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2006, 2nd ed., ISBN 0199212937, x, 352
Amyotrophic lateral sclerosis (or motor neurone disease) is a rare disease but one that can cause profound suffering for both the patient and their family... 
Amyotrophic lateral sclerosis | Palliative Care | Palliative treatment | therapy | palliative medicine | neurology team | als | psychosocial care | amyotrophic lateral sclerosis | palliative care | motor neurone disease
Book
Journal of the Neurological Sciences, ISSN 0022-510X, 2012, Volume 323, Issue 1-2, pp. 16 - 24
Abstract It is known that the olfactory dysfunction is involved in various neurological diseases, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, Huntington's disease and motor neuron disease... 
Neurology | Multiple sclerosis | Parkinson's disease | Olfactory dysfunction | Motor neuron disease | Functional magnetic resonance imaging | Huntington's disease | Olfactory event-related potentials | Alzheimer's disease | ALZHEIMERS-DISEASE | ENSHEATHING CELLS | PIRIFORM CORTEX | MOTOR-NEURON DISEASE | TIME-COURSE | REGIONAL BRAIN RESPONSES | NEUROSCIENCES | CLINICAL NEUROLOGY | MULTIPLE-SCLEROSIS | ODOR IDENTIFICATION | OF-PENNSYLVANIA SMELL | PARKINSONS-DISEASE | Parkinson Disease - complications | Alzheimer Disease - physiopathology | Alzheimer Disease - complications | Motor Neuron Disease - complications | Sensory Thresholds | Humans | Evoked Potentials | Olfaction Disorders - diagnosis | Parkinson Disease - physiopathology | Neurodegenerative Diseases - complications | Odorants | Huntington Disease - complications | Multiple Sclerosis - complications | Neuropsychological Tests | Olfactory Pathways - physiopathology | Magnetic Resonance Imaging | Multiple Sclerosis - physiopathology | Neurodegenerative Diseases - physiopathology | Aging - physiology | Discrimination (Psychology) | Olfaction Disorders - physiopathology | Motor Neuron Disease - physiopathology | Olfaction Disorders - etiology | Huntington Disease - physiopathology | Nervous system diseases | Diagnostic imaging | Huntington's chorea
Journal Article
Annual review of neuroscience, ISSN 1545-4126, 2008, Volume 31, Issue 1, pp. 151 - 173
Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS... 
Amyotrophic lateral sclerosis | Parkinson's disease | Huntington's disease | Alzheimer's disease | Charcot-Marie-tooth disease | Motor neuron disease | motor neuron disease | MARIE-TOOTH-DISEASE | ACTIVATED PROTEIN-KINASE | HEREDITARY SPASTIC PARAPLEGIA | GLYCOGEN-SYNTHASE KINASE-3 | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | MUTANT SUPEROXIDE-DISMUTASE | amyotrophic lateral sclerosis | HUNTINGTIN-ASSOCIATED PROTEIN-1 | NEUROSCIENCES | Charcot-Marie-Tooth disease | NUCLEOTIDE EXCHANGE FACTOR | CYCLIN-DEPENDENT KINASE-5 | Axonal Transport - genetics | Central Nervous System - metabolism | Humans | Central Nervous System - pathology | Charcot-Marie-Tooth Disease - genetics | Motor Neuron Disease - metabolism | Motor Neuron Disease - genetics | Parkinson Disease - metabolism | Motor Neuron Disease - physiopathology | Charcot-Marie-Tooth Disease - metabolism | Huntington Disease - physiopathology | Alzheimer Disease - physiopathology | Axons - metabolism | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Parkinson Disease - physiopathology | Huntington Disease - metabolism | Animals | Neurodegenerative Diseases - physiopathology | Axons - pathology | Alzheimer Disease - metabolism | Huntington Disease - genetics | Central Nervous System - physiopathology | Charcot-Marie-Tooth Disease - physiopathology | Alzheimer Disease - genetics | Nervous system | Degeneration | Axonal transport | Analysis
Journal Article
2015, Contemporary neurology series, ISBN 019978311X, Volume 88, xxviii, 336
Book
CNS and Neurological Disorders - Drug Targets, ISSN 1871-5273, 2010, Volume 9, Issue 4, pp. 504 - 523
Human neurodegenerative diseases are devastating illnesses that predominantly affect elderly people... 
