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Journal of Nutrition, ISSN 0022-3166, 04/2011, Volume 141, Issue 4, pp. 603 - 610
Emerging evidence suggests that the lack of PPAR alpha enhances hepatic steatosis and inflammation in Ppara-null mice when fed a high-fat diet (HFD). Thus, the... 
OXIDATIVE STRESS | NUTRITION & DIETETICS | DIET | DISEASE | CHOLINE-DEFICIENT | HEPATOMA-CELLS | MOUSE-LIVER | STEATOHEPATITIS | KAPPA-B | MODEL | KINASE ACTIVATION
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 3, pp. 286 - 297
The NF-κB activating kinase IKKβ suppresses early chemically induced liver tumorigenesis by inhibiting hepatocyte death and compensatory proliferation. To... 
LIVER-CANCER | HEPATOCELLULAR-CARCINOMA | STEM-CELLS | ONCOLOGY | INFLAMMATION | CHEMICAL HEPATOCARCINOGENESIS | COMPENSATORY PROLIFERATION | MOUSE-LIVER | COLITIS-ASSOCIATED CANCER | HEPATITIS-C | TUMORIGENESIS | CELL BIOLOGY
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2017, Volume 127, pp. 986 - 996
A doR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been... 
Mouse liver microsomes | Adenosine receptors | Xanthine | Pharmacokinetics | 2-Oxopyrrolidine
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 986 - 996
A doR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been... 
Mouse liver microsomes | Adenosine receptors | Xanthine | Pharmacokinetics | 2-Oxopyrrolidine | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 09/2014, Volume 15, Issue 3, pp. 340 - 349
Journal Article
Nature Biotechnology, ISSN 1087-0156, 03/2016, Volume 34, Issue 3, pp. 334 - 338
Many genetic liver diseases in newborns cause repeated, often lethal, metabolic crises. Gene therapy using nonintegrating viruses such as adeno-associated... 
WILD-TYPE | HEPATIC GENE-TRANSFER | TOLERANCE INDUCTION | ADENOASSOCIATED VIRUS | RHESUS-MONKEYS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN ORNITHINE TRANSCARBAMYLASE | MOUSE-LIVER | CRISPR-CAS9 | GENOME | DELIVERY | Physiological aspects | Liver diseases | Dependoviruses | Host-virus relationships | Observations | Health aspects | Gene therapy | DNA repair | Rodents | Genomics | Index Medicus
Journal Article
The American Journal of Pathology, ISSN 0002-9440, 09/2018, Volume 188, Issue 9, pp. 2059 - 2073
Peribiliary glands (PBGs) are accessory glands with mucinous and serous acini in the biliary tree. The PBG is composed of a heterogeneous cell population, such... 
CHOLANGIOCYTES | STEM-CELLS | EPITHELIUM | REGENERATION | HUMANS | STEM/PROGENITOR CELLS | MOUSE-LIVER | TREE | FUNCTIONAL-CHARACTERIZATION | PATHOLOGY | IDENTIFICATION
Journal Article
CELL, ISSN 0092-8674, 09/2006, Volume 126, Issue 5, pp. 941 - 954
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals have seven Sir2 homologs (SIRT1-7). We show... 
LIFE-SPAN EXTENSION | TRANSCRIPTION FACTORS | ENZYME-ACTIVITIES | STIMULATED INSULIN-SECRETION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN SIR2 | ADP-RIBOSYLATION | PROTEIN DEACETYLASES | MOUSE-LIVER | SACCHAROMYCES-CEREVISIAE | DEPENDENT DEACETYLASE | CELL BIOLOGY
Journal Article
by Ritawidya and Ludwig and Briel and Brust and Scheunemann
Molecules, ISSN 1420-3049, 07/2019, Volume 24, Issue 15, p. 2791
Phosphodiesterase 2A (PDE2A) is highly expressed in distinct areas of the brain, which are known to be related to neuropsychiatric diseases. The development of... 
Index Medicus | fluorinated | Mouse Liver Microsomes (MLM) | Benzoimidazotriazine (BIT) | Phosphodiesterase 2A (PDE2A) | Positron Emission Tomography (PET)
Journal Article
HEPATOLOGY, ISSN 0270-9139, 06/2014, Volume 59, Issue 6, pp. 2344 - 2357
beta-catenin signaling can be both a physiological and oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing the liver to... 
BILE-ACID | CYTOCHROME-P450 EXPRESSION | ZONATION | TRANSCRIPTION | GENE-EXPRESSION | CHOLESTASIS | MOUSE-LIVER | BETA-CATENIN | HEPATOCELLULAR CARCINOMAS | KNOCKOUT MICE | GASTROENTEROLOGY & HEPATOLOGY
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 121, Issue 7, pp. 977 - 990
IκB kinase β (IKKβ), required for NF-κB activation, links chronic inflammation with carcinogenesis. We investigated whether IKKβ is involved in chemically... 
JNK ACTIVATION | TUMOR-NECROSIS-FACTOR | HEPATOCELLULAR-CARCINOMA | NUCLEAR-FACTOR | LIVER-REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE-LIVER | TNF-ALPHA | NF-KAPPA-B | TRANSGENIC MICE | CELL-DEATH | CELL BIOLOGY
Journal Article