X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
mps1 (186) 186
index medicus (185) 185
cell biology (144) 144
humans (139) 139
mitosis (132) 132
protein-serine-threonine kinases - metabolism (107) 107
cell cycle proteins - metabolism (103) 103
mitotic checkpoint (100) 100
phosphorylation (99) 99
biochemistry & molecular biology (86) 86
spindle assembly checkpoint (85) 85
animals (79) 79
protein-serine-threonine kinases - genetics (68) 68
cell cycle proteins - genetics (61) 61
kinetochores - metabolism (59) 59
protein-tyrosine kinases - metabolism (57) 57
cell cycle (55) 55
kinetochore (51) 51
hela cells (48) 48
kinetochores (47) 47
article (46) 46
kinase (46) 46
chromosome segregation (45) 45
proteins (44) 44
spindle apparatus - metabolism (44) 44
mps1 kinase (43) 43
protein-kinase (43) 43
chromosomes (41) 41
budding yeast (39) 39
cancer (39) 39
cell line, tumor (39) 39
protein-tyrosine kinases - genetics (39) 39
anaphase (37) 37
assembly checkpoint (36) 36
kinases (36) 36
protein (35) 35
spindle checkpoint (35) 35
aneuploidy (34) 34
centrosome duplication (34) 34
nuclear proteins - metabolism (33) 33
oncology (33) 33
multidisciplinary sciences (32) 32
saccharomyces-cerevisiae (32) 32
expression (31) 31
protein-serine-threonine kinases - antagonists & inhibitors (31) 31
pole body duplication (30) 30
signal transduction (29) 29
activation (28) 28
cell cycle proteins - antagonists & inhibitors (28) 28
chromosomal instability (28) 28
localization (28) 28
recruitment (28) 28
binding (27) 27
biology (27) 27
molecular sequence data (27) 27
protein binding (27) 27
protein kinases - metabolism (27) 27
research (27) 27
spindle-assembly checkpoint (27) 27
cells (26) 26
mutation (26) 26
amino acid sequence (25) 25
aurora-b (25) 25
small-molecule inhibitor (25) 25
ttk (25) 25
cenp-e (24) 24
checkpoint (24) 24
female (24) 24
protein-tyrosine kinases (24) 24
protein-tyrosine kinases - antagonists & inhibitors (24) 24
bubr1 (23) 23
cell-cycle (23) 23
inhibition (23) 23
cell division (22) 22
duplication gene mps1 (22) 22
kinetochore localization (22) 22
m phase cell cycle checkpoints (22) 22
mice (22) 22
mitosis - physiology (22) 22
anaphase-promoting complex (21) 21
gene mps1 (21) 21
genetics & heredity (21) 21
microtubules (21) 21
microtubules - metabolism (21) 21
spindle apparatus - genetics (21) 21
bub1 (20) 20
complex (20) 20
mad2 (20) 20
protein kinases (20) 20
physiological aspects (19) 19
spindle (19) 19
cell line (18) 18
centrosome (18) 18
gene expression (18) 18
protein kinase inhibitors - pharmacology (18) 18
spindle apparatus - physiology (18) 18
cdc20 (17) 17
genetic aspects (17) 17
human mps1 kinase (17) 17
mitotic spindle (17) 17
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4401 - 4410
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we... 
CFI-402257 | POTENT | CHEMISTRY, MEDICINAL | CHECKPOINT | MPS1 | DISCOVERY
Journal Article
Genetics, ISSN 0016-6731, 01/2015, Volume 200, Issue 1, pp. 79 - 90
Journal Article
by Liu, J and Cheng, X and Zhang, Y and Li, S and Cui, H and Zhang, L and Shi, R and Zhao, Z and He, C and Wang, C and Zhao, H and Zhang, C and Fisk, H.A and Guadagno, T.M and Cui, Y
Oncogene, ISSN 0950-9232, 02/2013, Volume 32, Issue 6, pp. 713 - 723
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2009, Volume 28, Issue 8, pp. 1099 - 1110
The protein kinase Mps1 is, among others, essential for the spindle assembly checkpoint (SAC). We found that Saccharomyces cerevisiae Mps1 interacts physically... 
