, Volume 192, Issue 7, pp. 859 - 872
Rationale: Mutations in bone morphogenetic protein receptor type II (BMPR-II) underlie most cases of heritable pulmonary arterial hypertension (PAH). However,... 
cytokine | TGF-BETA | PULMONARY ARTERIAL-HYPERTENSION | pulmonary hypertension | HETEROZYGOUS MICE | SYSTEMIC-SCLEROSIS | INTERLEUKIN-6 | HYPOXIA | bone morphogenetic protein receptor type II | SMOOTH-MUSCLE | inflammation | RESPIRATORY SYSTEM | MOUSE MODEL | lipopolysaccharide | EXTRACELLULAR-SUPEROXIDE DISMUTASE | EXPRESSION | CRITICAL CARE MEDICINE
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2016, Volume 194, Issue 6, pp. 719 - 728
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 44, pp. 36990 - 36998
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0132221 - e0132221
Abnormal alteration of bone morphogenetic protein (BMP) signaling is implicated in many types of diseases including cancer and heterotopic ossifications.... 
FREE-ENERGY CALCULATIONS | POLYPOSIS SYNDROME | POTENT | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | DYNAMICS | KINASE INHIBITOR | CHARMM | BINDING FREE-ENERGIES | DISCOVERY | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | Activin Receptors, Type I - antagonists & inhibitors | Receptor, Transforming Growth Factor-beta Type I | Receptors, Transforming Growth Factor beta - chemistry | Humans | Substrate Specificity | Crystallography, X-Ray | Pyrimidines - chemistry | Quinolines - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Adenosine Triphosphate - metabolism | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Binding Sites - drug effects | Pyrazoles - pharmacology | Bone Morphogenetic Protein Receptors, Type I - antagonists & inhibitors | Protein Structure, Tertiary | Quinolines - chemistry | Pyrimidines - pharmacology | Activin Receptors, Type I - genetics | Molecular Dynamics Simulation | Amino Acid Motifs | Point Mutation | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Bone Morphogenetic Protein Receptors, Type I - chemistry | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Ligands | Protein Conformation | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Activin Receptors, Type I - chemistry | Amino Acid Substitution | Vascular endothelial growth factor | Phosphotransferases | Growth factors | Analysis | Health sciences | Molecular dynamics | Selectivity | Kinases | Proteins | Receptors | Energy | Bone morphogenetic proteins | Docking | Protein-tyrosine kinase | Pharmaceutical sciences | Quantitative analysis | Tyrosine | Computer simulation | Test procedures | Pharmacology | Free energy | Diseases | Signaling | Inhibitors | Computation | Pharmacy | Computer applications | Determinants | Bone | Aberration | Binding sites | Cancer | Index Medicus
Journal Article
Journal Article
European Respiratory Journal, ISSN 0903-1936, 09/2017, Volume 50, Issue 3, pp. 1701370 - 1701370
Since the demonstration nearly 20 years ago that mutations of bone morphogenic protein receptor 2 (BMPR2) are associated with heritable pulmonary arterial... 
GENE | RESPIRATORY SYSTEM | MUTATIONS | Hypertension | Animal models | Bone morphogenetic protein receptor type II | Tacrolimus | Lung | Mutation | Gene expression | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2001, Volume 28, Issue 2, pp. 184 - 187
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2018, Volume 495, Issue 1, pp. 493 - 498
Illumination of the molecular mechanisms regulating odontoblastic differentiation of dental papilla cells is of great significance for proper dentinogenesis... 
Bmpr2 | Odontoblast | Differentiation | miR-3065-5p | CELLS | BIOPHYSICS | TOOTH DEVELOPMENT | BMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | TARGETING RUNX2 | Bone morphogenetic proteins | Index Medicus
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 2014, Volume 50, Issue 6, pp. 1118 - 1128
Occlusive vasculopathy with intimal hyperplasia and plexogenic arteriopathy are severe histopathological changes characteristic of pulmonary arterial... 
Endothelial dysfunction | Oxidative stress | Vasculopathy | Pulmonary hypertension | Metaanalysis | GAMMA | APOPTOSIS | metaanalysis | CANCER CELLS | pulmonary hypertension | BIOCHEMISTRY & MOLECULAR BIOLOGY | BRCA1 | BETA-CATENIN | endothelial dysfunction | CELL BIOLOGY | DAMAGE RESPONSE | RESPIRATORY SYSTEM | ENDOTHELIAL-CELLS | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | vasculopathy | oxidative stress | CELLULAR-RESPONSE | Chromatin - metabolism | Humans | Cercopithecus aethiops | Pulmonary Artery - metabolism | BRCA1 Protein - metabolism | Lung - metabolism | Gene Expression | Genetic Predisposition to Disease | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Endothelial Cells - metabolism | Down-Regulation | Cells, Cultured | Rats | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | BRCA1 Protein - genetics | Animals | Endothelium, Vascular - metabolism | DNA Repair | DNA Damage | COS Cells | Chromatin - genetics | Hypertension | Cell culture | Transcription factors | Pathogenesis | DNA damage | Genomics | Homeostasis | Gene expression | DNA repair | Endothelium | Proteins | Studies | Rodents | Ligands | Mutation | Bioinformatics | Binding sites | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article