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Nature (London), ISSN 1476-4687, 2019, Volume 570, Issue 7759, pp. 77 - 82
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 550, Issue 7674, pp. 67 - 73
.... Here we use CRISPR-Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 during human embryogenesis... 
ANALYZER | HUMAN EMBRYOS | INNER CELL MASS | FGF | MULTIDISCIPLINARY SCIENCES | GENES | HUMAN ZYGOTES | GENERATION | CAS9 | NORMALIZATION | POU DOMAIN | Human Embryonic Stem Cells - cytology | Humans | Zygote - metabolism | Substrate Specificity | Male | Embryo, Mammalian - metabolism | Octamer Transcription Factor-3 - genetics | Ectoderm - metabolism | Gene Expression Regulation, Developmental | Female | Nanog Homeobox Protein - genetics | Human Embryonic Stem Cells - metabolism | Germ Layers - metabolism | Blastocyst - metabolism | Embryonic Development - genetics | CRISPR-Cas Systems - genetics | Gene Editing | Cell Lineage | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Octamer Transcription Factor-3 - metabolism | Mice | Octamer Transcription Factor-3 - deficiency | Nanog Homeobox Protein - metabolism | Embryonic development | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Genes | Oct-4 protein | Embryo cells | Genomes | CDX2 protein | Kinases | Trophectoderm | Proteins | Embryogenesis | Embryology | Cell fate | Null cells | Deoxyribonucleic acid--DNA | CRISPR | Gene expression | Ribonucleic acid--RNA | Embryos | Embryonic growth stage | Studies | Zygotes | Molecular modelling | Microinjection | Stem cells | Protein expression | Genetic engineering | Mutation | Pluripotency
Journal Article
Development (Cambridge), ISSN 0950-1991, 01/2017, Volume 144, Issue 2, pp. 175 - 186
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 557, Issue 7703, pp. 112 - 117
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors,... 
LINEAR UBIQUITIN CHAINS | PSEUDOKINASE MLKL | KEY REGULATOR | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RIPK1 | MICE | ASSEMBLY COMPLEX | DEFICIENCY | IMMUNODEFICIENCY | AUTOINFLAMMATION | Protein Kinases - genetics | Signal Transduction | Mice, Inbred C57BL | Caspase 8 - metabolism | Embryonic Development - genetics | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Hematopoiesis - genetics | Receptors, Tumor Necrosis Factor, Type I - metabolism | Caspase 8 - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Death - genetics | Endothelial Cells - cytology | Protein Domains | Ubiquitin-Protein Ligases - deficiency | Carrier Proteins - chemistry | Female | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Embryo Loss - genetics | Ubiquitin-Protein Ligases - genetics | Prevention | Ubiquitin | Physiological aspects | Cell death | Hematopoiesis | Health aspects | Tumor necrosis factor receptors | Deregulation | Disease | Activation | Lethality | Gestation | Kinases | Defects | Recruitment | Receptors | Embryogenesis | Cell activation | Clonal deletion | Tumor necrosis factor-TNF | Trends | Assembly | Phenotypes | Fetuses | Mortality | Caspase | Inflammation | Embryos | Endothelial cells | Embryonic growth stage | Caspase-8 | Mutation | Autoimmune diseases | Apoptosis | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 2014, Volume 27, pp. 60 - 66
... 0959-437X/© 2014 Elsevier Ltd. All rights reserved. Introduction During embryogenesis, the biosynthesis and degradation of molecules is essential for reorganizing... 
Medical Education | YEAST | COMPLEX | VISCERAL ENDODERM | ENDOCYTIC PATHWAY | MOUSE EMBRYOS | GENETICS & HEREDITY | DEGRADATION | MICE | MICROAUTOPHAGY | SACCHAROMYCES-CEREVISIAE | PATERNAL MITOCHONDRIAL-DNA | CELL BIOLOGY | Animals | Embryonic Development | Gene Expression Regulation, Developmental | Autophagy | Humans | Embryonic development
Journal Article
Nature, ISSN 0028-0836, 02/2000, Volume 403, Issue 6769, pp. 501 - 502
... to establish parent-specific developmental programmes during early embryogenesis. 
PREIMPLANTATION DEVELOPMENT | METHYLATION | MULTIDISCIPLINARY SCIENCES | MOUSE EMBRYOS | DNA-REPLICATION
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 356, Issue 6334, pp. eaal1810 - eaal1810
Journal Article