Bone morphogenetic protein | Parkinson's disease | Neurodegeneration | Drosophila | Motor neuron disease | C-jun n-terminal kinase | Alzheimer's disease | Trinucleotide repeat expansion disease | c-Jun N-terminal kinase | motor neuron disease | trinucleotide repeat expansion disease | X-RELATED GENE | HEREDITARY SPASTIC PARAPLEGIA | DOPAMINERGIC NEURON DEGENERATION | TAU-INDUCED NEURODEGENERATION | ALZHEIMERS-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | ALPHA-SYNUCLEIN | FRONTOTEMPORAL LOBAR DEGENERATION | bone morphogenetic protein | NEUROSCIENCES | SPINAL MUSCULAR-ATROPHY | PAIRED HELICAL FILAMENTS | PHARMACOLOGY & PHARMACY | Drosophila melanogaster - physiology | Fragile X Syndrome - physiopathology | Humans | Paraplegia - genetics | Trinucleotide Repeat Expansion - physiology | Drosophila melanogaster - genetics | Alzheimer Disease - pathology | Friedreich Ataxia - genetics | Friedreich Ataxia - physiopathology | Mitochondria - genetics | Motor Neuron Disease - genetics | Paraplegia - physiopathology | Motor Neuron Disease - physiopathology | Disease Models, Animal | Fragile X Syndrome - genetics | Alzheimer Disease - physiopathology | Parkinson Disease - pathology | Neurodegenerative Diseases - pathology | Neurodegenerative Diseases - genetics | Parkinson Disease - genetics | Parkinson Disease - physiopathology | Animals | Neurodegenerative Diseases - physiopathology | Trinucleotide Repeat Expansion - genetics | Alzheimer Disease - genetics | Mitochondria - physiology
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2011, Volume 15, Issue 10, pp. 2025 - 2039
... •  The UPR and neurodegenerative disease ‐  Alzheimer's disease ‐  Parkinson's disease ‐  Amyotrophic lateral sclerosis ‐  Prion diseases... 
prions disease | autophagy | Alzheimer’s disease | UPR | neurodegeneration | ER stress | apoptosis | amyotrophic lateral sclerosis | Parkinson’s disease | Parkinson's disease | Neurodegeneration | Amyotrophic lateral sclerosis | Prions disease | Alzheimer's disease | Autophagy | Apoptosis | INDUCED CELL-DEATH | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | UBIQUITIN-PROTEASOME SYSTEM | ALZHEIMERS-DISEASE | AMYOTROPHIC-LATERAL-SCLEROSIS | MOTOR-NEURON DISEASE | ALPHA-SYNUCLEIN | CELL BIOLOGY | PRION PROTEIN | PARKINSONS-DISEASE | Endoribonucleases - genetics | Prion Diseases - genetics | eIF-2 Kinase - metabolism | Humans | Activating Transcription Factor 6 - genetics | Membrane Proteins - metabolism | Parkinson Disease - metabolism | Autophagy - genetics | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Endoribonucleases - metabolism | Membrane Proteins - genetics | Amyotrophic Lateral Sclerosis - genetics | Protein-Serine-Threonine Kinases - genetics | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Unfolded Protein Response | Activating Transcription Factor 6 - metabolism | Endoplasmic Reticulum Stress | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Alzheimer Disease - genetics | Prion Diseases - metabolism | Cytochrome | Oxidative stress | Transcription factors | Disease | Disorders | mRNA | Biomass | Kinases | Proteins | Mitochondria | Protein folding | Proteolysis | Attenuation | Tumor necrosis factor-TNF | Movement disorders | Cellular manufacture | Free radicals | Splicing | Neurodegenerative diseases | Environmental factors | Inflammation | Calcium (mitochondrial) | Pathology | Renewable energy | Cell death | Excitotoxicity | Quality control | Mutation | Disruption | Endoplasmic reticulum | Phagocytosis | Calcium ions | Cellular stress response | Reviews
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2017, Volume 93, Issue 5, pp. 1015 - 1034
.... Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating the normal functions of autophagy... 
