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AMERICAN JOURNAL OF PATHOLOGY, ISSN 0002-9440, 02/2014, Volume 184, Issue 2, pp. 322 - 331
Polyploidy (alias whole genome amplification) refers to organisms containing more than two basic sets of chromosomes. Polyploidy was first observed in plants... 
RAT-LIVER | PARTIAL-HEPATECTOMY | HEPATOCYTE POPULATIONS | GENE-EXPRESSION | POLYPLOIDY | DNA-SYNTHESIS | PATHOLOGY | CELL-CYCLE PROGRESSION | MOUSE HEPATOCYTES | PLOIDY | MYELOMONOCYTIC CELLS
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, p. 13369
Hepatocytes are functionally heterogeneous and are divided into two distinct populations based on their metabolic zonation: the periportal and pericentral... 
MATURE HEPATOCYTES | CELLS | HOMEOSTASIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | ZONATION | GENE-EXPRESSION | OCCURS | MOUSE HEPATOCYTES
Journal Article
Toxicology Research, ISSN 2045-452X, 2013, Volume 2, Issue 1, pp. 23 - 39
Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and... 
LONG-TERM CULTURE | RAT HEPATOCYTES | SINUSOIDAL ENDOTHELIAL-CELLS | ADULT-MOUSE HEPATOCYTES | NITRIC-OXIDE SYNTHASE | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | TOXICOLOGY | MULTIWELL PLATE CULTURE | HEPATOCYTE-LIKE CELLS | DRUG-METABOLISM
Journal Article
Journal of Hepatology, ISSN 0168-8278, 07/2018, Volume 69, Issue 1, pp. 51 - 59
Acetaminophen (APAP) induced hepatotoxicity is a leading cause of acute liver failure worldwide. It is well established that the liver damage induced by... 
Gut microbiota | Metabolomics | Acute liver injury | Acetaminophen | SIGNAL-TRANSDUCTION PATHWAYS | TRANSLOCATION | INTESTINAL MICROBIOTA | N-TERMINAL KINASE | SUSCEPTIBILITY | ATHEROSCLEROSIS | MOUSE HEPATOCYTES | NECROSIS | METABOLISM | GASTROENTEROLOGY & HEPATOLOGY | INDUCED HEPATOTOXICITY | acetaminophen | metabolomics | gut microbiota | acute liver injury
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 469 - 13
Three-dimensional cell culture is emerging as a more relevant alternative to the traditional two-dimensional format. Yet the ability to perform cytometry at... 
TUMOR SPHEROIDS | IN-VITRO | LIVER-CELLS | METABOLISM | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE SPHEROIDS | ENDOTHELIAL-CELLS | DROPLET MICROFLUIDICS | MULTICELLULAR SPHEROIDS | E-CADHERIN | MOUSE HEPATOCYTES | Cytometry | Cell culture | Cultures | Two dimensional analysis | Microfluidics | Spheroids
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 2, pp. 642 - 659.e46
Background & Aims The profibrogenic role of transforming growth factor (TGF)-β in liver has mostly been attributed to hepatic stellate cell activation and... 
Gastroenterology and Hepatology | EPITHELIAL-MESENCHYMAL TRANSITION | FIBROSIS | GROWTH-FACTOR-BETA | IN-VITRO | DIRECT BINDING | HEPATIC STELLATE CELLS | DEPENDENT EXPRESSION | TRANSFORMING GROWTH-FACTOR-BETA-1 | MOUSE HEPATOCYTES | GASTROENTEROLOGY & HEPATOLOGY | TRANSDIFFERENTIATION
Journal Article
Journal Article
Toxicology research, ISSN 2045-452X, 01/2013, Volume 2, Issue 1, pp. 23 - 39
Over the years, various liver-derived model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver... 
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 01/2012, Volume 417, Issue 3, pp. 1100 - 1105
Epithelial-to-mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. Snail1 is a well-known... 
BREAST-CARCINOMA | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER FIBROSIS | TRANSCRIPTION FACTOR SNAIL | TUMOR-CELLS | MOUSE HEPATOCYTES | E-cadherin | REPRESSORS ZEB1 | CANCER | BIOPHYSICS | Hepatocyte | Snail1 | miR-30 | Epithelial-to-mesenchymal transition (EMT) | EXPRESSION | PROGRESSION
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2013, Volume 30, Issue 9, pp. 2174 - 2187
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular... 
Biochemistry, general | Biomedical Engineering | drug transporters | nuclear receptors | acetaminophen | Biomedicine | Pharmacy | hepatotoxicity | drug metabolism | Medical Law | Pharmacology/Toxicology | ACUTE LIVER-FAILURE | PREGNANE-X RECEPTOR | APOPTOSIS-INDUCING FACTOR | COVALENT BINDING | MITOCHONDRIAL OXIDANT STRESS | CHEMISTRY, MULTIDISCIPLINARY | S-TRANSFERASE-PI | INDUCED HEPATIC-NECROSIS | CULTURED MOUSE HEPATOCYTES | BILIARY-EXCRETION | PHARMACOLOGY & PHARMACY | GLUTATHIONE DEPLETION | Acetaminophen - metabolism | Analgesics, Non-Narcotic - blood | Analgesics, Non-Narcotic - pharmacokinetics | Acetaminophen - toxicity | Humans | Liver - metabolism | Antipyretics - toxicity | Cytochrome P-450 Enzyme System - metabolism | Glutathione Transferase - metabolism | Analgesics, Non-Narcotic - metabolism | Chemical and Drug Induced Liver Injury - diagnosis | Acetaminophen - blood | Animals | Antipyretics - pharmacokinetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Protein Binding | Acetaminophen - pharmacokinetics | Antipyretics - blood | Antipyretics - metabolism | Cellular proteins | Metabolites | Acetaminophen | Transferases | Cytochrome P-450 | Physiological aspects | Sulfates | Protein binding | Metabolism | Medical diagnosis | Hepatology | Index Medicus
Journal Article