kinetochore | centromere | Mps1 | spindle assembly checkpoint | Ndc80 | Kinetochore | Centromere | Spindle assembly checkpoint | BI-ORIENTATION | COMPLEX | BUDDING YEAST | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLE BODY DUPLICATION | TENSION | CELL BIOLOGY | MPS1 KINASE | GENE MPS1 | MITOTIC CHECKPOINT | KINETOCHORE-MICROTUBULE ATTACHMENT | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Microtubules - metabolism | Protein-Tyrosine Kinases - genetics | Spindle Apparatus - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Kinetochores - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Alanine - metabolism | Nuclear Proteins - metabolism | Aurora Kinases | Saccharomyces cerevisiae Proteins - genetics | Animals | Saccharomyces cerevisiae Proteins - metabolism | Cell Cycle - physiology | Recombinant Fusion Proteins - genetics | Aspartic Acid - metabolism | Signal Transduction - physiology | Genes, cdc | Signal transduction | Biochemistry | Kinases | Molecular biology | Cell cycle
Journal Article
Genetics, ISSN 0016-6731, 05/2015, Volume 200, Issue 1, pp. 79 - 90
Kinetochores are conserved protein complexes that bind the replicated chromosomes to the mitotic spindle and then direct their segregation. To better... 
kinetochore | centromere | Mps1 | Investigations | Cnn1 | CENP-T
Journal Article
Annals of Oncology, ISSN 0923-7534, 10/2015, Volume 26, Issue 10, pp. 2180 - 2192
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. 3127 - 3132
Loss of cell-cycle control is a hallmark of human cancer. Cell-cycle checkpoints are essential for maintaining genome integrity and balanced growth and... 
CFI-402257 | Inhibitor | Mps1/TTK | Cancer | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | SIGNATURE | DISCOVERY | CHROMOSOMAL INSTABILITY | MITOSIS | ANEUPLOIDY | inhibitor | NMS-P715 | cancer | MITOTIC CHECKPOINT | EXPRESSION | Neoplasms - metabolism | RNA, Small Interfering - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Protein-Tyrosine Kinases - genetics | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Pyrazoles - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Pyrazoles - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Pyrimidines - administration & dosage | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Pyrimidines - pharmacology | Tumor Burden | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | Cell Line, Tumor | Pyrimidines - pharmacokinetics | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Phosphotransferases | Health aspects | Methods | Biological Sciences | TTK | Mps1
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2019, Volume 175, pp. 247 - 268
As a dual-specificity protein kinase, monopolar spindle 1 (Mps1) is one of the main kinases involved in kinetochore localization and the spindle assembly... 
Drug design | Structure−activity relationship | Mps1/TTK inhibitors | Cancer | Chemotherapy | Chromosomes | Protein kinases
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2019, Volume 593, Issue 20, pp. 2889 - 2907
In mitosis, the spindle assembly checkpoint (SAC) monitors the formation of microtubule‐kinetochore attachments during capture of chromosomes by the mitotic... 
kinase | chromosome segregation | MPS1 | spindle assembly checkpoint | CDK1 | cyclin B1 | kinetochore | phosphatase | PP2A‐B55 | mitosis
Journal Article
Experimental Cell Research, ISSN 0014-4827, 12/2019, Volume 385, Issue 1, p. 111669
The main objective of our study was to explore changes in the expression levels of differentially expressed genes associated with prostate cancer progression... 
Gleason score | TTK/Mps1 | Prostate cancer | Cell cycle | ONCOLOGY | KINASE TTK | SPINDLE ASSEMBLY CHECKPOINT | CELL-CYCLE | CELL BIOLOGY
Journal Article
British Journal of Cancer, ISSN 0007-0920, 04/2017, Volume 116, Issue 9, pp. 1166 - 1176
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 10/2019, Volume 18, Issue 10, pp. 1775 - 1786
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is... 
MPS1 KINASE | MITOSIS | CFI-402257 | SIGNALING PATHWAYS | ONCOLOGY | CENTROSOME AMPLIFICATION | PROTEIN-KINASE | SPINDLE ASSEMBLY CHECKPOINT | CELL-CYCLE | DUPLICATION | DISCOVERY
Journal Article
Science, ISSN 0036-8075, 06/2015, Volume 348, Issue 6240, pp. 1260 - 1264
The spindle checkpoint of the cell division cycle senses kinetochores that are not attached to microtubules and prevents precocious onset of anaphase, which... 
LOCALIZATION | RECRUITMENT | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | SPINDLE ASSEMBLY CHECKPOINT | HEC1 | KINASE MPS1 | BUB1 | AURORA-B | REVEALS | Proteins | Cell division | Microbiology | Molecular biology | Kinases | Binding | Attachment | Spindles | Chromosomes | Recruitment
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 28, pp. 19525 - 19542
Accurate chromosome segregation is dependent on the spindle assembly checkpoint (SAC). In current models, the key direct role of Aurora B in the SAC has been... 
Inhibition | SAC | Mitosis | MPS1 | Aurora B
Journal Article