motor neuron disease | autophagy | Alzheimer’s disease | neurodegeneration | dementia | tau | Huntington’s disease | lysosome | Parkinson’s disease | Parkinson's disease | Huntington's disease | Alzheimer's disease | NEURAL STEM-CELLS | PARKIN-DEFICIENT MICE | HEREDITARY SPASTIC PARAPARESIS | MACHADO-JOSEPH-DISEASE | TAUOPATHY IN-VITRO | AGGREGATE-PRONE PROTEINS | NUCLEOTIDE EXCHANGE FACTOR | AMYOTROPHIC-LATERAL-SCLEROSIS | LYSOSOMAL STORAGE DISORDERS | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | Animals | Lysosomes - metabolism | Neurodegenerative Diseases - pathology | Proteins - metabolism | Humans | Neurodegenerative Diseases - therapy | Signal Transduction - physiology | Autophagy - physiology | Neurodegenerative Diseases - metabolism | Motor Neurons - pathology | Nervous system diseases | Cell differentiation | Health aspects | Stem cells | Medical genetics | Medical research | Neurons | Medicine, Experimental | Drug discovery | Brain | Cargo | Phosphorylation | Regulators | Energy levels | Amino acid starvation | Homeostasis | Amino acids | Chains | Homology | AKT protein | Activation | Kinases | Autophagy | Neurogenesis | Lipid bilayers | Defects | Proteins | Allosteric properties | Neurodegeneration | Rodents | Nutrients | Aspartic acid | Degeneration | Growth factors | Assembly | Elongation | Enzymes | Pathogens | Berberine | Starvation | AMP | BRCA1 protein | Amyotrophic lateral sclerosis | Longevity | Survival | Adhesion | 1-Phosphatidylinositol 3-kinase | Peroxisomes | Phototransduction | Aggregates | Protein kinase | Cell death | β-Amyloid | Aberration | Apoptosis
Journal Article
Nature neuroscience, ISSN 1546-1726, 2009, Volume 12, Issue 5, pp. 627 - 636
The mechanisms underlying disease manifestations in neurodegeneration remain unclear, but their understanding is critical to devising effective therapies... 
NEURODEGENERATIVE DISEASE | UNFOLDED PROTEIN RESPONSE | MOTOR-NEURON DEGENERATION | WILD-TYPE SOD1 | ALS-LINKED SOD1 | MOUSE MODEL | AMYOTROPHIC-LATERAL-SCLEROSIS | ENDOPLASMIC-RETICULUM STRESS | MUTANT SUPEROXIDE-DISMUTASE | NEUROSCIENCES | TRANSGENIC MICE | Microglia - metabolism | Central Nervous System - metabolism | Amyotrophic Lateral Sclerosis - physiopathology | Ubiquitin - metabolism | Central Nervous System - pathology | Endoplasmic Reticulum - metabolism | Gliosis - physiopathology | Thiourea - pharmacology | Mice, Neurologic Mutants | Motor Neurons - classification | Motor Neurons - pathology | Ubiquitination | Neuroprotective Agents - pharmacology | Disease Models, Animal | Wallerian Degeneration - genetics | Biomarkers - metabolism | Genetic Predisposition to Disease - genetics | Gliosis - genetics | Endoplasmic Reticulum - genetics | Wallerian Degeneration - metabolism | Amyotrophic Lateral Sclerosis - genetics | Gliosis - metabolism | Wallerian Degeneration - physiopathology | Biomarkers - analysis | Oxidative Stress - genetics | Cinnamates - pharmacology | Disease Progression | Protein Folding | Motor Neurons - metabolism | Phenotype | Animals | Amyotrophic Lateral Sclerosis - metabolism | Mice | Central Nervous System - physiopathology | Thiourea - analogs & derivatives | Motor neurons | Physiological aspects | Amyotrophic lateral sclerosis | Nervous system | Degeneration | Research | Endoplasmic reticulum
Journal Article